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    Cog1 component of oligomeric golgi complex 1 [ Mus musculus (house mouse) ]

    Gene ID: 16834, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cog1provided by MGI
    Official Full Name
    component of oligomeric golgi complex 1provided by MGI
    Primary source
    MGI:MGI:1333873
    See related
    Ensembl:ENSMUSG00000018661 AllianceGenome:MGI:1333873
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ldlb; mKIAA1381; 6030445I15
    Summary
    Predicted to be involved in intra-Golgi vesicle-mediated transport. Predicted to act upstream of or within protein transport. Predicted to be located in membrane. Predicted to be part of Golgi transport complex. Predicted to be active in Golgi apparatus. Is expressed in cerebral cortex and cerebral cortex marginal layer. Human ortholog(s) of this gene implicated in congenital disorder of glycosylation type IIg. Orthologous to human COG1 (component of oligomeric golgi complex 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon adult (RPKM 24.9), testis adult (RPKM 20.1) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cog1 in Genome Data Viewer
    Location:
    11 E2; 11 79.1 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (113540004..113560157)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (113649178..113669331)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene solute carrier family 39 (metal ion transporter), member 11 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113331428-113331537 Neighboring gene predicted gene, 51928 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113427091-113427274 Neighboring gene STARR-seq mESC enhancer starr_31093 Neighboring gene STARR-seq mESC enhancer starr_31094 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113473355-113473542 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113473648-113473949 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113475868-113476055 Neighboring gene STARR-positive B cell enhancer mm9_chr11:113478982-113479282 Neighboring gene STARR-positive B cell enhancer ABC_E4012 Neighboring gene somatostatin receptor 2 Neighboring gene STARR-positive B cell enhancer ABC_E4013 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:113545452-113545561 Neighboring gene STARR-seq mESC enhancer starr_31100 Neighboring gene STARR-seq mESC enhancer starr_31103 Neighboring gene VCP nuclear cofactor family member 1 Neighboring gene mitochondrial nucleoid associated protein 1 Neighboring gene cleavage and polyadenylation specific factor 4-like Neighboring gene STARR-positive B cell enhancer ABC_E8469 Neighboring gene CDC42 effector protein 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A null mutation in murine CD36 reveals an important role in fatty acid and lipoprotein metabolism. Febbraio M, et al. J Biol Chem, 1999 Jul 2. PMID 10383407
    2. Expression cloning of LDLB, a gene essential for normal Golgi function and assembly of the ldlCp complex. Chatterton JE, et al. Proc Natl Acad Sci U S A, 1999 Feb 2. PMID 9927668, Free PMC Article
    3. Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function. Zhang T, et al. Sci Rep, 2017 Apr 5. PMID 28378742, Free PMC Article
    4. BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING). Motani K, et al. J Biol Chem, 2020 Aug 7. PMID 32554809, Free PMC Article
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA1381

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in Golgi organization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in glycosylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in intra-Golgi vesicle-mediated transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within protein transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retrograde transport, vesicle recycling within Golgi ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in Golgi apparatus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Golgi transport complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    conserved oligomeric Golgi complex subunit 1
    Names
    COG complex subunit 1
    low density lipoprotein B
    low density lipoprotein receptor defect B-complementing protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_013581.3 → NP_038609.3  conserved oligomeric Golgi complex subunit 1

      See identical proteins and their annotated locations for NP_038609.3

      Status: VALIDATED

      Source sequence(s)
      BC063056, BY721599
      Consensus CDS
      CCDS25599.1
      UniProtKB/Swiss-Prot
      Q6P567, Q9Z160
      UniProtKB/TrEMBL
      Q3TR89, Q3TWY6
      Related
      ENSMUSP00000018805.9, ENSMUST00000018805.15
      Conserved Domains (1) summary
      pfam08700
      Location:17 → 91
      Vps51; Vps51/Vps67

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      113540004..113560157
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006532343.4 → XP_006532406.1  conserved oligomeric Golgi complex subunit 1 isoform X1

      UniProtKB/TrEMBL
      Q5DTY3
      Conserved Domains (1) summary
      pfam08700
      Location:39 → 114
      Vps51; Vps51/Vps67

    2. XM_006532346.2 → XP_006532409.1  conserved oligomeric Golgi complex subunit 1 isoform X3

      UniProtKB/TrEMBL
      Q3U7X8

    3. XM_006532344.2 → XP_006532407.1  conserved oligomeric Golgi complex subunit 1 isoform X2

      See identical proteins and their annotated locations for XP_006532407.1

      UniProtKB/TrEMBL
      Q5DTY3
      Conserved Domains (1) summary
      pfam08700
      Location:39 → 114
      Vps51; Vps51/Vps67

    4. XM_006532345.2 → XP_006532408.1  conserved oligomeric Golgi complex subunit 1 isoform X2

      See identical proteins and their annotated locations for XP_006532408.1

      UniProtKB/TrEMBL
      Q5DTY3
      Conserved Domains (1) summary
      pfam08700
      Location:39 → 114
      Vps51; Vps51/Vps67

    RNA

    1. XR_388357.2 RNA Sequence

    2. XR_388356.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9Z160.3 GenPept UniProtKB/Swiss-Prot:Q9Z160

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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