Sstr2 somatostatin receptor 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Sstr2provided by MGI
Official Full Name: somatostatin receptor 2provided by MGI
Primary source: MGI:MGI:98328
See related: Ensembl:ENSMUSG00000047904 AllianceGenome:MGI:98328
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: SS2R; sst2; SRIF-1; SSTR-2; Smstr2; Smstr-2
Summary: The protein encoded by this gene is a receptor for somatostatin, which acts at many sites to inhibit the release of several hormones and other secretory proteins. The encoded protein is a member of the superfamily of receptors having seven transmembrane segments and is involved in many processes, including adenylyl cyclase inhibition, phosphotyrosine phosphatase stimulation, and inhibition of calcium entry and cell growth. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]
Expression: Biased expression in whole brain E14.5 (RPKM 13.8), CNS E14 (RPKM 13.2) and 13 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 E2; 11 79.05 cM

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (113510153..113516854)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (113619327..113626028)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Sstr2 Defines the Cone Differentiation-Competent Late-Stage Retinal Progenitor Cells in the Developing Mouse Retina.
Title: Sstr2 Defines the Cone Differentiation-Competent Late-Stage Retinal Progenitor Cells in the Developing Mouse Retina.
sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-beta1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
Title: sST2: A Bridge Between Sirt1/p53/p21 Signal-Induced Senescence and TGF-β1/Smad2/3 Regulation of Cardiac Fibrosis in Mouse Viral Myocarditis.
Changes in dorsal root ganglion CGRP expression in mouse pinch nerve injury model: Modulation by Somatostatin type-2 receptor.
Title: Changes in dorsal root ganglion CGRP expression in mouse pinch nerve injury model: Modulation by Somatostatin type-2 receptor.
Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
Title: Antagonizing somatostatin receptor subtype 2 and 5 reduces blood glucose in a gut- and GLP-1R-dependent manner.
A potential role for somatostatin signaling in regulating retinal neurogenesis.
Title: A potential role for somatostatin signaling in regulating retinal neurogenesis.
Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.
Title: Somatostatin Type 2 Receptor Antibody Enhances Mechanical Hyperalgesia in the Dorsal Root Ganglion Neurons after Sciatic Nerve-pinch Injury: Evidence of Behavioral Studies and Bax Protein Expression.
SSTR2 is primarily expressed and colocalized intracellularly. Activation of SSTR2, 5 and CB1R protected huntingtin-mutant knock-in striatal neurons from quinolinic-acid-induced toxicity. Co-activation of SSTRs and CB1R resulted in loss of protective effects, delayed ERK1/2 phosphorylation and altered receptor complex composition.
Title: Somatostatin and cannabinoid receptors crosstalk in protection of huntingtin knock-in striatal neuronal cells in response to quinolinic acid.
Unpredictable chronic mild stress (UCMS) caused neuroendocrine changes, physical deteriorations, increased anxiety- and depressive-like behaviors and working memory impairments. sst2KO mice displayed behavioral alterations which were similar to stressed WT and exhibited exacerbated changes following UCMS exposure. The evaluations performed in the older mice showed significant long-term effects of UCMS exposure.
Title: sst(2)-receptor gene deletion exacerbates chronic stress-induced deficits: Consequences for emotional and cognitive ageing.
SSTR2 is mainly expressed in distal tubules and collecting ducts in murine kidneys, and the expression of SSTR2 decreases during cyst growth in two polycystic kidney disease mouse models
Title: The expression of somatostatin receptor 2 decreases during cyst growth in mice with polycystic kidney disease.
Both hippocampal sst2 and sst4 receptors selectively inhibit stress-induced HPA axis activation but mediate anxiolytic and antidepressive effects through distinct mechanisms.
Title: Roles of Hippocampal Somatostatin Receptor Subtypes in Stress Response and Emotionality.

Submit: New GeneRIF Correction See all GeneRIFs (54)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Markers

Smstr2 (e-PCR), detects polymorphism
- UniSTS:144455

Smstr2 (e-PCR), detects polymorphism
- UniSTS:144456

NoName (e-PCR)
- UniSTS:494160

Sstr2 (e-PCR), detects polymorphism
- UniSTS:531383

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables PDZ domain binding	ISO Inferred from Sequence Orthology more info
enables neuropeptide binding	IBA Inferred from Biological aspect of Ancestor more info
enables somatostatin receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables somatostatin receptor activity	IDA Inferred from Direct Assay more info	PubMed
enables somatostatin receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables somatostatin receptor activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to estradiol stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to glucocorticoid stimulus	IBA Inferred from Biological aspect of Ancestor more info
involved_in neuropeptide signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuropeptide signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in peristalsis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatostatin signaling pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: somatostatin receptor type 2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001042606.3 → NP_001036071.1 somatostatin receptor type 2 isoform A

See identical proteins and their annotated locations for NP_001036071.1

Status: VALIDATED

Source sequence(s)

AL603705

Consensus CDS

CCDS59571.1

UniProtKB/Swiss-Prot

P30875, P30934, Q91Y73

Related

ENSMUSP00000138101.2, ENSMUST00000146390.3

Conserved Domains (1) summary

cd15971
Location:44 → 323

7tmA_SSTR2; somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors
NM_009217.5 → NP_033243.2 somatostatin receptor type 2 isoform B

See identical proteins and their annotated locations for NP_033243.2

Status: VALIDATED

Source sequence(s)

AL603705

Consensus CDS

CCDS25598.1

UniProtKB/Swiss-Prot

P30875

Related

ENSMUSP00000102241.2, ENSMUST00000106630.2

Conserved Domains (1) summary

cd15971
Location:44 → 323

7tmA_SSTR2; somatostatin receptor type 2, member of the class A family of seven-transmembrane G protein-coupled receptors