dyrk1aa dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: dyrk1aaprovided by ZNC
Official Full Name: dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A, aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-050302-29
See related: Ensembl:ENSDARG00000063570 AllianceGenome:ZFIN:ZDB-GENE-050302-29
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: dyrk1a; im:6962097; zgc:158359
Summary: Predicted to enable protein serine/threonine kinase activity and transcription coactivator activity. Acts upstream of or within angiogenesis and brain development. Predicted to be active in nucleus. Is expressed in endothelial cell; heart; nervous system; and pharyngeal arch. Used to study autism spectrum disorder. Human ortholog(s) of this gene implicated in Down syndrome; autism spectrum disorder; autosomal dominant non-syndromic intellectual disability 7; and intellectual disability. Orthologous to human DYRK1A (dual specificity tyrosine phosphorylation regulated kinase 1A). [provided by Alliance of Genome Resources, Apr 2022]
Annotation information: Annotation category: suggests misassembly; Annotation category: partial on reference assembly
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 10

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	10	NC_007121.7 (61611..76400, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	10	NC_007121.6 (61678..74424, complement)

Chromosome 10 - NC_007121.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression.
Title: A novel inhibitor rescues cerebellar defects in a zebrafish model of Down syndrome-associated kinase Dyrk1A overexpression.
DYRK1A plays an essential role in angiogenesis and in maintenance of the developing cerebral vasculature via regulation of calcium signaling.
Title: Vascular defects of DYRK1A knockouts are ameliorated by modulating calcium signaling in zebrafish.
The dyrk1aa KO zebrafish showed impaired social preference compared with WT in the social behavior test.
Title: The Body Size of Stimulus Conspecifics Affects Social Preference in a Binary Choice Task in Wild-Type, But Not in dyrk1aa Mutant, Zebrafish.
overexpression of DYRK1A, a candidate gene of Down's syndrome, impairs PGCs development during early embryogenesis by altering key factors in embryos.
Title: Overexpression of DYRK1A, a Down Syndrome Candidate gene, Impairs Primordial Germ Cells Maintenance and Migration in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

G45257 (e-PCR)
- UniSTS:106059

G47904 (e-PCR)
- UniSTS:108671

fb83f02.x1 (e-PCR)
- UniSTS:203496

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II CTD heptapeptide repeat kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	IEA Inferred from Electronic Annotation more info
enables nucleotide binding	IEA Inferred from Electronic Annotation more info
enables protein kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine/tyrosine kinase activity	IEA Inferred from Electronic Annotation more info
enables transcription coactivator activity	IBA Inferred from Biological aspect of Ancestor more info
enables transferase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within angiogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in peptidyl-serine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
involved_in peptidyl-threonine phosphorylation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within phosphorylation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of DNA-templated transcription	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in nuclear speck	IEA Inferred from Electronic Annotation more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: dual specificity tyrosine-phosphorylation-regulated kinase 1A

NP_001074158.1

EC 2.7.12.1

NP_001334668.1

EC 2.7.12.1

XP_009303309.2

EC 2.7.12.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001080689.1 → NP_001074158.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 1

See identical proteins and their annotated locations for NP_001074158.1

Status: VALIDATED

Source sequence(s)

BC129212

UniProtKB/TrEMBL

A1L1U2

Related

ENSDARP00000090845.4, ENSDART00000100073.5

Conserved Domains (2) summary

smart00220
Location:164 → 483

S_TKc; Serine/Threonine protein kinases, catalytic domain

cd14226
Location:151 → 488

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1
NM_001347739.1 → NP_001334668.1 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform 2

Status: VALIDATED

Source sequence(s)

CABZ01076953, CABZ01076954, CU633885, EB980854, EH997539

UniProtKB/TrEMBL

A0A8M1P9M8

Related

ENSDARP00000152407.1, ENSDART00000186560.1

Conserved Domains (1) summary

cd14226
Location:147 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007121.7 Reference GRCz11 Primary Assembly

Range

61611..76400 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009305034.3 → XP_009303309.2 dual specificity tyrosine-phosphorylation-regulated kinase 1A isoform X1

UniProtKB/TrEMBL

A0A8M1P9M8

Conserved Domains (1) summary

cd14226
Location:147 → 484

PKc_DYRK1; Catalytic domain of the protein kinase, Dual-specificity tYrosine-phosphorylated and -Regulated Kinase 1