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    Zfp605 zinc finger protein 605 [ Mus musculus (house mouse) ]

    Gene ID: 675812, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Zfp605provided by MGI
    Official Full Name
    zinc finger protein 605provided by MGI
    Primary source
    MGI:MGI:2444933
    See related
    Ensembl:ENSMUSG00000023284 AllianceGenome:MGI:2444933
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A830023I12Rik
    Summary
    Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Orthologous to human ZNF605 (zinc finger protein 605). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in CNS E18 (RPKM 2.5), CNS E14 (RPKM 2.3) and 21 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp605 in Genome Data Viewer
    Location:
    5 F; 5 53.3 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110257898..110279402)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110110028..110131536)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 54335 Neighboring gene STARR-positive B cell enhancer ABC_E4778 Neighboring gene STARR-positive B cell enhancer ABC_E10339 Neighboring gene STARR-positive B cell enhancer ABC_E3597 Neighboring gene phosphatidylinositol-specific phospholipase C, X domain containing 1 Neighboring gene GTP binding protein 6 (putative) Neighboring gene nucleophosmin pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E6362 Neighboring gene STARR-seq mESC enhancer starr_13946 Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene STARR-positive B cell enhancer mm9_chr5:110605377-110605678 Neighboring gene predicted gene 15787 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:110605669-110605852 Neighboring gene golgin A3 Neighboring gene uncharacterized LOC118568795

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Genomic variants in an inbred mouse model predict mania-like behaviors. Saul MC, et al. PLoS One, 2018. PMID 29768498, Free PMC Article
    2. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    3. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Spontaneous (1)  1 citation

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC7438

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 605

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001163996.1 → NP_001157468.1  zinc finger protein 605

      See identical proteins and their annotated locations for NP_001157468.1

      Status: VALIDATED

      Source sequence(s)
      AC166747, AK043719
      Consensus CDS
      CCDS51605.1
      UniProtKB/TrEMBL
      E9QAH2, F6VFU8
      Related
      ENSMUSP00000108147.2, ENSMUST00000112528.8
      Conserved Domains (3) summary
      smart00349
      Location:7 → 62
      KRAB; krueppel associated box
      COG5048
      Location:331 → 693
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110257898..110279402
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006535186.5 → XP_006535249.1  zinc finger protein 605 isoform X1

      See identical proteins and their annotated locations for XP_006535249.1

      UniProtKB/TrEMBL
      E9QAH2, F6VFU8
      Conserved Domains (3) summary
      smart00349
      Location:7 → 62
      KRAB; krueppel associated box
      COG5048
      Location:331 → 693
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]

    2. XM_006535188.4 → XP_006535251.1  zinc finger protein 605 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:266 → 628
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]

    3. XM_036165438.1 → XP_036021331.1  zinc finger protein 605 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:266 → 628
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]

    4. XM_006535187.5 → XP_006535250.1  zinc finger protein 605 isoform X1

      See identical proteins and their annotated locations for XP_006535250.1

      UniProtKB/TrEMBL
      E9QAH2, F6VFU8
      Conserved Domains (3) summary
      smart00349
      Location:7 → 62
      KRAB; krueppel associated box
      COG5048
      Location:331 → 693
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:473 → 493
      ZF_C2H2; C2H2 Zn finger [structural motif]

    5. XM_036165437.1 → XP_036021330.1  zinc finger protein 605 isoform X2

      Conserved Domains (2) summary
      COG5048
      Location:266 → 628
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:408 → 428
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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