kif15 kinesin family member 15 [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: kif15provided by ZNC
Official Full Name: kinesin family member 15provided by ZNC
Primary source: ZFIN:ZDB-GENE-050622-16
See related: Ensembl:ENSDARG00000012073 AllianceGenome:ZFIN:ZDB-GENE-050622-16
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: wu:fb96c12; wu:fc51g12; wu:fe01e02; si:dkey-108k21.1
Summary: Predicted to enable ATP hydrolysis activity; microtubule binding activity; and microtubule motor activity. Acts upstream of or within regulation of axon extension. Predicted to be located in cytoplasm and spindle. Predicted to be part of kinesin complex. Predicted to be active in microtubule. Is expressed in several structures, including ectoderm; nervous system; pancreas primordium; spinal cord neural keel; and spinal cord neural tube. Orthologous to human KIF15 (kinesin family member 15). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 25

Exon count:: 35

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	25	NC_007136.7 (35068166..35095204, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	25	NC_007136.6 (34563208..34590215, complement)

Chromosome 25 - NC_007136.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

kif15 mutations facilitate axonal outgrowth during neuronal development and regeneration in zebrafish.
Title: Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)/Cas9-mediated kif15 mutations accelerate axonal outgrowth during neuronal development and regeneration in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fb96c12.x1 (e-PCR)
- UniSTS:187671

AW165099 (e-PCR)
- UniSTS:205883

fb23g02.x1 (e-PCR)
- UniSTS:203080

fb23h02.y1 (e-PCR)
- UniSTS:190329

fc51g12.y1 (e-PCR)
- UniSTS:194041

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IEA Inferred from Electronic Annotation more info
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule motor activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within microtubule-based movement	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within posterior lateral line development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of axon extension	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within semicircular canal development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: kinesin-like protein KIF15

Names: knsl7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001423817.1 → NP_001410746.1 kinesin-like protein KIF15

Status: VALIDATED

Source sequence(s)

CU302436

UniProtKB/TrEMBL

A0A8M1REI0

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007136.7 Reference GRCz11 Primary Assembly

Range

35068166..35095204 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_002666923.5 → XP_002666969.1 kinesin-like protein KIF15

UniProtKB/TrEMBL

A0A0R4IN98

Related

ENSDARP00000090639.4, ENSDART00000099866.6

Conserved Domains (9) summary

smart00129
Location:19 → 364

KISc; Kinesin motor, catalytic domain. ATPase

COG0419
Location:371 → 1007

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

TIGR04523
Location:709 → 1360

Mplasa_alph_rch; helix-rich Mycoplasma protein

cd01373
Location:18 → 367

KISc_KLP2_like; Kinesin motor domain, KIF15-like subgroup

pfam10211
Location:602 → 658

Ax_dynein_light; Axonemal dynein light chain

pfam12711
Location:462 → 547

Kinesin-relat_1; Kinesin motor

pfam15908
Location:1262 → 1372

HMMR_C; Hyaluronan mediated motility receptor C-terminal

cd16269
Location:776 → 788

GBP_C; coiled coil [structural motif]

cl20817
Location:707 → 805

GBP_C; Guanylate-binding protein, C-terminal domain