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    Golga3 golgin A3 [ Mus musculus (house mouse) ]

    Gene ID: 269682, updated on 12-May-2024

    Summary

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    Official Symbol
    Golga3provided by MGI
    Official Full Name
    golgin A3provided by MGI
    Primary source
    MGI:MGI:96958
    See related
    Ensembl:ENSMUSG00000029502 AllianceGenome:MGI:96958
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Mea2; Mea-2; repro27; G1-499-14; 5330413L04; Mea2/Golga3; 5430416E01Rik
    Summary
    Predicted to act upstream of or within cell differentiation and spermatogenesis. Located in Golgi membrane and endoplasmic reticulum-Golgi intermediate compartment. Is expressed in several structures, including cardiovascular system; endocrine gland; genitourinary system; gut; and nervous system. Orthologous to human GOLGA3 (golgin A3). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.9), bladder adult (RPKM 5.9) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Golga3 in Genome Data Viewer
    Location:
    5 F; 5 53.36 cM
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (110324723..110374336)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (110176857..110226470)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene zinc finger protein 605 Neighboring gene STARR-positive B cell enhancer ABC_E6362 Neighboring gene nucleophosmin pseudogene Neighboring gene STARR-seq mESC enhancer starr_13946 Neighboring gene checkpoint with forkhead and ring finger domains Neighboring gene STARR-positive B cell enhancer mm9_chr5:110605377-110605678 Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:110605669-110605852 Neighboring gene predicted gene 15787 Neighboring gene uncharacterized LOC118568795 Neighboring gene STARR-seq mESC enhancer starr_13947 Neighboring gene ankyrin repeat and LEM domain containing 2 Neighboring gene STARR-seq mESC enhancer starr_13949 Neighboring gene phosphoglycerate mutase family member 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis. Xu C, et al. PeerJ, 2023. PMID 37090114, Free PMC Article
    2. New point mutation in Golga3 causes multiple defects in spermatogenesis. Bentson LF, et al. Andrology, 2013 May. PMID 23495255, Free PMC Article
    3. Mea2/Golga3 gene is disrupted in a line of transgenic mice with a reciprocal translocation between Chromosomes 5 and 19 and is responsible for a defective spermatogenesis in homozygotes. Matsukuma S, et al. Mamm Genome, 1999 Jan. PMID 9892724
    4. Cloning and molecular characterization of cDNA encoding a mouse male-enhanced antigen-2 (Mea-2): a putative family of the Golgi autoantigen. Kondo M, et al. DNA Seq, 1997. PMID 9063644
    5. Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes. Williams D, et al. Mol Biol Cell, 2006 Dec. PMID 17050738, Free PMC Article

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis.
      Title: Mutation of S461, in the GOLGA3 phosphorylation site, does not affect mouse spermatogenesis.
    2. Golga3(repro27) mice lack GOLGA3 protein and thus provide an in vivo tool to aid in deciphering the role of GOLGA3 in Golgi complex positioning, cargo trafficking and apoptosis signalling in male germ cells
      Title: New point mutation in Golga3 causes multiple defects in spermatogenesis.
    3. These data demonstrate that golgin-160 plays an important role in directing insulin-regulated trafficking proteins toward the insulin-responsive compartment in adipocytes.
      Title: Golgin-160 is required for the Golgi membrane sorting of the insulin-responsive glucose transporter GLUT4 in adipocytes.
    4. a truncated form of Mea2 devoid of the N-terminal region, DeltaMea2, was expressed
      Title: Co-localization of Trax and Mea2 in Golgi complex of pachytene spermatocytes in the mouse.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (2) 
    • Targeted (2) 
    • Transgenic (1)  1 citation

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in Golgi membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in endoplasmic reticulum-Golgi intermediate compartment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    golgin subfamily A member 3
    Names
    golgi autoantigen, golgin subfamily a, 3
    golgin-160
    male-enhanced antigen 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347389.2 → NP_001334318.1  golgin subfamily A member 3 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC118260
      Consensus CDS
      CCDS84928.1
      UniProtKB/Swiss-Prot
      P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
      UniProtKB/TrEMBL
      E9QP99
      Related
      ENSMUSP00000031477.9, ENSMUST00000031477.9
      Conserved Domains (2) summary
      COG1196
      Location:622 → 1357
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:431 → 771
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. NM_008146.4 → NP_032172.3  golgin subfamily A member 3 isoform 2

      See identical proteins and their annotated locations for NP_032172.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1.
      Source sequence(s)
      AC118260, AW490576, BC053002
      Consensus CDS
      CCDS39209.1
      UniProtKB/Swiss-Prot
      P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
      UniProtKB/TrEMBL
      A0A0R4J1H6
      Related
      ENSMUSP00000108131.2, ENSMUST00000112512.8
      Conserved Domains (2) summary
      COG1196
      Location:582 → 1317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:353 → 724
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      110324723..110374336
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534961.5 → XP_006535024.1  golgin subfamily A member 3 isoform X1

      See identical proteins and their annotated locations for XP_006535024.1

      UniProtKB/Swiss-Prot
      P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
      UniProtKB/TrEMBL
      E9QP99
      Conserved Domains (2) summary
      COG1196
      Location:622 → 1357
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:431 → 771
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type

    2. XM_030254534.2 → XP_030110394.1  golgin subfamily A member 3 isoform X2

      UniProtKB/Swiss-Prot
      P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
      UniProtKB/TrEMBL
      A0A0R4J1H6
      Conserved Domains (2) summary
      COG1196
      Location:582 → 1317
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02168
      Location:353 → 724
      SMC_prok_B; chromosome segregation protein SMC, common bacterial type

    3. XM_006534962.4 → XP_006535025.1  golgin subfamily A member 3 isoform X1

      See identical proteins and their annotated locations for XP_006535025.1

      UniProtKB/Swiss-Prot
      P55937, Q80VF5, Q8CCK4, Q9QYT2, Q9QYT3
      UniProtKB/TrEMBL
      E9QP99
      Conserved Domains (2) summary
      COG1196
      Location:622 → 1357
      Smc; Chromosome segregation ATPase [Cell cycle control, cell division, chromosome partitioning]
      TIGR02169
      Location:431 → 771
      SMC_prok_A; chromosome segregation protein SMC, primarily archaeal type
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P55937.3 GenPept UniProtKB/Swiss-Prot:P55937

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