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    septin2 septin 2 [ Danio rerio (zebrafish) ]

    Gene ID: 323457, updated on 11-Apr-2024

    Summary

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    Official Symbol
    septin2provided by ZNC
    Official Full Name
    septin 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-030131-911
    See related
    Ensembl:ENSDARG00000027590 AllianceGenome:ZFIN:ZDB-GENE-030131-911
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    nedd5; sept2; wu:fb52g01; wu:fb99a01
    Summary
    Predicted to enable GTPase activity and molecular adaptor activity. Predicted to be involved in several processes, including cilium assembly; cytoskeleton-dependent cytokinesis; and regulation of exocytosis. Predicted to act upstream of or within cell division. Predicted to be located in several cellular components, including ciliary membrane; cleavage furrow; and midbody. Predicted to be part of septin complex. Predicted to be active in cell division site; cytoskeleton; and synaptic vesicle. Is expressed in artery; notochord; and vein. Orthologous to human SEPTIN2 (septin 2). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See septin2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 2 NC_007113.7 (22592103..22615366)
    105 previous assembly GRCz10 (GCF_000002035.5) 2 NC_007113.6 (22936488..22959715)

    Chromosome 2 - NC_007113.7Genomic Context describing neighboring genes Neighboring gene claudin 18 Neighboring gene transcription factor Sox-14-like Neighboring gene serine/threonine kinase 25b Neighboring gene BCL2 family apoptosis regulator BOK b

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Phylogenetic and evolutionary analysis of the septin protein family in metazoan. Cao L, et al. FEBS Lett, 2007 Nov 27. PMID 17967425
    2. Analysis of septins across kingdoms reveals orthology and new motifs. Pan F, et al. BMC Evol Biol, 2007 Jul 1. PMID 17601340, Free PMC Article
    3. Online automated in vivo zebrafish phosphoproteomics: from large-scale analysis down to a single embryo. Lemeer S, et al. J Proteome Res, 2008 Apr. PMID 18307296
    4. Expressed sequence tag analysis of expression profiles of zebrafish testis and ovary. Zeng S, et al. Gene, 2002 Jul 10. PMID 12234666
    5. The zebrafish gene map defines ancestral vertebrate chromosomes. Woods IG, et al. Genome Res, 2005 Sep. PMID 16109975, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cell division IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cytoskeleton-dependent cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein localization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of exocytosis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell division site IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell projection IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in ciliary membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cleavage furrow IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in microtubule cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of septin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in septin ring IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in synaptic vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    septin-2
    Names
    neural precursor cell expressed, developmentally down-regulated 5

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001301360.1 → NP_001288289.1  septin-2

      See identical proteins and their annotated locations for NP_001288289.1

      Status: VALIDATED

      Source sequence(s)
      BX897733, FP102037
      UniProtKB/TrEMBL
      A0A8M1P0X4, F1QQN9
      Related
      ENSDARP00000105058.2, ENSDART00000130603.3
      Conserved Domains (2) summary
      COG5019
      Location:19 → 309
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:38 → 310
      Septin; Septin

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007113.7 Reference GRCz11 Primary Assembly

      Range
      22592103..22615366
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_009298508.3 → XP_009296783.1  septin-2 isoform X1

      UniProtKB/TrEMBL
      A0A8M3B088
      Related
      ENSDARP00000108257.3, ENSDART00000126891.5
      Conserved Domains (2) summary
      COG5019
      Location:19 → 341
      CDC3; Septin family protein [Cell cycle control, cell division, chromosome partitioning, Cytoskeleton]
      pfam00735
      Location:38 → 310
      Septin; Septin
    Nucleotide Protein Strain
    Heading Accession and Version

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