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    tbc1d15 TBC1 domain family, member 15 [ Danio rerio (zebrafish) ]

    Gene ID: 492676, updated on 27-Mar-2024

    Summary

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    Official Symbol
    tbc1d15provided by ZNC
    Official Full Name
    TBC1 domain family, member 15provided by ZNC
    Primary source
    ZFIN:ZDB-GENE-041111-251
    See related
    Ensembl:ENSDARG00000057218 AllianceGenome:ZFIN:ZDB-GENE-041111-251
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Danio rerio
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
    Also known as
    im:7148793; si:ch211-218c6.6
    Summary
    Predicted to enable GTPase activator activity. Predicted to be involved in activation of GTPase activity and intracellular protein transport. Is expressed in polster. Orthologous to human TBC1D15 (TBC1 domain family member 15). [provided by Alliance of Genome Resources, Apr 2022]
    Orthologs
    human mouse all
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    Genomic context

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    See tbc1d15 in Genome Data Viewer
    Location:
    chromosome: 18
    Exon count:
    17
    Annotation release Status Assembly Chr Location
    106 current GRCz11 (GCF_000002035.6) 18 NC_007129.7 (17002161..17020301, complement)
    105 previous assembly GRCz10 (GCF_000002035.5) 18 NC_007129.6 (17013098..17031236, complement)

    Chromosome 18 - NC_007129.7Genomic Context describing neighboring genes Neighboring gene si:ch211-218c6.8 Neighboring gene tryptophan hydroxylase 2 (tryptophan 5-monooxygenase) Neighboring gene CTF8, chromosome transmission fidelity factor 8 homolog (S. cerevisiae) Neighboring gene hyaluronan synthase 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
    • BioProject: PRJEB1986
    • Analysis date: Fri Dec 8 19:48:10 2017

    Bibliography

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    Related articles in PubMed

    1. Molecular Evolution of Tryptophan Hydroxylases in Vertebrates: A Comparative Genomic Survey. Xu J, et al. Genes (Basel), 2019 Mar 8. PMID 30857219, Free PMC Article
    2. CD44a functions as a regulator of p53 signaling, apoptosis and autophagy in the antibacterial immune response. Cao L, et al. Commun Biol, 2022 Aug 30. PMID 36042265, Free PMC Article
    3. The NOTCH1-dependent HIF1α/VGLL4/IRF2BP2 oxygen sensing pathway triggers erythropoiesis terminal differentiation. Wang Y, et al. Redox Biol, 2020 Jan. PMID 31539803, Free PMC Article
    4. RFX transcription factors are essential for hearing in mice. Elkon R, et al. Nat Commun, 2015 Oct 15. PMID 26469318, Free PMC Article
    5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Strausberg RL, et al. Proc Natl Acad Sci U S A, 2002 Dec 24. PMID 12477932, Free PMC Article

    See all (6) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by ZFIN

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables superoxide dismutase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in activation of GTPase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    TBC1 domain family member 15
    NP_001166096.1
    XP_005159143.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001172625.1 → NP_001166096.1  TBC1 domain family member 15

      Status: VALIDATED

      Source sequence(s)
      AI883944, BC142890, EG570296, EH435207, EH461208
      UniProtKB/TrEMBL
      A0A8M1NT23
      Related
      ENSDARP00000111457.2, ENSDART00000129146.3
      Conserved Domains (2) summary
      pfam12068
      Location:4 → 219
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:321 → 556
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...Open this link in a new tab

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCz11 Primary Assembly

    Genomic

    1. NC_007129.7 Reference GRCz11 Primary Assembly

      Range
      17002161..17020301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005159086.4 → XP_005159143.1  TBC1 domain family member 15 isoform X1

      UniProtKB/TrEMBL
      A0A8M2B5M9
      Conserved Domains (2) summary
      pfam12068
      Location:4 → 220
      DUF3548; Domain of unknown function (DUF3548)
      smart00164
      Location:322 → 557
      TBC; Domain in Tre-2, BUB2p, and Cdc16p. Probable Rab-GAPs

    Reference GRCz11 ALT_DRER_TU_2

    Genomic

    1. NW_018395338.1 Reference GRCz11 ALT_DRER_TU_2

      Range
      204574..224730 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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