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    Sec14l1 SEC14-like lipid binding 1 [ Mus musculus (house mouse) ]

    Gene ID: 74136, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Sec14l1provided by MGI
    Official Full Name
    SEC14-like lipid binding 1provided by MGI
    Primary source
    MGI:MGI:1921386
    See related
    Ensembl:ENSMUSG00000020823 AllianceGenome:MGI:1921386
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Naa-35; 1200017E04Rik; 2810012L19Rik
    Summary
    Predicted to enable RIG-I binding activity. Predicted to be involved in choline transport and negative regulation of RIG-I signaling pathway. Predicted to act upstream of or within innate immune response and negative regulation of signal transduction. Predicted to be located in cytosol and nucleoplasm. Predicted to colocalize with Golgi apparatus. Is expressed in cerebral cortex marginal layer and lung. Orthologous to human SEC14L1 (SEC14 like lipid binding 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 39.9), lung adult (RPKM 31.2) and 27 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sec14l1 in Genome Data Viewer
    Location:
    11 E2; 11 81.99 cM
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (117005994..117050094)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (117115168..117159268)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_31237 Neighboring gene STARR-positive B cell enhancer ABC_E5302 Neighboring gene microRNA 6516 Neighboring gene small nucleolar RNA host gene 20 Neighboring gene predicted gene 11730 Neighboring gene STARR-positive B cell enhancer ABC_E9848 Neighboring gene 60S ribosomal protein L12 pseudogene Neighboring gene STARR-seq mESC enhancer starr_31240 Neighboring gene septin 9 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117127061-117127170 Neighboring gene predicted gene, 39478 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117153788-117154073 Neighboring gene STARR-seq mESC enhancer starr_31245 Neighboring gene STARR-positive B cell enhancer ABC_E4019 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117181442-117181643 Neighboring gene STARR-positive B cell enhancer ABC_E8473 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:117187354-117187555 Neighboring gene predicted gene, 34065

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs. Kostenko EV, et al. J Biol Chem, 2005 Jan 28. PMID 15531584
    2. A novel view of the transcriptome revealed from gene trapping in mouse embryonic stem cells. Roma G, et al. Genome Res, 2007 Jul. PMID 17540781, Free PMC Article
    3. Prediction of the coding sequences of mouse homologues of KIAA gene: IV. The complete nucleotide sequences of 500 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries. Okazaki N, et al. DNA Res, 2004 Jun 30. PMID 15368895
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. the Sec14 domain regulates Dbs transformation through at least two distinct mechanisms, neither of which appears to directly influence the in vivo exchange activity of the protein
      Title: The Sec14 homology domain regulates the cellular distribution and transforming activity of the Rho-specific guanine nucleotide exchange factor Dbs.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RIG-I binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RIG-I binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein sequestering activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in choline transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within immune system process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of RIG-I signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of signal transduction IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    colocalizes_with Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    SEC14-like protein 1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001166506.2 → NP_001159978.1  SEC14-like protein 1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AK047396, AL627205, BB646963, BC086620
      Consensus CDS
      CCDS48989.1
      UniProtKB/Swiss-Prot
      A2A9B9, A8Y5H7, Q6A071, Q99J07, Q9DBQ0
      Related
      ENSMUSP00000087916.6, ENSMUST00000090433.6
      Conserved Domains (3) summary
      smart01100
      Location:256 → 301
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:326 → 490
      CRAL_TRIO; CRAL/TRIO domain
      pfam04707
      Location:17 → 173
      PRELI; PRELI-like family

    2. NM_001166507.2 → NP_001159979.1  SEC14-like protein 1 isoform 3

      See identical proteins and their annotated locations for NP_001159979.1

      Status: VALIDATED

      Source sequence(s)
      AK047396, AL627205, BB646963, BC086620
      Consensus CDS
      CCDS48988.1
      UniProtKB/Swiss-Prot
      A8Y5H7
      Related
      ENSMUSP00000099315.4, ENSMUST00000103026.10
      Conserved Domains (3) summary
      smart01100
      Location:256 → 301
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:326 → 490
      CRAL_TRIO; CRAL/TRIO domain
      pfam04707
      Location:17 → 173
      PRELI; PRELI-like family

    3. NM_001363165.1 → NP_001350094.1  SEC14-like protein 1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL627205
      Conserved Domains (3) summary
      smart01100
      Location:222 → 267
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:292 → 456
      CRAL_TRIO; CRAL/TRIO domain
      pfam04707
      Location:1 → 139
      PRELI; PRELI-like family

    4. NM_028777.4 → NP_083053.2  SEC14-like protein 1 isoform 1

      See identical proteins and their annotated locations for NP_083053.2

      Status: VALIDATED

      Source sequence(s)
      AK004818, AK047396, AL627205, BB646963, BC086620
      Consensus CDS
      CCDS25683.1
      UniProtKB/Swiss-Prot
      A8Y5H7
      Related
      ENSMUSP00000021177.9, ENSMUST00000021177.15
      Conserved Domains (3) summary
      smart01100
      Location:256 → 301
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:326 → 490
      CRAL_TRIO; CRAL/TRIO domain
      pfam04707
      Location:17 → 173
      PRELI; PRELI-like family

    RNA

    1. NR_029459.2 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AK047396, AL627205, BB646963, CJ066501
      Related
      ENSMUST00000146585.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      117005994..117050094
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006534352.2 → XP_006534415.1  SEC14-like protein 1 isoform X1

      Conserved Domains (3) summary
      smart01100
      Location:222 → 267
      CRAL_TRIO_N; CRAL/TRIO, N-terminal domain
      pfam00650
      Location:292 → 456
      CRAL_TRIO; CRAL/TRIO domain
      pfam04707
      Location:1 → 139
      PRELI; PRELI-like family
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    A8Y5H7.1 GenPept UniProtKB/Swiss-Prot:A8Y5H7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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