fsta follistatin a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: fstaprovided by ZNC
Official Full Name: follistatin aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-990714-11
See related: Ensembl:ENSDARG00000052846 AllianceGenome:ZFIN:ZDB-GENE-990714-11
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: fs; fst; fst1; cb446; fd07h10; wu:fd07h10
Summary: Predicted to enable activin binding activity. Acts upstream of or within determination of dorsal identity; embryonic organ morphogenesis; and midbrain development. Predicted to be active in extracellular space. Is expressed in several structures, including central nervous system; head; mesoderm; neural tube; and ovary. Human ortholog(s) of this gene implicated in polycystic ovary syndrome. Orthologous to human FST (follistatin). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 5

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	5	NC_007116.7 (40504910..40510465, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	5	NC_007116.6 (39904757..39910273, complement)

Chromosome 5 - NC_007116.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation.
Title: The roles of follistatin 1 in regulation of zebrafish fecundity and sexual differentiation.
Results suggest that Follistatin 1 overexpression can promote zebrafish muscle growth by enhancing myofiber hyperplasia.
Title: Enhanced hyperplasia in muscles of transgenic zebrafish expressing Follistatin1.
fst, a bone morphogenetic protein antagonist expressed in gastrulation, is dispensable for neural crest induction.
Title: Signals derived from the underlying mesoderm are dispensable for zebrafish neural crest induction.
Follistatin increased with growth of ovary. Increased significantly during vitellogenesis. Gradually increased during daily ovulatory cycle.
Title: Developmental profiles of activin betaA, betaB, and follistatin expression in the zebrafish ovary: evidence for their differential roles during sexual maturation and ovulatory cycle.

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General gene information

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Markers

fd07h10.x1 (e-PCR)
- UniSTS:204086

fa06c05.s1 (e-PCR)
- UniSTS:202228

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables activin binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within determination of dorsal identity	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within dorsal/ventral pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within embryonic viscerocranium morphogenesis	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within midbrain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in multicellular organism development	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of activin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within oocyte differentiation	NAS Non-traceable Author Statement more info	PubMed
acts_upstream_of_or_within otic placode formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of BMP signaling pathway	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: follistatin-A

Names: activin-binding protein; follistatin-1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_131037.3 → NP_571112.3 follistatin-A precursor

See identical proteins and their annotated locations for NP_571112.3

Status: VALIDATED

Source sequence(s)

BX537294

UniProtKB/Swiss-Prot

A5PMK3, A7MC96, Q6DC45, Q9YHV4

Related

ENSDARP00000051064.4, ENSDART00000051065.6

Conserved Domains (2) summary

smart00280
Location:120 → 167

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:199 → 242

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007116.7 Reference GRCz11 Primary Assembly

Range

40504910..40510465 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009301618.3 → XP_009299893.1 follistatin-A isoform X2

UniProtKB/TrEMBL

A0A8M3AZS1

Conserved Domains (2) summary

smart00280
Location:120 → 167

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:199 → 242

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...
XM_005165257.4 → XP_005165314.1 follistatin-A isoform X1

UniProtKB/TrEMBL

A0A8M2BCI8

Related

ENSDARP00000122591.1, ENSDART00000146237.3

Conserved Domains (2) summary

smart00280
Location:120 → 167

KAZAL; Kazal type serine protease inhibitors

cd00104
Location:199 → 242

KAZAL_FS; Kazal type serine protease inhibitors and follistatin-like domains. Kazal inhibitors inhibit serine proteases, such as, trypsin, chyomotrypsin, avian ovomucoids, and elastases. The inhibitory domain has one reactive site peptide bond, which serves the ...