Eef1e1 eukaryotic translation elongation factor 1 epsilon 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Eef1e1provided by MGI
Official Full Name: eukaryotic translation elongation factor 1 epsilon 1provided by MGI
Primary source: MGI:MGI:1913393
See related: Ensembl:ENSMUSG00000001707 AllianceGenome:MGI:1913393
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AIMP3; 1110003A02Rik
Summary: Involved in negative regulation of cell population proliferation and positive regulation of apoptotic process. Acts upstream of or within cellular response to leukemia inhibitory factor; positive regulation of DNA damage response, signal transduction by p53 class mediator; and positive regulation of apoptotic signaling pathway. Located in cytoplasm and nucleus. Part of aminoacyl-tRNA synthetase multienzyme complex. Is expressed in several structures, including central nervous system and retina. Orthologous to human EEF1E1 (eukaryotic translation elongation factor 1 epsilon 1). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in CNS E18 (RPKM 24.2), liver E14 (RPKM 23.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 13 A3.3; 13 18.38 cM

Exon count:: 4

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	13	NC_000079.7 (38829667..38843004, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	13	NC_000079.6 (38645691..38659028, complement)

Chromosome 13 - NC_000079.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

high-affinity T cells sustained IL-2R expression longer and expressed two novel Th cell differentiation regulators, Eef1e1 and Gbp2, to a higher level than low-affinity T cells.
Title: TCR Affinity Biases Th Cell Differentiation by Regulating CD25, Eef1e1, and Gbp2.
gamma-H2AX removal was delayed, and homologous DNA repair activity was significantly reduced. Reduction of RPA foci formation and subsequent Rad51 foci formation probably underlie the significant reduction in homologous recombination activity in the absence of AIMP3. Together, our data demonstrate that AIMP3 plays a role in genome stability through the DNA repair process
Title: AIMP3 Deletion Induces Acute Radiation Syndrome-like Phenotype in Mice.
AIMP3 is a specific regulator of mature lamin A and imply that enhanced expression of AIMP3 might be a factor driving cellular and/or organismal aging [AIMP3]
Title: Downregulation of lamin A by tumor suppressor AIMP3/p18 leads to a progeroid phenotype in mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Gene trapped (2) 1 citation
Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to leukemia inhibitory factor	IEP Inferred from Expression Pattern more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within positive regulation of DNA damage response, signal transduction by p53 class mediator	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of apoptotic signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cellular senescence	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within translation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of aminoacyl-tRNA synthetase multienzyme complex	IBA Inferred from Biological aspect of Ancestor more info
part_of aminoacyl-tRNA synthetase multienzyme complex	IDA Inferred from Direct Assay more info	PubMed
part_of aminoacyl-tRNA synthetase multienzyme complex	ISO Inferred from Sequence Orthology more info
part_of aminoacyl-tRNA synthetase multienzyme complex	NAS Non-traceable Author Statement more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: eukaryotic translation elongation factor 1 epsilon-1

Names: elongation factor p18; multisynthase complex auxiliary component p18; multisynthetase complex auxiliary component p18

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025380.2 → NP_079656.1 eukaryotic translation elongation factor 1 epsilon-1

See identical proteins and their annotated locations for NP_079656.1

Status: VALIDATED

Source sequence(s)

AK003335, AK009889, BY197082

Consensus CDS

CCDS26465.1

UniProtKB/Swiss-Prot

Q9D1M4

Related

ENSMUSP00000001757.8, ENSMUST00000001757.9

Conserved Domains (1) summary

cd10305
Location:65 → 165

GST_C_AIMP3; Glutathione S-transferase C-terminal-like, alpha helical domain of Aminoacyl tRNA synthetase complex-Interacting Multifunctional Protein 3