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    Cgref1 cell growth regulator with EF hand domain 1 [ Mus musculus (house mouse) ]

    Gene ID: 68567, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Cgref1provided by MGI
    Official Full Name
    cell growth regulator with EF hand domain 1provided by MGI
    Primary source
    MGI:MGI:1915817
    See related
    Ensembl:ENSMUSG00000029161 AllianceGenome:MGI:1915817
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cgr11; 1110004G24Rik
    Summary
    Predicted to enable calcium ion binding activity. Predicted to be involved in negative regulation of cell growth. Predicted to act upstream of or within cell adhesion and regulation of cell cycle. Predicted to be located in extracellular region. Is expressed in several structures, including bone; forelimb; heart ventricle; nervous system; and urinary system. Orthologous to human CGREF1 (cell growth regulator with EF-hand domain 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in duodenum adult (RPKM 402.2), kidney adult (RPKM 154.0) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cgref1 in Genome Data Viewer
    Location:
    5 B1; 5 16.9 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 5 NC_000071.7 (31090487..31102771, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 5 NC_000071.6 (30933143..30945480, complement)

    Chromosome 5 - NC_000071.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr5:31218364-31218473 Neighboring gene elastin microfibril interfacer 1 Neighboring gene STARR-positive B cell enhancer ABC_E4749 Neighboring gene ketohexokinase Neighboring gene STARR-positive B cell enhancer ABC_E1679 Neighboring gene abhydrolase domain containing 1 Neighboring gene prolactin regulatory element binding Neighboring gene transcription factor 23

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cgr11 encodes a secretory protein involved in cell adhesion. Devnath S, et al. Eur J Cell Biol, 2009 Sep. PMID 19473726
    2. Activated Braf induces esophageal dilation and gastric epithelial hyperplasia in mice. Inoue SI, et al. Hum Mol Genet, 2017 Dec 1. PMID 28973166
    3. A collection of cDNAs enriched in upper cortical layers of the embryonic mouse brain. García-Frigola C, et al. Brain Res Mol Brain Res, 2004 Mar 30. PMID 15010206
    4. Detection of novel skeletogenesis target genes by comprehensive analysis of a Runx2(-/-) mouse model. Hecht J, et al. Gene Expr Patterns, 2007 Jan. PMID 16829211
    5. Assembly, verification, and initial annotation of the NIA mouse 7.4K cDNA clone set. VanBuren V, et al. Genome Res, 2002 Dec. PMID 12466305, Free PMC Article

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of cell growth ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    cell growth regulator with EF hand domain protein 1
    Names
    cell growth regulatory gene 11 protein
    cell growth regulatory with EF-hand domain
    hydrophobestin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001160149.1 → NP_001153621.1  cell growth regulator with EF hand domain protein 1 precursor

      See identical proteins and their annotated locations for NP_001153621.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, lacks a portion of the 5' coding region, and uses a downstream translational start codon, compared to variant 1. The resulting isoform (2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AK003420, BQ043218, CB202031
      UniProtKB/Swiss-Prot
      Q8R1U2, Q9D1K1
      UniProtKB/TrEMBL
      E9QPK1
      Conserved Domains (2) summary
      TIGR00927
      Location:184 → 278
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam13499
      Location:73 → 143
      EF-hand_7; EF-hand domain pair

    2. NM_026770.2 → NP_081046.2  cell growth regulator with EF hand domain protein 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC109606
      Consensus CDS
      CCDS51454.1
      UniProtKB/Swiss-Prot
      Q8R1U2, Q9D1K1
      UniProtKB/TrEMBL
      E9QPK1
      Related
      ENSMUSP00000031051.8, ENSMUST00000031051.9
      Conserved Domains (2) summary
      TIGR00927
      Location:184 → 278
      2A1904; K+-dependent Na+/Ca+ exchanger
      pfam13499
      Location:73 → 143
      EF-hand_7; EF-hand domain pair

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000071.7 Reference GRCm39 C57BL/6J

      Range
      31090487..31102771 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R1U2.1 GenPept UniProtKB/Swiss-Prot:Q8R1U2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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