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    Amt Ammonium transporter [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41841, updated on 10-May-2024

    Summary

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    Official Symbol
    Amtprovided by FlyBase
    Official Full Name
    Ammonium transporterprovided by FlyBase
    Primary source
    FLYBASE:FBgn0038309
    Locus tag
    Dmel_CG6499
    See related
    AllianceGenome:FB:FBgn0038309
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    CG6499; Dmel\CG6499
    Summary
    Predicted to enable ammonium transmembrane transporter activity. Involved in cellular response to ammonium ion and detection of chemical stimulus involved in sensory perception of smell. Predicted to be integral component of plasma membrane. Is expressed in antenna; leg; and wing disc. [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Amt in Genome Data Viewer
    Location:
    88E4-88E5; 3-56 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15247163..15249137, complement)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11072885..11074859, complement)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene telomere fusion Neighboring gene Heat shock protein 70 cognate 4 Neighboring gene uncharacterized protein Neighboring gene eukaryotic translation initiation factor 2 subunit gamma Neighboring gene Suppressor of variegation 3-9

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The taste response to ammonia in Drosophila. Delventhal R, et al. Sci Rep, 2017 Mar 6. PMID 28262698, Free PMC Article
    2. Spermiogenesis and Male Fertility Require the Function of Suppressor of Hairy-Wing in Somatic Cyst Cells of Drosophila. Duan T, et al. Genetics, 2018 Jul. PMID 29739818, Free PMC Article
    3. The Drosophila ATM ortholog, dATM, mediates the response to ionizing radiation and to spontaneous DNA damage during development. Song YH, et al. Curr Biol, 2004 Aug 10. PMID 15296752
    4. Drosophila Hsc70-4 is critical for neurotransmitter exocytosis in vivo. Bronk P, et al. Neuron, 2001 May. PMID 11395008
    5. An ammonium transporter is a non-canonical olfactory receptor for ammonia. Vulpe A, et al. Curr Biol, 2021 Aug 9. PMID 34111404, Free PMC Article

    See all (32) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ammonium transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ammonium transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ammonium transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in ammonium homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in ammonium transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in ammonium transmembrane transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to ammonium ion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in detection of chemical stimulus involved in sensory perception of smell IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ammonium transporter
    Names
    Amt-PB
    CG6499-PB

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15247163..15249137 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001104330.3 → NP_001097800.1  ammonium transporter [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001097800.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      Q9VFA9
      Conserved Domains (1) summary
      cl03012
      Location:30 → 428
      Ammonium_transp; Ammonium Transporter Family
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9VFA9 Q9VFA9

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