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    tram2 translocation associated membrane protein 2 [ Danio rerio (zebrafish) ]

    Gene ID: 406344, updated on 11-Apr-2024

    Summary

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    Official Symbol
    tram2provided by ZNC
    Official Full Name
    translocation associated membrane protein 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040426-2024
    See related
    Ensembl:ENSDARG00000030092 AllianceGenome:ZFIN:ZDB-GENE-040426-2024
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:55869; zgc:76937; wu:fb20c11; wu:fi23a12; zgc:111902
    Summary
    Predicted to be involved in protein insertion into ER membrane. Predicted to act upstream of or within SRP-dependent cotranslational protein targeting to membrane, translocation. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be integral component of endoplasmic reticulum membrane. Is expressed in hatching gland; notochord; polster; and splanchnocranium. Orthologous to human TRAM2 (translocation associated membrane protein 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See tram2 in Genome Data Viewer
    Location:
    chromosome: 20
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 20 NC_007131.7 (48116447..48139941)
    105 previous assembly GRCz10 (GCF_000002035.5) 20 NC_007131.6 (47639142..47662635)

    Chromosome 20 - NC_007131.7Genomic Context describing neighboring genes Neighboring gene PR domain containing 1c, with ZNF domain Neighboring gene XK related 5a Neighboring gene EF-hand domain (C-terminal) containing 1 Neighboring gene protein eva-1 homolog A-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    2. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    3. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article
    4. Gene evolution and gene expression after whole genome duplication in fish: the PhyloFish database. Pasquier J, et al. BMC Genomics, 2016 May 18. PMID 27189481, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC111902

    Gene Ontology Provided by ZFIN

    Process Evidence Code Pubs
    acts_upstream_of_or_within SRP-dependent cotranslational protein targeting to membrane, translocation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein insertion into ER membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    translocating chain-associated membrane protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_213071.1 → NP_998236.1  translocating chain-associated membrane protein 2

      See identical proteins and their annotated locations for NP_998236.1

      Status: PROVISIONAL

      Source sequence(s)
      BC046900
      UniProtKB/TrEMBL
      A0A8M1PNJ3, Q802X7
      Related
      ENSDARP00000043937.6, ENSDART00000043938.9
      Conserved Domains (2) summary
      pfam03798
      Location:113 → 312
      TRAM_LAG1_CLN8; TLC domain
      pfam08390
      Location:49 → 110
      TRAM1; TRAM1-like protein

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007131.7 Reference GRCz11 Primary Assembly

      Range
      48116447..48139941
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005173812.3 → XP_005173869.1  translocating chain-associated membrane protein 2 isoform X1

      UniProtKB/TrEMBL
      A0A8M2BL48
      Conserved Domains (2) summary
      pfam03798
      Location:113 → 312
      TRAM_LAG1_CLN8; TLC domain
      pfam08390
      Location:49 → 110
      TRAM1; TRAM1-like protein
    Nucleotide Protein Strain
    Heading Accession and Version

    Gene LinkOut

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