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    Zc3h4 zinc finger CCCH-type containing 4 [ Mus musculus (house mouse) ]

    Gene ID: 330474, updated on 22-May-2024

    Summary

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    Official Symbol
    Zc3h4provided by MGI
    Official Full Name
    zinc finger CCCH-type containing 4provided by MGI
    Primary source
    MGI:MGI:2682314
    See related
    Ensembl:ENSMUSG00000059273 AllianceGenome:MGI:2682314
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Bwq1; Gm768; Kiaa1064-hp
    Summary
    Predicted to enable metal ion binding activity. Predicted to be located in cytosol and nucleoplasm. Predicted to be active in nucleus. Is expressed in several structures, including early conceptus; oocyte; retina; and telencephalon. Orthologous to human ZC3H4 (zinc finger CCCH-type containing 4). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in thymus adult (RPKM 20.9), spleen adult (RPKM 16.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zc3h4 in Genome Data Viewer
    Location:
    7 A2; 7 9.03 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (16132549..16171621)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (16399583..16437696)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_18129 Neighboring gene STARR-seq mESC enhancer starr_18130 Neighboring gene BCL2 binding component 3 Neighboring gene SUMO1 activating enzyme subunit 1 Neighboring gene predicted gene, 57781 Neighboring gene STARR-seq mESC enhancer starr_18132 Neighboring gene STARR-positive B cell enhancer ABC_E4898 Neighboring gene STARR-seq mESC enhancer starr_18133 Neighboring gene STARR-positive B cell enhancer ABC_E347 Neighboring gene transmembrane protein 160 Neighboring gene neuronal PAS domain protein 1 Neighboring gene nuclear encoded rRNA 5S 151

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop. Ghafoor H, et al. Toxicol Appl Pharmacol, 2022 Jan 15. PMID 34979141
    2. The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition. Jiang R, et al. Toxicol Lett, 2019 Jun 1. PMID 30826420
    3. Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation. Yang X, et al. FASEB J, 2018 Jun. PMID 29401612
    4. Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition. Jiang R, et al. Lab Invest, 2020 Jul. PMID 32218530
    5. A first exon termination checkpoint preferentially suppresses extragenic transcription. Austenaa LMI, et al. Nat Struct Mol Biol, 2021 Apr. PMID 33767452, Free PMC Article

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZC3H4 governs epithelial cell migration through ROCK/p-PYK2/p-MLC2 pathway in silica-induced pulmonary fibrosis.
      Title: ZC3H4 governs epithelial cell migration through ROCK/p-PYK2/p-MLC2 pathway in silica-induced pulmonary fibrosis.
    2. ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop.
      Title: ZC3H4 promotes pulmonary fibrosis via an ER stress-related positive feedback loop.
    3. ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential for early embryogenesis in micedagger.
      Title: ZC3H4-a novel Cys-Cys-Cys-His-type zinc finger protein-is essential for early embryogenesis in mice†.
    4. Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition.
      Title: Elk-1 transcriptionally regulates ZC3H4 expression to promote silica-induced epithelial-mesenchymal transition.
    5. may act as a novel regulator in the progression of SiO2-induced epithelial to mesenchymal transition
      Title: The emerging roles of a novel CCCH-type zinc finger protein, ZC3H4, in silica-induced epithelial to mesenchymal transition.
    6. study elucidates a link between SiO2-induced macrophage activation and the circZC3H4 RNA/ZC3H4 pathway, thereby providing novel insight into the potential use of ZC3H4 to develop novel therapeutic strategies for silicosis.
      Title: Silica-induced initiation of circular ZC3H4 RNA/ZC3H4 pathway promotes the pulmonary macrophage activation.
    Submit: New GeneRIF Correction

    Phenotypes

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    Associated conditions

    Description Tests
    body weight QTL 1
    GeneReviews: Not available

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1064, MGC67629

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA-templated transcription termination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in lncRNA catabolic process IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in lncRNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription, elongation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of DNA-templated transcription, elongation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of lncRNA transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of lncRNA transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nuclear RNA surveillance IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nuclear RNA surveillance ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger CCCH domain-containing protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427310.1 → NP_001414239.1  zinc finger CCCH domain-containing protein 4 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC164880
      UniProtKB/Swiss-Prot
      Q6ZPZ3
      Related
      ENSMUSP00000159993.1, ENSMUST00000249896.1

    2. NM_001427311.1 → NP_001414240.1  zinc finger CCCH domain-containing protein 4 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC164880

    3. NM_001427312.1 → NP_001414241.1  zinc finger CCCH domain-containing protein 4 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC164880

    4. NM_001427313.1 → NP_001414242.1  zinc finger CCCH domain-containing protein 4 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC164880
      UniProtKB/TrEMBL
      A0A1B0GRU3
      Related
      ENSMUSP00000147665.2, ENSMUST00000209289.2

