tfap2c transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma) [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: tfap2cprovided by ZNC
Official Full Name: transcription factor AP-2 gamma (activating enhancer binding protein 2 gamma)provided by ZNC
Primary source: ZFIN:ZDB-GENE-041212-61
See related: Ensembl:ENSDARG00000040606 AllianceGenome:ZFIN:ZDB-GENE-041212-61
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fb48g05; fb49c04; zgc:92088; wu:fb48g05; wu:fb49c04
Summary: Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Acts upstream of or within neural crest cell differentiation; olfactory placode development; and otic placode formation. Predicted to be active in nucleus. Is expressed in several structures, including ectoderm; epidermis; eye; neurogenic field; and presumptive ectoderm. Orthologous to human TFAP2C (transcription factor AP-2 gamma). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (56141788..56179707)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (56157640..56195515)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

We genetically ablate the neural crest (NC) using double mutants of tfap2a;tfap2c or remove specific subsets of the NC with sox10 and mitfa knockouts and characterise genome-wide gene expression levels across multiple time points.
Title: The gene regulatory basis of genetic compensation during neural crest induction.
Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos.
Title: Redundant activities of Tfap2a and Tfap2c are required for neural crest induction and development of other non-neural ectoderm derivatives in zebrafish embryos.

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General gene information

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Markers

fd09e07.y1 (e-PCR)
- UniSTS:195073

z19665 (e-PCR), detects polymorphism
- UniSTS:238970

fl03g05.x1 (e-PCR)
- UniSTS:201876

fb49c04.x1 (e-PCR)
- UniSTS:203239

AI497528 (e-PCR)
- UniSTS:206331

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in anatomical structure development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within ectodermal placode development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within ectodermal placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within neural crest cell fate specification	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within olfactory placode development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within otic placode formation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor AP-2 gamma

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001008576.2 → NP_001008576.1 transcription factor AP-2 gamma

See identical proteins and their annotated locations for NP_001008576.1

Status: VALIDATED

Source sequence(s)

CU468952

UniProtKB/TrEMBL

A0A8M1N383, Q5PQZ4

Related

ENSDARP00000123798.1, ENSDART00000150219.2

Conserved Domains (1) summary

pfam03299
Location:215 → 415

TF_AP-2; Transcription factor AP-2

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007117.7 Reference GRCz11 Primary Assembly

Range

56141788..56179707

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_017356481.2 → XP_017211970.1 transcription factor AP-2 gamma isoform X2

UniProtKB/TrEMBL

A0A8M6YYQ6
XM_021476853.1 → XP_021332528.1 transcription factor AP-2 gamma isoform X3

UniProtKB/TrEMBL

A0A8M9PZP3

Conserved Domains (1) summary

pfam03299
Location:210 → 404

TF_AP-2; Transcription factor AP-2
XM_021476852.1 → XP_021332527.1 transcription factor AP-2 gamma isoform X1

UniProtKB/TrEMBL

A0A8M9PM23

Conserved Domains (1) summary

pfam03299
Location:216 → 410

TF_AP-2; Transcription factor AP-2