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    Tspyl2 TSPY-like 2 [ Mus musculus (house mouse) ]

    Gene ID: 52808, updated on 8-May-2024

    Summary

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    Official Symbol
    Tspyl2provided by MGI
    Official Full Name
    TSPY-like 2provided by MGI
    Primary source
    MGI:MGI:106244
    See related
    Ensembl:ENSMUSG00000041096 AllianceGenome:MGI:106244
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    CDA1; CINAP; DENTT; DXBwg1396e; DXHXS1008E; E130307F10Rik
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA replication; negative regulation of cell growth; and regulation of protein kinase activity. Predicted to act upstream of or within chromatin organization. Predicted to be located in nucleolus. Predicted to be active in chromatin and nucleus. Is expressed in several structures, including alimentary system; genitourinary system; heart; nervous system; and sensory organ. Orthologous to human TSPYL2 (TSPY like 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in cerebellum adult (RPKM 34.8), frontal lobe adult (RPKM 34.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tspyl2 in Genome Data Viewer
    Location:
    X F3; X 68.46 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) X NC_000086.8 (151119847..151125480, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) X NC_000086.7 (152336851..152342484, complement)

    Chromosome X - NC_000086.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_48091 Neighboring gene lysine demethylase 5C Neighboring gene STARR-seq mESC enhancer starr_48092 Neighboring gene STARR-seq mESC enhancer starr_48093 Neighboring gene Kdm5c adjacent non-coding transcript Neighboring gene STARR-positive B cell enhancer mm9_chrX:148771022-148771323 Neighboring gene G-protein coupled receptor 173 Neighboring gene RIKEN cDNA 3010001F23 gene Neighboring gene STARR-seq mESC enhancer starr_48095 Neighboring gene actin, beta pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation. Zhuge R, et al. Cell Rep, 2023 Jan 31. PMID 36640330
    2. Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice. Li Q, et al. Behav Genet, 2016 Jul. PMID 26826030, Free PMC Article
    3. Withdrawal of skeletal muscle cells from cell cycle progression triggers differentiation of Toxoplasma gondii towards the bradyzoite stage. Swierzy IJ, et al. Cell Microbiol, 2015 Jan. PMID 25131712
    4. TSPYL2 is important for G1 checkpoint maintenance upon DNA damage. Tao KP, et al. PLoS One, 2011. PMID 21738728, Free PMC Article
    5. Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development. Ozbun LL, et al. Dev Dyn, 2003 Mar. PMID 12619135

    See all (33) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation.
      Title: hCINAP regulates the differentiation of embryonic stem cells by regulating NEDD4 liquid-liquid phase-separation-mediated YAP1 activation.
    2. TSPYL2 is recruited to promoters of specific EZH2 target genes in neurons.
      Title: TSPYL2 Regulates the Expression of EZH2 Target Genes in Neurons.
    3. Homozygous CINAP-/- mice show embryonic lethality. The heterozygotes are viable and show defects in 18S rRNA processing.
      Title: The ATPase hCINAP regulates 18S rRNA processing and is essential for embryogenesis and tumour growth.
    4. The identification that diabetes is associated with upregulation of vascular CDA1 and that CDA1 deletion in diabetic mice promotes aneurysm formation provides evidence that CDA1 plays a role in diabetes to reduce susceptibility to aneurysm formation.
      Title: Diabetes Reduces Severity of Aortic Aneurysms Depending on the Presence of Cell Division Autoantigen 1 (CDA1).
    5. These findings suggest that disrupting Tspyl2 gene expression leads to behavioral and brain morphological alterations that mirror a number of neurodevelopmental psychiatric traits.
      Title: Tspyl2 Loss-of-Function Causes Neurodevelopmental Brain and Behavior Abnormalities in Mice.
    6. Following infection with T. gondii, myotubes but not myoblasts or fibroblasts further upregulate the negative cell cycle regulator Tspyl2.
      Title: Withdrawal of skeletal muscle cells from cell cycle progression triggers differentiation of Toxoplasma gondii towards the bradyzoite stage.
    7. We conclude that TSPYL2 contributes to cognitive variability through regulating the expression of Grin2a and Grin2b.
      Title: The nucleosome assembly protein TSPYL2 regulates the expression of NMDA receptor subunits GluN2A and GluN2B.
    8. CDA1 deletion reduces but does not block renal TGF-beta signaling.
      Title: Genetic deletion of cell division autoantigen 1 retards diabetes-associated renal injury.
    9. TSPYL2 serves a biological role in maintaining the G1 checkpoint under stress condition.
      Title: TSPYL2 is important for G1 checkpoint maintenance upon DNA damage.
    10. DENTT may play multiple roles in modulating transcriptional responses suggesting new roles for the TTSN superfamily during embryogenesis and differentiation.
      Title: Differentially expressed nucleolar TGF-beta1 target (DENTT) in mouse development.
    Submit: New GeneRIF Correction See all GeneRIFs (12)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC40973

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA replication ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nucleosome assembly IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of protein kinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    testis-specific Y-encoded-like protein 2
    Names
    CASK interacting nucleosome assembly protein
    TSPY-like protein 2
    cell division autoantigen 1 nucleolar protein
    differentially expressed nucleolar TGF-beta1 target
    nucleolar TGF-beta1 target protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358369.1 → NP_001345298.1  testis-specific Y-encoded-like protein 2 isoform c

      Status: VALIDATED

      Source sequence(s)
      AL731727, AW046203
      Related
      ENSMUST00000138918.8
      Conserved Domains (1) summary
      pfam00956
      Location:209 → 388
      NAP; Nucleosome assembly protein (NAP)

    2. NM_029836.4 → NP_084112.1  testis-specific Y-encoded-like protein 2 isoform a

      See identical proteins and their annotated locations for NP_084112.1

      Status: VALIDATED

      Source sequence(s)
      AW046203, BC054393, BY008032, CJ066847
      Consensus CDS
      CCDS30474.1
      UniProtKB/Swiss-Prot
      Q6WRI3, Q7TQI8, Q9CU22
      Related
      ENSMUSP00000046782.7, ENSMUST00000044509.7
      Conserved Domains (1) summary
      cl08298
      Location:209 → 388
      NAP; Nucleosome assembly protein (NAP)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000086.8 Reference GRCm39 C57BL/6J

      Range
      151119847..151125480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_145936.3: Suppressed sequence

      Description
      NM_145936.3: This RefSeq was permanently suppressed because it is a nonsense-mediated decay (NMD) candidate.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7TQI8.1 GenPept UniProtKB/Swiss-Prot:Q7TQI8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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