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    Cdc5l cell division cycle 5-like [ Mus musculus (house mouse) ]

    Gene ID: 71702, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cdc5lprovided by MGI
    Official Full Name
    cell division cycle 5-likeprovided by MGI
    Primary source
    MGI:MGI:1918952
    See related
    Ensembl:ENSMUSG00000023932 AllianceGenome:MGI:1918952
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    PCDC5RP; 1200002I02Rik
    Summary
    Predicted to enable several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; enzyme binding activity; and protein domain specific binding activity. Predicted to be involved in several processes, including DNA damage checkpoint signaling; cellular response to nerve growth factor stimulus; and cellular response to wortmannin. Predicted to act upstream of or within DNA repair; RNA splicing; and mRNA processing. Predicted to be located in nuclear speck and perinuclear region of cytoplasm. Predicted to be part of DNA replication factor A complex; Prp19 complex; and U2-type catalytic step 2 spliceosome. Is expressed in several structures, including branchial arch; early conceptus; genitourinary system; limb; and maxillary process. Human ortholog(s) of this gene implicated in osteosarcoma. Orthologous to human CDC5L (cell division cycle 5 like). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 14.3), CNS E14 (RPKM 10.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cdc5l in Genome Data Viewer
    Location:
    17 B3; 17 22.36 cM
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (45702809..45744633, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (45391887..45433707, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41582 Neighboring gene predicted gene, 35204 Neighboring gene STARR-positive B cell enhancer ABC_E8677 Neighboring gene RIKEN cDNA B230354K17 gene Neighboring gene STARR-positive B cell enhancer ABC_E5612 Neighboring gene STARR-seq mESC enhancer starr_42621 Neighboring gene spermatogenesis associated, serine-rich 1 Neighboring gene ribosomal protein L21 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Evidence that Myb-related CDC5 proteins are required for pre-mRNA splicing. Burns CG, et al. Proc Natl Acad Sci U S A, 1999 Nov 23. PMID 10570151, Free PMC Article
    2. CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1. Jokoji G, et al. J Biol Chem, 2021 Aug. PMID 34298017, Free PMC Article
    3. BCAS2 is involved in alternative splicing and mouse oocyte development. Zhang J, et al. FASEB J, 2022 Feb. PMID 34972250
    4. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31. Ganesh K, et al. J Biol Chem, 2011 May 13. PMID 21385873, Free PMC Article
    5. LIM-domain transcription complexes interact with ring-finger ubiquitin ligases and thereby impact islet β-cell function. Wade AK, et al. J Biol Chem, 2019 Aug 2. PMID 31186351, Free PMC Article

    See all (43) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31
      Title: CTNNBL1 is a novel nuclear localization sequence-binding protein that recognizes RNA-splicing factors CDC5L and Prp31.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (5) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables WD40-repeat domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables leucine zipper domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 1 binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription corepressor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within DNA damage response IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within DNA repair IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cellular response to nerve growth factor stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to wortmannin ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in mRNA splicing, via spliceosome NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA replication factor A complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Prp19 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Prp19 complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of U2-type catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of catalytic step 2 spliceosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nuclear speck ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of protein-DNA complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of spliceosomal complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of spliceosomal complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    cell division cycle 5-like protein
    Names
    cdc5-like protein
    cell division cycle 5-related protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_152810.2 → NP_690023.1  cell division cycle 5-like protein

      See identical proteins and their annotated locations for NP_690023.1

      Status: PROVISIONAL

      Source sequence(s)
      AC163677, AC169676
      Consensus CDS
      CCDS37627.1
      UniProtKB/Swiss-Prot
      Q6A068, Q8K1J9
      UniProtKB/TrEMBL
      Q3UCF2
      Related
      ENSMUSP00000024727.9, ENSMUST00000024727.10
      Conserved Domains (4) summary
      smart00717
      Location:8 → 56
      SANT; SANT SWI3, ADA2, N-CoR and TFIIIB'' DNA-binding domains
      cd11659
      Location:56 → 106
      SANT_CDC5_II; SANT/myb-like DNA-binding domain of Cell Division Cycle 5-Like Protein repeat II
      pfam11831
      Location:404 → 655
      Myb_Cef; pre-mRNA splicing factor component
      pfam13921
      Location:11 → 71
      Myb_DNA-bind_6; Myb-like DNA-binding domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      45702809..45744633 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004939578.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6A068.2 GenPept UniProtKB/Swiss-Prot:Q6A068

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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