chia.3 chitinase, acidic.3 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: chia.3provided by ZNC
Official Full Name: chitinase, acidic.3provided by ZNC
Primary source: ZFIN:ZDB-GENE-040426-2891
See related: Ensembl:ENSDARG00000009612 AllianceGenome:ZFIN:ZDB-GENE-040426-2891
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: chioIb; zgc:55406; zgc:77912; wu:fd61a02; wu:fi13f01
Summary: Predicted to enable chitin binding activity and chitinase activity. Predicted to be involved in chitin catabolic process. Predicted to act upstream of or within carbohydrate metabolic process. Predicted to be active in extracellular region. Is expressed in gut and intestinal bulb. Human ortholog(s) of this gene implicated in asthma and schizophrenia. Orthologous to several human genes including CHIT1 (chitinase 1) and CHIA (chitinase acidic). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: chromosome: 11

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	11	NC_007122.7 (24013861..24016784, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	11	NC_007122.6 (23776004..23778927, complement)

Chromosome 11 - NC_007122.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A dual function in both innate immunity and food digestion in embryo is proposed for zebrafish Chi3.
Title: Functional characterization of chitinase-3 reveals involvement of chitinases in early embryo immunity in zebrafish.

Submit: New GeneRIF Correction

General gene information

Go to the top of the page Help

Markers

fi13f01.x1 (e-PCR)
- UniSTS:196825

fd61a02.x1 (e-PCR)
- UniSTS:195817

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables chitin binding	IEA Inferred from Electronic Annotation more info
enables chitinase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, acting on glycosyl bonds	IEA Inferred from Electronic Annotation more info
enables hydrolase activity, hydrolyzing O-glycosyl compounds	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within carbohydrate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in chitin catabolic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: chitinase, acidic.3

Names: chia3

NP_998378.1

EC 3.2.1.14

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_213213.1 → NP_998378.1 chitinase, acidic.3 precursor

See identical proteins and their annotated locations for NP_998378.1

Status: PROVISIONAL

Source sequence(s)

BC065893

UniProtKB/TrEMBL

A0A8N7V0D4, Q6NZZ8

Related

ENSDARP00000067816.3, ENSDART00000067817.6

Conserved Domains (3) summary

cd02872
Location:25 → 385

GH18_chitolectin_chitotriosidase; This conserved domain family includes a large number of catalytically inactive chitinase-like lectins (chitolectins) including YKL-39, YKL-40 (HCGP39), YM1, oviductin, and AMCase (acidic mammalian chitinase), as well as catalytically active ...

smart00494
Location:421 → 469

ChtBD2; Chitin-binding domain type 2

smart00636
Location:24 → 363

Glyco_18; Glyco_18 domain