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    Med7 mediator complex subunit 7 [ Mus musculus (house mouse) ]

    Gene ID: 66213, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Med7provided by MGI
    Official Full Name
    mediator complex subunit 7provided by MGI
    Primary source
    MGI:MGI:1913463
    See related
    Ensembl:ENSMUSG00000020397 AllianceGenome:MGI:1913463
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crsp9; Crsp33; 1110063B05Rik
    Summary
    Predicted to enable transcription coregulator activity. Predicted to contribute to ubiquitin protein ligase activity. Acts upstream of or within stem cell population maintenance. Part of mediator complex. Is expressed in bladder; cerebral cortex ventricular layer; cortical plate; ovary; and renal interstitium. Orthologous to human MED7 (mediator complex subunit 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.7), placenta adult (RPKM 7.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Med7 in Genome Data Viewer
    Location:
    11 B1.1; 11 27.88 cM
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (46327742..46333548)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (46436936..46442721)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46157730-46157921 Neighboring gene IL2 inducible T cell kinase Neighboring gene predicted gene 12167 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46202936-46203219 Neighboring gene STARR-positive B cell enhancer ABC_E3943 Neighboring gene STARR-seq mESC enhancer starr_29325 Neighboring gene golgi associated RAB2 interactor 3 Neighboring gene CapStarr-seq enhancer MGSCv37_chr11:46234578-46234761 Neighboring gene STARR-seq mESC enhancer starr_29326 Neighboring gene STARR-positive B cell enhancer ABC_E1415 Neighboring gene predicted gene 12168 Neighboring gene hepatitis A virus cellular receptor 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mammalian mediator of transcriptional regulation and its possible role as an end-point of signal transduction pathways. Jiang YW, et al. Proc Natl Acad Sci U S A, 1998 Jul 21. PMID 9671713, Free PMC Article
    2. Characterization of gene expression in mouse blastocyst using single-pass sequencing of 3995 clones. Sasaki N, et al. Genomics, 1998 Apr 15. PMID 9598303
    3. Genome-wide analysis of translation reveals a critical role for deleted in azoospermia-like (Dazl) at the oocyte-to-zygote transition. Chen J, et al. Genes Dev, 2011 Apr 1. PMID 21460039, Free PMC Article
    4. Structural and functional organization of TRAP220, the TRAP/mediator subunit that is targeted by nuclear receptors. Malik S, et al. Mol Cell Biol, 2004 Sep. PMID 15340084, Free PMC Article
    5. Novel critical role of a human Mediator complex for basal RNA polymerase II transcription. Mittler G, et al. EMBO Rep, 2001 Sep. PMID 11559591, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables transcription coregulator activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA polymerase II preinitiation complex assembly NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription elongation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in positive regulation of transcription initiation by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within somatic stem cell population maintenance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    part_of core mediator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of mediator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    mediator of RNA polymerase II transcription subunit 7
    Names
    CRSP complex subunit 9
    cofactor required for Sp1 transcriptional activation subunit 9
    cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001104530.1 → NP_001098000.1  mediator of RNA polymerase II transcription subunit 7

      See identical proteins and their annotated locations for NP_001098000.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK010357, AL669948
      Consensus CDS
      CCDS36134.1
      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Related
      ENSMUSP00000020665.7, ENSMUST00000020665.13
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    2. NM_001104556.1 → NP_001098026.1  mediator of RNA polymerase II transcription subunit 7

      See identical proteins and their annotated locations for NP_001098026.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK010357, AK144918, AK147739, AK210054, AL669948, BE333513, C88719, CJ145922
      Consensus CDS
      CCDS36134.1
      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Related
      ENSMUSP00000131852.2, ENSMUST00000170928.8
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    3. NM_001104557.1 → NP_001098027.1  mediator of RNA polymerase II transcription subunit 7

      See identical proteins and their annotated locations for NP_001098027.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AK010357, AK144918, AK147739, AK210054, AL669948, BY135693, CF983034, CK030901, CK788351
      Consensus CDS
      CCDS36134.1
      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    4. NM_025426.3 → NP_079702.3  mediator of RNA polymerase II transcription subunit 7

      See identical proteins and their annotated locations for NP_079702.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript.
      Source sequence(s)
      AK010357, AK147739, AL669948, CJ145922
      Consensus CDS
      CCDS36134.1
      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Related
      ENSMUSP00000104855.4, ENSMUST00000109232.4
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      46327742..46333548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006533931.5 → XP_006533994.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006533994.1

      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    2. XM_006533932.5 → XP_006533995.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006533995.1

      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    3. XM_006533933.5 → XP_006533996.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006533996.1

      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein

    4. XM_006533934.5 → XP_006533997.1  mediator of RNA polymerase II transcription subunit 7 isoform X1

      See identical proteins and their annotated locations for XP_006533997.1

      UniProtKB/Swiss-Prot
      Q3UGV1, Q91VN3, Q9CWV8, Q9CZB6, Q9D0V9
      Conserved Domains (1) summary
      pfam05983
      Location:7 → 164
      Med7; MED7 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CZB6.2 GenPept UniProtKB/Swiss-Prot:Q9CZB6

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