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    acy3.2 aspartoacylase (aminocyclase) 3, tandem duplicate 2 [ Danio rerio (zebrafish) ]

    Gene ID: 436619, updated on 27-Mar-2024

    Summary

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    Official Symbol
    acy3.2provided by ZNC
    Official Full Name
    aspartoacylase (aminocyclase) 3, tandem duplicate 2provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-040718-37
    See related
    Ensembl:ENSDARG00000005525 AllianceGenome:ZFIN:ZDB-GENE-040718-37
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    zgc:92178; id:ibd5047
    Summary
    Predicted to enable aminoacylase activity. Predicted to be located in apical plasma membrane and cytoplasm. Predicted to be active in cytosol. Is expressed in pronephric duct; pronephric mesoderm; and pronephros. Orthologous to human ACY3 (aminoacylase 3). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    all
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    Genomic context

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    See acy3.2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 1 NC_007112.7 (52490361..52498009, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 1 NC_007112.6 (51855649..51863228, complement)

    Chromosome 1 - NC_007112.7Genomic Context describing neighboring genes Neighboring gene galactosidase, beta 1 Neighboring gene claudin domain containing 1b Neighboring gene uncharacterized LOC108190353 Neighboring gene aspartoacylase (aminocyclase) 3, tandem duplicate 1 Neighboring gene tachykinin receptor 3-like

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. A gene expression screen in zebrafish embryogenesis. Kudoh T, et al. Genome Res, 2001 Dec. PMID 11731487
    2. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    3. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article
    4. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables aminoacylase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in linear amides IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity, acting on ester bonds IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apical plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) B
    Names
    ACY-3.2
    aminoacylase-3.2
    aspartoacylase (aminocyclase) 3.2
    aspartoacylase-2B
    NP_001002347.1
    XP_021326628.1
    XP_021326647.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001002347.1 → NP_001002347.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) B

      See identical proteins and their annotated locations for NP_001002347.1

      Status: PROVISIONAL

      Source sequence(s)
      BC075914
      UniProtKB/Swiss-Prot
      A2BG59, Q6DHQ3
      UniProtKB/TrEMBL
      A0A8M9PI40
      Related
      ENSDARP00000023827.7, ENSDART00000004233.9
      Conserved Domains (1) summary
      cd06909
      Location:12 → 301
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007112.7 Reference GRCz11 Primary Assembly

      Range
      52490361..52498009 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_021470953.1 → XP_021326628.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) B isoform X1

      UniProtKB/Swiss-Prot
      A2BG59, Q6DHQ3
      UniProtKB/TrEMBL
      A0A8M9PI40
      Conserved Domains (1) summary
      cd06909
      Location:12 → 301
      M14_ASPA; Peptidase M14 Aspartoacylase (ASPA) subfamily

    2. XM_021470972.1 → XP_021326647.1  N-acyl-aromatic-L-amino acid amidohydrolase (carboxylate-forming) B isoform X2

      UniProtKB/TrEMBL
      A0A8M9P7H0
      Conserved Domains (1) summary
      cl11393
      Location:12 → 145
      Peptidase_M14_like; M14 family of metallocarboxypeptidases and related proteins
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6DHQ3.1 GenPept UniProtKB/Swiss-Prot:Q6DHQ3

    Gene LinkOut

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