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    Qrich1 glutamine-rich 1 [ Mus musculus (house mouse) ]

    Gene ID: 69232, updated on 12-May-2024

    Summary

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    Official Symbol
    Qrich1provided by MGI
    Official Full Name
    glutamine-rich 1provided by MGI
    Primary source
    MGI:MGI:1916482
    See related
    Ensembl:ENSMUSG00000006673 AllianceGenome:MGI:1916482
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    b2b2404Clo; 2610028H07Rik
    Summary
    Predicted to enable DNA binding activity. Involved in response to endoplasmic reticulum stress. Acts upstream of or within kidney development. Predicted to be located in nucleoplasm. Is expressed in female reproductive system and urinary system. Orthologous to human QRICH1 (glutamine rich 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 54.1), ovary adult (RPKM 39.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Qrich1 in Genome Data Viewer
    Location:
    9 F2; 9 59.45 cM
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (108394010..108437366)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (108516982..108560167)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2916 Neighboring gene ubiquitin specific peptidase 19 Neighboring gene STARR-positive B cell enhancer ABC_E3860 Neighboring gene glutaminyl-tRNA synthetase 1 Neighboring gene STARR-positive B cell enhancer ABC_E3861 Neighboring gene STARR-positive B cell enhancer ABC_E3862 Neighboring gene inosine monophosphate dehydrogenase 2 Neighboring gene NADH:ubiquinone oxidoreductase complex assembly factor 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. QRICH1 mutations cause a chondrodysplasia with developmental delay. Lui JC, et al. Clin Genet, 2019 Jan. PMID 30281152, Free PMC Article
    2. QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis. You K, et al. Science, 2021 Jan 1. PMID 33384352, Free PMC Article
    3. Genetic link between renal birth defects and congenital heart disease. San Agustin JT, et al. Nat Commun, 2016 Mar 22. PMID 27002738, Free PMC Article
    4. Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice. Nakahara M, et al. Mamm Genome, 2013 Jun. PMID 23604909
    5. Global genetic analysis in mice unveils central role for cilia in congenital heart disease. Li Y, et al. Nature, 2015 May 28. PMID 25807483, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
      Title: QRICH1 dictates the outcome of ER stress through transcriptional control of proteostasis.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Targeted (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in PERK-mediated unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum unfolded protein response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in integrated stress response signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within kidney development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to endoplasmic reticulum stress IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to endoplasmic reticulum stress ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to unfolded protein IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    transcriptional regulator QRICH1
    Names
    glutamine-rich protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001114119.1 → NP_001107591.1  transcriptional regulator QRICH1

      See identical proteins and their annotated locations for NP_001107591.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK151491, BB851544, BF658891, CT010508
      Consensus CDS
      CCDS52927.1
      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Related
      ENSMUSP00000006851.9, ENSMUST00000006851.15
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    2. NM_175143.5 → NP_780352.2  transcriptional regulator QRICH1

      See identical proteins and their annotated locations for NP_780352.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant lacks an exon in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.
      Source sequence(s)
      AK151491, BB851544, BC120916, BF658891
      Consensus CDS
      CCDS52927.1
      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Related
      ENSMUSP00000107782.4, ENSMUST00000112155.9
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      108394010..108437366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006511809.4 → XP_006511872.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511872.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    2. XM_030244560.2 → XP_030100420.1  transcriptional regulator QRICH1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UA37
      Conserved Domains (1) summary
      pfam12012
      Location:507 → 667
      DUF3504; Domain of unknown function (DUF3504)

    3. XM_006511808.4 → XP_006511871.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511871.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    4. XM_017313561.3 → XP_017169050.1  transcriptional regulator QRICH1 isoform X4

      Conserved Domains (2) summary
      pfam12012
      Location:256 → 416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:6 → 45
      DD; Death Domain Superfamily of protein-protein interaction domains

    5. XM_006511813.4 → XP_006511876.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511876.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    6. XM_006511812.3 → XP_006511875.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511875.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    7. XM_006511811.5 → XP_006511874.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511874.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    8. XM_006511814.3 → XP_006511877.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511877.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    9. XM_006511818.2 → XP_006511881.1  transcriptional regulator QRICH1 isoform X4

      See identical proteins and their annotated locations for XP_006511881.1

      Conserved Domains (2) summary
      pfam12012
      Location:256 → 416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:6 → 45
      DD; Death Domain Superfamily of protein-protein interaction domains

    10. XM_036155242.1 → XP_036011135.1  transcriptional regulator QRICH1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UA37
      Conserved Domains (1) summary
      pfam12012
      Location:507 → 667
      DUF3504; Domain of unknown function (DUF3504)

    11. XM_006511810.4 → XP_006511873.1  transcriptional regulator QRICH1 isoform X1

      See identical proteins and their annotated locations for XP_006511873.1

      UniProtKB/Swiss-Prot
      Q3UA37
      UniProtKB/TrEMBL
      G3X8R5
      Conserved Domains (2) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
      pfam12012
      Location:606 → 759
      DUF3504; Domain of unknown function (DUF3504)

    12. XM_036155244.1 → XP_036011137.1  transcriptional regulator QRICH1 isoform X4

      Conserved Domains (2) summary
      pfam12012
      Location:256 → 416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:6 → 45
      DD; Death Domain Superfamily of protein-protein interaction domains

    13. XM_017313560.3 → XP_017169049.1  transcriptional regulator QRICH1 isoform X2

      UniProtKB/Swiss-Prot
      Q3UA37
      Conserved Domains (1) summary
      pfam12012
      Location:507 → 667
      DUF3504; Domain of unknown function (DUF3504)

    14. XM_030244561.2 → XP_030100421.1  transcriptional regulator QRICH1 isoform X4

      Conserved Domains (2) summary
      pfam12012
      Location:256 → 416
      DUF3504; Domain of unknown function (DUF3504)
      cl14633
      Location:6 → 45
      DD; Death Domain Superfamily of protein-protein interaction domains

    15. XM_036155243.1 → XP_036011136.1  transcriptional regulator QRICH1 isoform X3

      UniProtKB/TrEMBL
      Q8BUN3
      Related
      ENSMUSP00000141267.2, ENSMUST00000193258.6
      Conserved Domains (1) summary
      cd01671
      Location:6 → 45
      CARD; Caspase activation and recruitment domain: a protein-protein interaction domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3UA37.1 GenPept UniProtKB/Swiss-Prot:Q3UA37

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