pds5a PDS5 cohesin associated factor A [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: pds5aprovided by ZNC
Official Full Name: PDS5 cohesin associated factor Aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-1612
See related: Ensembl:ENSDARG00000055022 AllianceGenome:ZFIN:ZDB-GENE-040426-1612
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: Aprin; zgc:66331; zgc:153878
Summary: Predicted to be involved in DNA repair; mitotic sister chromatid cohesion; and negative regulation of DNA replication. Predicted to act upstream of or within cell division. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in chromatin and nucleus. Orthologous to human PDS5A (PDS5 cohesin associated factor A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 1

Exon count:: 33

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	1	NC_007112.7 (23323298..23370534, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	1	NC_007112.6 (22632559..22679820, complement)

Chromosome 1 - NC_007112.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fb75e08.y1 (e-PCR)
- UniSTS:191251

fi32b08.y1 (e-PCR)
- UniSTS:197277

fb78g06.x1 (e-PCR)
- UniSTS:191450

fc05g06.y1 (e-PCR)
- UniSTS:192218

fc15e08.x1 (e-PCR)
- UniSTS:192735

fc15e08.x1 (e-PCR)
- UniSTS:192736

Gene Ontology Provided by ZFIN

Process	Evidence Code	Pubs
involved_in DNA repair	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within cell cycle	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell division	IEA Inferred from Electronic Annotation more info
involved_in mitotic sister chromatid cohesion	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within mitotic sister chromatid cohesion	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of DNA replication	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: sister chromatid cohesion protein PDS5 homolog A

Names: PDS5, regulator of cohesion maintenance, homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_200992.2 → NP_957286.2 sister chromatid cohesion protein PDS5 homolog A

See identical proteins and their annotated locations for NP_957286.2

Status: PROVISIONAL

Source sequence(s)

BC129035

UniProtKB/Swiss-Prot

A1L1F4

Related

ENSDARP00000109877.2, ENSDART00000126785.4

Conserved Domains (2) summary

pfam06614
Location:1220 → 1317

Neuromodulin; Neuromodulin

sd00044
Location:278 → 308

HEAT; HEAT repeat [structural motif]

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007112.7 Reference GRCz11 Primary Assembly

Range

23323298..23370534 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005170916.4 → XP_005170973.1 sister chromatid cohesion protein PDS5 homolog A isoform X1

UniProtKB/TrEMBL

A0A8M2BI71, F1QDE7

Conserved Domains (2) summary

pfam06614
Location:1221 → 1318

Neuromodulin; Neuromodulin

sd00044
Location:279 → 309

HEAT; HEAT repeat [structural motif]