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    Slc18b1 solute carrier family 18, subfamily B, member 1 [ Mus musculus (house mouse) ]

    Gene ID: 76306, updated on 9-May-2024

    Summary

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    Official Symbol
    Slc18b1provided by MGI
    Official Full Name
    solute carrier family 18, subfamily B, member 1provided by MGI
    Primary source
    MGI:MGI:1923556
    See related
    Ensembl:ENSMUSG00000037455 AllianceGenome:MGI:1923556
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    VPAT; 1110021L09Rik
    Summary
    Predicted to enable transmembrane transporter activity. Predicted to be located in membrane. Predicted to be integral component of membrane. Is expressed in dorsal root ganglion and spinal cord. Orthologous to human SLC18B1 (solute carrier family 18 member B1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in subcutaneous fat pad adult (RPKM 9.6), large intestine adult (RPKM 9.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Slc18b1 in Genome Data Viewer
    Location:
    10 A4; 10 11.12 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (23672876..23703867)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (23796859..23827969)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E2931 Neighboring gene small nucleolar RNA, C/D box 100 Neighboring gene predicted gene, 23130 Neighboring gene ribosomal protein S12 Neighboring gene STARR-seq mESC enhancer starr_26049 Neighboring gene STARR-seq mESC enhancer starr_26051 Neighboring gene STARR-positive B cell enhancer ABC_E8327 Neighboring gene STARR-seq mESC enhancer starr_26053 Neighboring gene vanin 3 Neighboring gene STARR-seq mESC enhancer starr_26055 Neighboring gene vanin 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The polyamine transporter Slc18b1(VPAT) is important for both short and long time memory and for regulation of polyamine content in the brain. Fredriksson R, et al. PLoS Genet, 2019 Dec. PMID 31800589, Free PMC Article
    2. Imaging inflammation using an activated macrophage probe with Slc18b1 as the activation-selective gating target. Park SJ, et al. Nat Commun, 2019 Mar 7. PMID 30846702, Free PMC Article
    3. Vesicular Polyamine Transporter Mediates Vesicular Storage and Release of Polyamine from Mast Cells. Takeuchi T, et al. J Biol Chem, 2017 Mar 3. PMID 28082679, Free PMC Article
    4. Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Coulpier F, et al. Glia, 2009 Oct. PMID 19243017
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1) 
    • Targeted (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables monoamine:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables polyamine:proton antiporter activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in serotonin uptake ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermidine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermidine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in spermine transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in spermine transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in secretory granule membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in synaptic vesicle membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    MFS-type transporter SLC18B1
    Names
    MFS-type transporter C6orf192 homolog
    solute carrier family 18 member B1
    vesicular polyamine transporter

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358812.2 → NP_001345741.1  MFS-type transporter SLC18B1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC153973, AC160147
      UniProtKB/Swiss-Prot
      D3Z5L6
      Conserved Domains (1) summary
      pfam07690
      Location:1 → 322
      MFS_1; Major Facilitator Superfamily

    2. NM_001358813.2 → NP_001345742.1  MFS-type transporter SLC18B1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153973, AC160147
      Conserved Domains (1) summary
      cl28910
      Location:3 → 190
      MFS; Major Facilitator Superfamily

    3. NM_001408212.1 → NP_001395141.1  MFS-type transporter SLC18B1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC153973, AC160147

    4. NM_001408213.1 → NP_001395142.1  MFS-type transporter SLC18B1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC153973, AC160147

    5. NM_001408214.1 → NP_001395143.1  MFS-type transporter SLC18B1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153973, AC160147

    6. NM_001408215.1 → NP_001395144.1  MFS-type transporter SLC18B1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC153973, AC160147

    7. NM_183116.3 → NP_898939.2  MFS-type transporter SLC18B1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC153973, AC160147
      Consensus CDS
      CCDS48521.1
      UniProtKB/Swiss-Prot
      D3Z5L6
      UniProtKB/TrEMBL
      E9PU92
      Related
      ENSMUSP00000112634.2, ENSMUST00000119597.8
      Conserved Domains (2) summary
      cd06174
      Location:37 → 426
      MFS; The Major Facilitator Superfamily (MFS) is a large and diverse group of secondary transporters that includes uniporters, symporters, and antiporters. MFS proteins facilitate the transport across cytoplasmic or internal membranes of a variety of ...
      pfam07690
      Location:48 → 392
      MFS_1; Major Facilitator Superfamily

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      23672876..23703867
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030245356.1 → XP_030101216.1  MFS-type transporter SLC18B1 isoform X2

      Conserved Domains (1) summary
      cl28910
      Location:3 → 190
      MFS; Major Facilitator Superfamily

    2. XM_030245355.1 → XP_030101215.1  MFS-type transporter SLC18B1 isoform X1

      Conserved Domains (1) summary
      cl28910
      Location:1 → 295
      MFS; Major Facilitator Superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    D3Z5L6.2 GenPept UniProtKB/Swiss-Prot:D3Z5L6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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