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    Hsc70-4 Heat shock protein 70 cognate 4 [ Drosophila melanogaster (fruit fly) ]

    Gene ID: 41840, updated on 10-May-2024

    Summary

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    Official Symbol
    Hsc70-4provided by FlyBase
    Official Full Name
    Heat shock protein 70 cognate 4provided by FlyBase
    Primary source
    FLYBASE:FBgn0266599
    Locus tag
    Dmel_CG4264
    See related
    AllianceGenome:FB:FBgn0266599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Drosophila melanogaster
    Lineage
    Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota; Neoptera; Endopterygota; Diptera; Brachycera; Muscomorpha; Ephydroidea; Drosophilidae; Drosophila; Sophophora
    Also known as
    anon-WO0118547.237; Bap74; BAP74; bs17d06.y1; C7LA75; CG4264; chr3R:11070155..11070315; dhsc70; dHsp70; dHSP70; Dmel\CG4264; E(csp)1545; E(nd)195; Hsc-4; HSC-70; Hsc-70-4; hsc4; Hsc4; HSC4; Hsc4p; hsc70; Hsc70; HSC70; hsc70-4; HSC70-4; Hsc70.4; Hsp-c4; hsp70; Hsp70; HSP70; HSP70cB2; i190; l(3)03550; l(3)j7A4; l(3)L3929; mtHsp 70; Q3KN45_DROME; scd
    Summary
    Enables chaperone binding activity. Involved in several processes, including axon development; late endosomal microautophagy; and positive regulation of small RNA loading onto RISC. Located in cytoplasm and perichromatin fibrils. Part of catalytic step 2 spliceosome and precatalytic spliceosome. Colocalizes with Z disc and mitochondrial inner membrane. Is expressed in several structures, including adult head; adult heart; embryonic/larval neuromuscular junction; and gonad. Human ortholog(s) of this gene implicated in several diseases, including Kawasaki disease; artery disease (multiple); autoimmune disease of musculoskeletal system (multiple); neurodegenerative disease (multiple); and schizophrenia (multiple). Orthologous to several human genes including HSPA8 (heat shock protein family A (Hsp70) member 8). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See Hsc70-4 in Genome Data Viewer
    Location:
    88E4-88E4; 3-56 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    Release 6.54 current Release 6 plus ISO1 MT (GCF_000001215.4) 3R NT_033777.3 (15242687..15246614)
    Release 5.57 previous assembly Release 5 (GCF_000001215.2) 3R NT_033777.2 (11068409..11072336)

    Chromosome 3R - NT_033777.3Genomic Context describing neighboring genes Neighboring gene antisense RNA:CR43471 Neighboring gene uncharacterized protein Neighboring gene telomere fusion Neighboring gene Ammonium transporter Neighboring gene uncharacterized protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Ubiquitin-interacting motifs of ataxin-3 regulate its polyglutamine toxicity through Hsc70-4-dependent aggregation. Johnson SL, et al. Elife, 2020 Sep 21. PMID 32955441, Free PMC Article
    2. In vivo generation of neurotoxic prion protein: role for hsp70 in accumulation of misfolded isoforms. Fernandez-Funez P, et al. PLoS Genet, 2009 Jun. PMID 19503596, Free PMC Article
    3. Sodium dodecyl sulfate-insoluble oligomers are involved in polyglutamine degeneration. Wong SL, et al. FASEB J, 2008 Sep. PMID 18559990
    4. Intramitochondrial localization of the main 70-kDa heat-shock cognate protein in Drosophila cells. Carbajal EM, et al. Exp Cell Res, 1993 Aug. PMID 8344382
    5. Regulation of dopamine release by CASK-β modulates locomotor initiation in Drosophila melanogaster. Slawson JB, et al. Front Behav Neurosci, 2014. PMID 25477794, Free PMC Article

    See all (266) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. molecular chaperone Hsp70 and Hsc70 play an indispensable role during Drosophila eye development.
      Title: Molecular Chaperone Hsp70 and Its Constitutively Active Form Hsc70 Play an Indispensable Role During Eye Development of Drosophila melanogaster.
    2. Post-transcriptional inhibition of Hsc70-4 expression leads to synaptic vesicle cycling defects in multiple models of amyotrophic lateral sclerosis.
      Title: Post-transcriptional Inhibition of Hsc70-4/HSPA8 Expression Leads to Synaptic Vesicle Cycling Defects in Multiple Models of ALS.
    3. Hsc70-4 controls rejuvenation of the synaptic protein pool in a dual way: either by refolding proteins together with Sgt, or by targeting them for degradation by facilitating endosomal microautophagy based on its membrane deforming activity.
      Title: Hsc70-4 Deforms Membranes to Promote Synaptic Protein Turnover by Endosomal Microautophagy.
    4. interference with its endogenous activity accelerated alpha-synuclein toxicity in Drosophila model of Parkinson's disease
      Title: Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by FlyBase

