Tnnc2 troponin C2, fast [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Tnnc2provided by MGI
Official Full Name: troponin C2, fastprovided by MGI
Primary source: MGI:MGI:98780
See related: Ensembl:ENSMUSG00000017300 AllianceGenome:MGI:98780
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tncs
Summary: Predicted to enable actin filament binding activity; calcium ion binding activity; and calcium-dependent protein binding activity. Predicted to contribute to actin binding activity. Predicted to be involved in regulation of muscle contraction and skeletal muscle contraction. Predicted to be part of troponin complex. Is expressed in several structures, including alimentary system; limb segment; skeletal musculature; urinary system; and urogenital ridge. Orthologous to human TNNC2 (troponin C2, fast skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in mammary gland adult (RPKM 240.7), limb E14.5 (RPKM 66.2) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 H3; 2 85.27 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (164619081..164621654, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (164777161..164779734, complement)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Data found that fTnC normally associated with fast twitch skeletal muscle were present at significant levels in the thoracic aorta, and that fTnC transcripts were expressed in the smooth muscle layer of mouse blood vessels of all sizes.
Title: Expression of the fast twitch troponin complex, fTnT, fTnI and fTnC, in vascular smooth muscle.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Tncs (e-PCR), detects polymorphism
- UniSTS:238172

Tnnc2 (e-PCR), detects polymorphism
- UniSTS:525951

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
contributes_to actin binding	ISO Inferred from Sequence Orthology more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in regulation of muscle contraction	ISO Inferred from Sequence Orthology more info
involved_in skeletal muscle contraction	IBA Inferred from Biological aspect of Ancestor more info
involved_in skeletal muscle contraction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of troponin complex	IBA Inferred from Biological aspect of Ancestor more info
part_of troponin complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: troponin C, skeletal muscle

Names: STNC; troponin C, fast skeletal

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.