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    prom1b prominin 1 b [ Danio rerio (zebrafish) ]

    Gene ID: 378834, updated on 27-Mar-2024

    Summary

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    Official Symbol
    prom1bprovided by ZNC
    Official Full Name
    prominin 1 bprovided by ZNC
    Primary source
    ZFIN:ZDB-GENE-031003-1
    See related
    Ensembl:ENSDARG00000034007 AllianceGenome:ZFIN:ZDB-GENE-031003-1
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    proml2
    Summary
    Predicted to enable cholesterol binding activity. Acts upstream of or within photoreceptor cell outer segment organization. Located in apical plasma membrane. Is expressed in nervous system; otic vesicle; and testis. Human ortholog(s) of this gene implicated in cone-rod dystrophy 12 and retinitis pigmentosa 41. Orthologous to human PROM1 (prominin 1). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See prom1b in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (22712925..22757213, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (22022186..22066472, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene fibroblast growth factor binding protein 2b Neighboring gene zinc finger, MYND-type containing 10 Neighboring gene transmembrane anterior posterior transformation 1b Neighboring gene LIM domain binding 2b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Expression of the zebrafish CD133/prominin1 genes in cellular proliferation zones in the embryonic central nervous system and sensory organs. McGrail M, et al. Dev Dyn, 2010 Jun. PMID 20503380
    2. Spatial distribution of prominin-1 (CD133)-positive cells within germinative zones of the vertebrate brain. Jászai J, et al. PLoS One, 2013. PMID 23723983, Free PMC Article
    3. Distinct and conserved prominin-1/CD133-positive retinal cell populations identified across species. Jászai J, et al. PLoS One, 2011 Mar 2. PMID 21407811, Free PMC Article
    4. Prominins control ciliary length throughout the animal kingdom: New lessons from human prominin-1 and zebrafish prominin-3. Jászai J, et al. J Biol Chem, 2020 May 1. PMID 32201384, Free PMC Article
    5. Loss of Llgl1 in retinal neuroepithelia reveals links between apical domain size, Notch activity and neurogenesis. Clark BS, et al. Development, 2012 May. PMID 22492354, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables cholesterol binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within photoreceptor cell outer segment organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in apical plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cilium IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microvillus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in microvillus membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in prominosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    prominin 1 b; prominin-1
    Names
    prominin-like 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198071.1 → NP_932337.1  prominin 1 b precursor

      See identical proteins and their annotated locations for NP_932337.1

      Status: PROVISIONAL

      Source sequence(s)
      AF373869
      UniProtKB/TrEMBL
      Q90WI3
      Related
      ENSDARP00000112980.1, ENSDART00000134719.3
      Conserved Domains (1) summary
      pfam05478
      Location:35 → 835
      Prominin; Prominin

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      22712925..22757213 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021481345.1 → XP_021337020.1  prominin-1 isoform X8

      UniProtKB/TrEMBL
      A0A8M9QPR6
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 834
      Prominin

    2. XM_021481324.1 → XP_021336999.1  prominin-1 isoform X6

      UniProtKB/TrEMBL
      A0A8M9QH22
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 840
      Prominin

    3. XM_021481302.1 → XP_021336977.1  prominin-1 isoform X4

      UniProtKB/TrEMBL
      A0A8M9Q021
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 843
      Prominin

    4. XM_021481317.1 → XP_021336992.1  prominin-1 isoform X5

      UniProtKB/TrEMBL
      A0A8M9Q036
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 842
      Prominin

    5. XM_021481260.1 → XP_021336935.1  prominin-1 isoform X2

      UniProtKB/TrEMBL
      A0A8M9QPL4
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 848
      Prominin

    6. XM_021481275.1 → XP_021336950.1  prominin-1 isoform X3

      UniProtKB/TrEMBL
      A0A8M9QPM2
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 845
      Prominin

    7. XM_021481233.1 → XP_021336908.1  prominin-1 isoform X1

      UniProtKB/TrEMBL
      A0A8M9QBM3
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 851
      Prominin

    8. XM_005170913.3 → XP_005170970.1  prominin-1 isoform X7

      UniProtKB/TrEMBL
      A0A8M2BI60
      Conserved Domains (1) summary
      pfam05478
      Location:37 → 851
      Prominin; Prominin

    Reference GRCz11 ALT_DRER_TU_1

    Genomic

    1. NW_018394480.1 Reference GRCz11 ALT_DRER_TU_1

      Range
      47280..91394 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395214.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      39288..83080 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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