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    Grik3 glutamate receptor, ionotropic, kainate 3 [ Mus musculus (house mouse) ]

    Gene ID: 14807, updated on 12-May-2024

    Summary

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    Official Symbol
    Grik3provided by MGI
    Official Full Name
    glutamate receptor, ionotropic, kainate 3provided by MGI
    Primary source
    MGI:MGI:95816
    See related
    Ensembl:ENSMUSG00000001985 AllianceGenome:MGI:95816
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GluK3; Glur7; Glur-7; GluR7-3; 9630027E11
    Summary
    Glutamate receptors are the predominant excitatory neurotransmitter receptors in the mammalian brain and are activated in a variety of normal neurophysiologic processes. This gene product belongs to the kainate family of glutamate receptors, which are composed of four subunits and function as ligand-activated ion channels. Transcript variants encoding different isoforms have been described for this gene, however, their full-length nature is not known. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in frontal lobe adult (RPKM 10.1), whole brain E14.5 (RPKM 9.8) and 8 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Grik3 in Genome Data Viewer
    Location:
    4 D2.2; 4 58.91 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (125384025..125607966)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (125490259..125714173)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11366 Neighboring gene predicted gene, 40247 Neighboring gene predicted gene, 32756 Neighboring gene STARR-seq mESC enhancer starr_11372 Neighboring gene microRNA 692-2 Neighboring gene STARR-seq mESC enhancer starr_11375 Neighboring gene ferritin light polypeptide 2, pseudogene Neighboring gene predicted gene, 32807 Neighboring gene STARR-seq mESC enhancer starr_11380 Neighboring gene predicted gene, 54257 Neighboring gene STARR-seq mESC enhancer starr_11383 Neighboring gene predicted gene, 40249 Neighboring gene RIKEN cDNA 2610028E06 gene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking. Huyghe D, et al. J Neurosci, 2011 Aug 10. PMID 21832194, Free PMC Article
    2. Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3. Pigoni M, et al. EMBO J, 2020 Aug 3. PMID 32567721, Free PMC Article
    3. The kainate receptor antagonist UBP310 but not single deletion of GluK1, GluK2, or GluK3 subunits, inhibits MPTP-induced degeneration in the mouse midbrain. Stayte S, et al. Exp Neurol, 2020 Jan. PMID 31513786
    4. Unequal expression of allelic kainate receptor GluR7 mRNAs in human brains. Schiffer HH, et al. J Neurosci, 2000 Dec 15. PMID 11124978, Free PMC Article
    5. Changes in expression of glutamate receptor subunits following photoreceptor degeneration in the rd mouse retina. Duvoisin RM, et al. Neurosci Lett, 1995 Jan 2. PMID 7538211

    See all (55) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
      Title: Behavioral analysis of kainate receptor KO mice and the role of GluK3 subunit in anxiety.
    2. Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
      Title: Seizure protein 6 controls glycosylation and trafficking of kainate receptor subunits GluK2 and GluK3.
    3. loss of FMRP leads to the abnormal function and localization of kainite receptors.
      Title: Reduced synaptic function of Kainate receptors in the insular cortex of Fmr1 Knock-out mice.
    4. Polarized trafficking of spliced variant GluK3b in neurons may be controlled by the regulation of receptor endocytosis.
      Title: Endocytosis of the glutamate receptor subunit GluK3 controls polarized trafficking.
    5. GluR7, a kainate receptor (KAR) subunit with no known function in the brain, is identified as an essential subunit of presynaptic autoreceptors that facilitate hippocampal mossy fiber synaptic transmission.
      Title: GluR7 is an essential subunit of presynaptic kainate autoreceptors at hippocampal mossy fiber synapses.
    6. GluR7 kainate receptor subunit splice variants differentially traffic from the ER to the plasma membrane
      Title: Differential trafficking of GluR7 kainate receptor subunit splice variants.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables adenylate cyclase inhibiting G protein-coupled glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables glutamate-gated receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables kainate selective glutamate receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kainate selective glutamate receptor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ligand-gated monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    enables ligand-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    enables monoatomic ion channel activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables signaling receptor activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables transmitter-gated monoatomic ion channel activity involved in regulation of postsynaptic membrane potential IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in G protein-coupled glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glutamate receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in modulation of chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within monoatomic ion transmembrane transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in monoatomic ion transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of synaptic transmission, glutamatergic ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of membrane potential ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of presynaptic membrane potential IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in synaptic transmission, glutamatergic IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in dendrite cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    part_of kainate selective glutamate receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in perikaryon ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    located_in postsynaptic membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in terminal bouton ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    glutamate receptor ionotropic, kainate 3
    Names
    glutamate receptor 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081097.3 → NP_001074566.1  glutamate receptor ionotropic, kainate 3 precursor

      See identical proteins and their annotated locations for NP_001074566.1

      Status: REVIEWED

      Source sequence(s)
      AL607090, AL627328
      Consensus CDS
      CCDS38878.1
      UniProtKB/Swiss-Prot
      B1AS29, Q17R20, Q9JIA8
      Related
      ENSMUSP00000030676.8, ENSMUST00000030676.8
      Conserved Domains (2) summary
      cd06393
      Location:34 → 417
      PBP1_iGluR_Kainate_GluR5_7; N-terminal leucine/isoleucine/valine-binding protein (LIVBP)-like domain of the GluR5-7 subunits of Kainate receptor
      cd13723
      Location:433 → 801
      PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      125384025..125607966
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006502772.4 → XP_006502835.1  glutamate receptor ionotropic, kainate 3 isoform X1

      Conserved Domains (2) summary
      cd13723
      Location:433 → 801
      PBP2_iGluR_Kainate_GluR7; GluR7 subtype of kainate receptor, type 2 periplasmic-binding fold superfamily
      cd06382
      Location:37 → 417
      PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors

    2. XM_036163688.1 → XP_036019581.1  glutamate receptor ionotropic, kainate 3 isoform X3

      Conserved Domains (2) summary
      cd06382
      Location:37 → 417
      PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
      cl21456
      Location:433 → 697
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily

    3. XM_017319980.3 → XP_017175469.1  glutamate receptor ionotropic, kainate 3 isoform X2

      Conserved Domains (2) summary
      cd06382
      Location:37 → 417
      PBP1_iGluR_Kainate; N-terminal leucine-isoleucine-valine binding protein (LIVBP)-like domain of the kainate receptors
      cl21456
      Location:443 → 733
      Periplasmic_Binding_Protein_Type_2; Type 2 periplasmic binding fold superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1AS29.1 GenPept UniProtKB/Swiss-Prot:B1AS29

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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