Abcc4 ATP-binding cassette, sub-family C member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Abcc4provided by MGI
Official Full Name: ATP-binding cassette, sub-family C member 4provided by MGI
Primary source: MGI:MGI:2443111
See related: Ensembl:ENSMUSG00000032849 AllianceGenome:MGI:2443111
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MRP4; MOATB; ABCC4-N1; D630049P08Rik
Summary: Predicted to enable several functions, including ABC-type transporter activity; glutathione transmembrane transporter activity; and prostaglandin transmembrane transporter activity. Predicted to be involved in export across plasma membrane and organic anion transport. Predicted to act upstream of or within cilium assembly and prostaglandin secretion. Located in apical plasma membrane and basolateral plasma membrane. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Orthologous to human ABCC4 (ATP binding cassette subfamily C member 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in kidney adult (RPKM 9.2), bladder adult (RPKM 8.4) and 21 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 E4; 14 62.24 cM

Exon count:: 34

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (118720104..118945475, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (118482692..118707856, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
Title: ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity.
ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target.
Title: ABCC4 is a PGE2 efflux transporter in the ovarian follicle: A mediator of ovulation and a potential non-hormonal contraceptive target.
Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.
Title: Role of Membrane Lipid Rafts in MRP4 (ABCC4) Dependent Regulation of the cAMP Pathway in Blood Platelets.
Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
Title: Transporter Activity Changes in Nonalcoholic Steatohepatitis: Assessment with Plasma Coproporphyrin I and III.
An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
Title: An ABC Transporter Drives Medulloblastoma Pathogenesis by Regulating Sonic Hedgehog Signaling.
cyclic AMP efflux via MRP4 plays an essential role in mouse sperm capacitation.
Title: MRP4-mediated cAMP efflux is essential for mouse spermatozoa capacitation.
TNFalpha induces hepatic MRP4 expression through activation of the p38-E2F1-Nrf2 signaling pathway.
Title: TNFα Induces Multidrug Resistance-Associated Protein 4 Expression through p38-E2F1-Nrf2 Signaling in Obstructive Cholestasis.
The diversity at N-termini in these protein isoforms explains the diverse function of ABCC4 in mouse.
Title: A novel exon generates ubiquitously expressed alternatively spliced new transcript of mouse Abcc4 gene.
ABCC4 plays a protective role against cytarabine-mediated insults in leukemic and host myeloid cells.
Title: ABCC4 Is a Determinant of Cytarabine-Induced Cytotoxicity and Myelosuppression.
P-gp, Bcrp, Mrp1 and Mrp4 are differentially expressed at the outer and inner blood retinal barrier, resulting in an altered ability to limit substrate distribution at the retina as compared with the blood brain barrier
Title: Blood-brain and retinal barriers show dissimilar ABC transporter impacts and concealed effect of P-glycoprotein on a novel verapamil influx carrier.

Submit: New GeneRIF Correction See all GeneRIFs (40)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Gene trapped (4) 1 citation
Targeted (2) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Abcc4 (e-PCR), detects polymorphism
- UniSTS:506698

D14Mit275 (e-PCR), detects polymorphism
- UniSTS:127384

NoName (e-PCR)
- UniSTS:237247

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ABC-type bile acid transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type glutathione S-conjugate transporter activity	ISO Inferred from Sequence Orthology more info
enables ABC-type transporter activity	IEA Inferred from Electronic Annotation more info
enables ABC-type xenobiotic transporter activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATPase-coupled transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables ATPase-coupled transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables alcohol transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables efflux transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables glutathione transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables guanine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables prostaglandin transmembrane transporter activity	ISO Inferred from Sequence Orthology more info	PubMed
enables purine nucleotide transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables urate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables xenobiotic transmembrane transporter activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in bile acid and bile salt transport	ISO Inferred from Sequence Orthology more info
involved_in cAMP transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cilium assembly	ISO Inferred from Sequence Orthology more info	PubMed
involved_in export across plasma membrane	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within fatty acid derivative transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in leukotriene transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within lipid transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within organic hydroxy compound transport	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of smooth muscle cell proliferation	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within prostaglandin secretion	ISO Inferred from Sequence Orthology more info	PubMed
involved_in prostaglandin transport	ISO Inferred from Sequence Orthology more info
involved_in transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in urate transport	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within xenobiotic transmembrane transport	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in basolateral plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in basolateral plasma membrane	ISO Inferred from Sequence Orthology more info
NOT located_in cilium	IDA Inferred from Direct Assay more info	PubMed
located_in external side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info	PubMed
located_in platelet dense granule membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ATP-binding cassette sub-family C member 4

Names: ATP-binding cassette, sub-family C (CFTR/MRP), member 4; multidrug resistance-associated protein 4

NP_001028508.2

EC 7.6.2.2

EC 7.6.2.3

NP_001157147.1

EC 7.6.2.2

EC 7.6.2.3

NP_001157148.1

EC 7.6.2.2

EC 7.6.2.3

XP_006519073.1

EC 7.6.2.2

EC 7.6.2.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001033336.3 → NP_001028508.2 ATP-binding cassette sub-family C member 4 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).

Source sequence(s)

AC154419, AC167668, AK157723, CT025694

Consensus CDS

CCDS27335.1

UniProtKB/Swiss-Prot

A0A1C9IC75, B7ZWC5, E9Q236, Q3TZN9

UniProtKB/TrEMBL

B9EKC2

Related

ENSMUSP00000042186.7, ENSMUST00000036554.14

Conserved Domains (1) summary

PLN03130
Location:12 → 1284

PLN03130; ABC transporter C family member; Provisional
NM_001163675.1 → NP_001157147.1 ATP-binding cassette sub-family C member 4 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and initiates translation at a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus compared to isoform 1.

Source sequence(s)

AC154419, AC167668, AK032802, AK052778, AK157723

UniProtKB/TrEMBL

B9EKC2

Related

ENSMUST00000226703.2

Conserved Domains (5) summary

cd03244
Location:996 → 1215

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:367 → 567

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

TIGR01271
Location:8 → 1226

CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

pfam00664
Location:675 → 948

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:53 → 322

ABC_membrane; ABC transporter transmembrane region
NM_001163676.1 → NP_001157148.1 ATP-binding cassette sub-family C member 4 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.

Source sequence(s)

AC154419, AC167668, CT025694

Consensus CDS

CCDS49565.1

UniProtKB/TrEMBL

B9EKC2, E9Q467

Related

ENSMUSP00000129677.2, ENSMUST00000166646.2

Conserved Domains (5) summary

cd03244
Location:964 → 1183

ABCC_MRP_domain2; ATP-binding cassette domain 2 of multidrug resistance-associated protein

cd03250
Location:335 → 535

ABCC_MRP_domain1; ATP-binding cassette domain 1 of multidrug resistance-associated protein, subfamily C

TIGR01271
Location:11 → 1194

CFTR_protein; cystic fibrosis transmembrane conductor regulator (CFTR)

pfam00664
Location:643 → 916

ABC_membrane; ABC transporter transmembrane region

cl00549
Location:104 → 290

ABC_membrane; ABC transporter transmembrane region

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

118720104..118945475 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006519010.5 → XP_006519073.1 ATP-binding cassette sub-family C member 4 isoform X1

Conserved Domains (2) summary

PLN03130
Location:12 → 818

PLN03130; ABC transporter C family member; Provisional

cd18593
Location:94 → 386

ABC_6TM_MRP4_D1_like; Six-transmembrane helical domain 1 (TMD1) of multidrug resistance-associated protein 4 (MRP4) and similar proteins