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ATP-dependent protein folding chaperone IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables heat shock protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein folding chaperone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein-folding chaperone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in RISC complex assembly IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in axon guidance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in axonal fasciculation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in cellular response to topologically incorrect protein IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in chaperone cofactor-dependent protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in chaperone-mediated protein folding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in follicle cell of egg chamber development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in late endosomal microautophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in mRNA splicing, via spliceosome IC
    Inferred by Curator
    more info
    		 PubMed 
    involved_in membrane bending IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in nervous system development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in neurotransmitter secretion IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    involved_in protein refolding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vesicle-mediated transport IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of catalytic step 2 spliceosome HDA PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol HDA PubMed 
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus HDA PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of precatalytic spliceosome HDA PubMed 

    General protein information

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    Preferred Names
    heat shock protein 70 cognate 4
    Names
    70 kDa heat shock protein, cytosolic B 2
    Bap74
    CG4264-PA
    CG4264-PB
    CG4264-PC
    CG4264-PD
    CG4264-PE
    CG4264-PF
    CG4264-PG
    Hsc70-4-PA
    Hsc70-4-PB
    Hsc70-4-PC
    Hsc70-4-PD
    Hsc70-4-PE
    Hsc70-4-PF
    Hsc70-4-PG
    heat shock 70 kDa protein cognate 4
    heat shock 70-kDa protein cognate 4
    heat shock cognate 4
    heat shock cognate 70
    heat shock cognate protein 4
    heat shock cognate protein 70-4
    heat shock protein 70
    heat shock protein cognate 4
    heat-shock protein 70
    hsp cognate 4
    scattered

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NT_033777.3 Reference assembly

      Range
      15242687..15246614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_079632.6 → NP_524356.1  heat shock protein 70 cognate 4, isoform A [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_524356.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11147, Q3KN45, Q8SXQ4, Q9VFB0
      UniProtKB/TrEMBL
      C7LA75
      Related
      FBpp0082516
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional

    2. NM_001275657.1 → NP_001262586.1  heat shock protein 70 cognate 4, isoform G [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_001262586.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11147, Q3KN45, Q8SXQ4, Q9VFB0
      UniProtKB/TrEMBL
      C7LA75
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional

    3. NM_176502.2 → NP_788679.1  heat shock protein 70 cognate 4, isoform E [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788679.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11147, Q3KN45, Q8SXQ4, Q9VFB0
      UniProtKB/TrEMBL
      C7LA75
      Related
      FBpp0082514
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional

    4. NM_169626.2 → NP_731988.1  heat shock protein 70 cognate 4, isoform C [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731988.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11147, Q3KN45, Q8SXQ4, Q9VFB0
      UniProtKB/TrEMBL
      C7LA75
      Related
      FBpp0082517
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional

    5. NM_169627.2 → NP_731989.1  heat shock protein 70 cognate 4, isoform D [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731989.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11147, Q3KN45, Q8SXQ4, Q9VFB0
      UniProtKB/TrEMBL
      C7LA75
      Related
      FBpp0082518
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional

    6. NM_169625.2 → NP_731987.1  heat shock protein 70 cognate 4, isoform B [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_731987.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11147, Q3KN45, Q8SXQ4, Q9VFB0
      UniProtKB/TrEMBL
      C7LA75
      Related
      FBpp0082519
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional

    7. NM_176503.2 → NP_788680.1  heat shock protein 70 cognate 4, isoform F [Drosophila melanogaster]

      See identical proteins and their annotated locations for NP_788680.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P11147, Q3KN45, Q8SXQ4, Q9VFB0
      UniProtKB/TrEMBL
      C7LA75
      Related
      FBpp0082515
      Conserved Domains (2) summary
      cd10233
      Location:6 → 381
      HSPA1-2_6-8-like_NBD; Nucleotide-binding domain of HSPA1-A, -B, -L, HSPA-2, -6, -7, -8, and similar proteins
      PTZ00009
      Location:1 → 612
      PTZ00009; heat shock 70 kDa protein; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    C7LA75 C7LA75
    P11147.3 P11147

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