    5. NM_198631.2 → NP_941033.2  zinc finger CCCH domain-containing protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC164880, AK129275, BC057627, BC060274, BY167917, CF538051, CJ101946, CN667093
      Consensus CDS
      CCDS52040.1
      UniProtKB/TrEMBL
      E9Q8K8
      Related
      ENSMUSP00000096386.4, ENSMUST00000098789.5
      Conserved Domains (2) summary
      smart00356
      Location:371 → 395
      ZnF_C3H1; zinc finger
      pfam13376
      Location:724 → 749
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      16132549..16171621
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153177.1 → XP_036009070.1  zinc finger CCCH domain-containing protein 4 isoform X2

      Conserved Domains (5) summary
      smart00356
      Location:401 → 425
      ZnF_C3H1; zinc finger
      PHA03247
      Location:974 → 1260
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:427 → 449
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13376
      Location:754 → 779
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated
      pfam18044
      Location:374 → 395
      zf-CCCH_4; CCCH-type zinc finger

    2. XM_006540106.5 → XP_006540169.1  zinc finger CCCH domain-containing protein 4 isoform X6

      Conserved Domains (4) summary
      smart00356
      Location:420 → 444
      ZnF_C3H1; zinc finger
      PHA03247
      Location:910 → 1196
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:446 → 467
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18044
      Location:393 → 414
      zf-CCCH_4; CCCH-type zinc finger

    3. XM_006540102.5 → XP_006540165.1  zinc finger CCCH domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006540165.1

      UniProtKB/Swiss-Prot
      Q6ZPZ3
      Conserved Domains (5) summary
      smart00356
      Location:420 → 444
      ZnF_C3H1; zinc finger
      PHA03247
      Location:993 → 1279
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:446 → 467
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18044
      Location:393 → 414
      zf-CCCH_4; CCCH-type zinc finger
      pfam13376
      Location:773 → 798
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated

    4. XM_006540107.5 → XP_006540170.1  zinc finger CCCH domain-containing protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006540170.1

      UniProtKB/Swiss-Prot
      Q6ZPZ3
      Conserved Domains (5) summary
      smart00356
      Location:420 → 444
      ZnF_C3H1; zinc finger
      PHA03247
      Location:993 → 1279
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:446 → 467
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18044
      Location:393 → 414
      zf-CCCH_4; CCCH-type zinc finger
      pfam13376
      Location:773 → 798
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated

    5. XM_011250604.4 → XP_011248906.1  zinc finger CCCH domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_011248906.1

      Conserved Domains (5) summary
      smart00356
      Location:379 → 403
      ZnF_C3H1; zinc finger
      PHA03247
      Location:952 → 1238
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:405 → 427
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13376
      Location:732 → 757
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated
      pfam18044
      Location:352 → 373
      zf-CCCH_4; CCCH-type zinc finger

    6. XM_006540103.5 → XP_006540166.1  zinc finger CCCH domain-containing protein 4 isoform X3

      Conserved Domains (5) summary
      smart00356
      Location:384 → 408
      ZnF_C3H1; zinc finger
      PHA03247
      Location:957 → 1243
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:410 → 431
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18044
      Location:357 → 378
      zf-CCCH_4; CCCH-type zinc finger
      pfam13376
      Location:737 → 762
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated

    7. XM_006540104.4 → XP_006540167.1  zinc finger CCCH domain-containing protein 4 isoform X4

      See identical proteins and their annotated locations for XP_006540167.1

      Conserved Domains (5) summary
      smart00356
      Location:379 → 403
      ZnF_C3H1; zinc finger
      PHA03247
      Location:952 → 1238
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:405 → 427
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13376
      Location:732 → 757
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated
      pfam18044
      Location:352 → 373
      zf-CCCH_4; CCCH-type zinc finger

    8. XM_006540105.4 → XP_006540168.1  zinc finger CCCH domain-containing protein 4 isoform X5

      Conserved Domains (5) summary
      smart00356
      Location:374 → 398
      ZnF_C3H1; zinc finger
      PHA03247
      Location:947 → 1233
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:400 → 421
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam18044
      Location:347 → 368
      zf-CCCH_4; CCCH-type zinc finger
      pfam13376
      Location:727 → 752
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated

    9. XM_036153178.1 → XP_036009071.1  zinc finger CCCH domain-containing protein 4 isoform X4

      Conserved Domains (5) summary
      smart00356
      Location:379 → 403
      ZnF_C3H1; zinc finger
      PHA03247
      Location:952 → 1238
      PHA03247; large tegument protein UL36; Provisional
      pfam00642
      Location:405 → 427
      zf-CCCH; Zinc finger C-x8-C-x5-C-x3-H type (and similar)
      pfam13376
      Location:732 → 757
      OmdA; Bacteriocin-protection, YdeI or OmpD-Associated
      pfam18044
      Location:352 → 373
      zf-CCCH_4; CCCH-type zinc finger
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6ZPZ3.2 GenPept UniProtKB/Swiss-Prot:Q6ZPZ3

    Gene LinkOut

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