Srsf5 serine and arginine-rich splicing factor 5 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Srsf5provided by MGI
Official Full Name: serine and arginine-rich splicing factor 5provided by MGI
Primary source: MGI:MGI:98287
See related: Ensembl:ENSMUSG00000021134 AllianceGenome:MGI:98287
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Sfrs5
Summary: The protein encoded by this gene is a member of the serine/arginine (SR)-rich family of pre-mRNA splicing factors, which constitute part of the spliceosome. Each of these factors contains an RNA recognition motif (RRM) for binding RNA and an RS domain for binding other proteins. The RS domain is rich in serine and arginine residues and facilitates interaction between different SR splicing factors. In addition to being critical for mRNA splicing, the SR proteins have also been shown to be involved in mRNA export from the nucleus and in translation. [provided by RefSeq, Nov 2016]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 229.5), bladder adult (RPKM 197.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 D1; 12 37.2 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (80992308..80997277)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (80945495..80950507)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.
Title: SRSF5-Mediated Alternative Splicing of M Gene is Essential for Influenza A Virus Replication: A Host-Directed Target Against Influenza Virus.
CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Title: CPEB2 m6A methylation regulates blood-tumor barrier permeability by regulating splicing factor SRSF5 stability.
Posttranslational modification of SR proteins underlies the regulation of their mRNA export activities and distinguishes pluripotent from differentiated cells.
Title: Cellular differentiation state modulates the mRNA export activity of SR proteins.
overexpression of SRSF5 enhances a specific endogenous pre-mRNA splicing event in proliferating cells, but not in differentiating cells, due to proteasome-mediated targeting of both endogenous and transfection-derived SRSF5.
Title: Proteasome-mediated proteolysis of SRSF5 splicing factor intriguingly co-occurs with SRSF5 mRNA upregulation during late erythroid differentiation.
the effects of TGF-beta1 on FN splicing during chondrogenesis may be largely dependent on its effect on SRp40 isoform expression
Title: Transforming growth factor-beta1 regulates fibronectin isoform expression and splicing factor SRp40 expression during ATDC5 chondrogenic maturation.
Data show that Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of SRp40.
Title: Molecular and genetic studies imply Akt-mediated signaling promotes protein kinase CbetaII alternative splicing via phosphorylation of serine/arginine-rich splicing factor SRp40.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Sfrs5 (e-PCR), detects polymorphism
- UniSTS:479267

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RS domain binding	IPI Inferred from Physical Interaction more info	PubMed
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase B binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within RNA splicing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA splicing, via spliceosome	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in response to insulin	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within response to wounding	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
is_active_in nuclear speck	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear speck	IDA Inferred from Direct Assay more info	PubMed
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: serine/arginine-rich splicing factor 5

Names: delayed-early protein HRS; pre-mRNA-splicing factor SRP40; splicing factor, arginine/serine-rich 5 (SRp40, HRS)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001079694.3 → NP_001073162.1 serine/arginine-rich splicing factor 5 isoform 1

See identical proteins and their annotated locations for NP_001073162.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AA388848, AC125092, AK146624, BC082593

Consensus CDS

CCDS36484.1

UniProtKB/Swiss-Prot

O35326, Q640L9

Related

ENSMUSP00000131323.2, ENSMUST00000094693.11

Conserved Domains (2) summary

cd12595
Location:5 → 74

RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

cd12765
Location:99 → 179

RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
NM_001079695.3 → NP_001073163.1 serine/arginine-rich splicing factor 5 isoform 1

See identical proteins and their annotated locations for NP_001073163.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) encodes isoform 1. Variants 1, 2 and 3 encode the same isoform.

Source sequence(s)

AA388848, AK146624, BY143979

Consensus CDS

CCDS36484.1

UniProtKB/Swiss-Prot

O35326, Q640L9

Related

ENSMUSP00000105985.3, ENSMUST00000110356.3

Conserved Domains (2) summary

cd12595
Location:5 → 74

RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

cd12765
Location:99 → 179

RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
NM_001347415.2 → NP_001334344.1 serine/arginine-rich splicing factor 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (4) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1. Variants 4, 5 and 10 encode the same isoform (2).

Source sequence(s)

AA388848, AK007729, BE989777, BY634333

Consensus CDS

CCDS83974.1

UniProtKB/TrEMBL

Q9D8S5

Related

ENSMUSP00000105980.2, ENSMUST00000110351.8

Conserved Domains (2) summary

cd12595
Location:5 → 74

RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

cd12765
Location:99 → 179

RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
NM_001347416.2 → NP_001334345.1 serine/arginine-rich splicing factor 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (5) differs in the 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) has the same N- and C-termini, but is one aa longer than isoform 1. Variants 4, 5 and 10 encode the same isoform (2).

Source sequence(s)

AA388848, AK007729, AK146624, BY634333

Consensus CDS

CCDS83974.1

UniProtKB/TrEMBL

Q9D8S5

Conserved Domains (2) summary

cd12595
Location:5 → 74

RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

cd12765
Location:99 → 179

RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)
NM_001409833.1 → NP_001396762.1 serine/arginine-rich splicing factor 5 isoform 3

Status: VALIDATED

Source sequence(s)

AC125092
NM_001409834.1 → NP_001396763.1 serine/arginine-rich splicing factor 5 isoform 4

Status: VALIDATED

Source sequence(s)

AC125092
NM_001409835.1 → NP_001396764.1 serine/arginine-rich splicing factor 5 isoform 5

Status: VALIDATED

Description

Transcript Variant: Variants 8 and 9 encode the same isoform (5).

Source sequence(s)

AC125092
NM_001409836.1 → NP_001396765.1 serine/arginine-rich splicing factor 5 isoform 5

Status: VALIDATED

Description

Transcript Variant: Variants 8 and 9 encode the same isoform (5).

Source sequence(s)

AC125092
NM_001409837.1 → NP_001396766.1 serine/arginine-rich splicing factor 5 isoform 2

Status: VALIDATED

Description

Transcript Variant: Variants 4, 5 and 10 encode the same isoform (2).

Source sequence(s)

AC125092

UniProtKB/TrEMBL

Q9D8S5
NM_009159.4 → NP_033185.2 serine/arginine-rich splicing factor 5 isoform 1

See identical proteins and their annotated locations for NP_033185.2

Status: VALIDATED

Description

Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same isoform (1).

Source sequence(s)

AA388848, AK146624

Consensus CDS

CCDS36484.1

UniProtKB/Swiss-Prot

O35326, Q640L9

Related

ENSMUSP00000105981.4, ENSMUST00000110352.10

Conserved Domains (2) summary

cd12595
Location:5 → 74

RRM1_SRSF5; RNA recognition motif 1 (RRM1) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)

cd12765
Location:99 → 179

RRM2_SRSF5; RNA recognition motif 2 (RRM2) found in vertebrate serine/arginine-rich splicing factor 5 (SRSF5)