mafaa MAF bZIP transcription factor Aa [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: mafaaprovided by ZNC
Official Full Name: MAF bZIP transcription factor Aaprovided by ZNC
Primary source: ZFIN:ZDB-GENE-010605-3
See related: Ensembl:ENSDARG00000044155 AllianceGenome:ZFIN:ZDB-GENE-010605-3
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: mafa; mafl; SMaf1
Summary: Enables sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to act upstream of or within regulation of transcription, DNA-templated. Predicted to be active in nucleus. Is expressed in myotome; nervous system; neural tube; and somite. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Orthologous to human MAFA (MAF bZIP transcription factor A). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 6

Exon count:: 1

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	6	NC_007117.7 (32699363..32703518, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	6	NC_007117.6 (32714673..32718828, complement)

Chromosome 6 - NC_007117.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: transcription factor MafAa

Names: Transcription factor MafA; somite Maf1; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog A; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog Aa; v-maf musculoaponeurotic fibrosarcoma oncogene family, protein L; v-maf musculoaponeurotic fibrosarcoma oncogene homolog A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001082940.2 → NP_001076409.1 transcription factor MafAa

See identical proteins and their annotated locations for NP_001076409.1

Status: VALIDATED

Source sequence(s)

CU694370, EH441535, EH467419

UniProtKB/Swiss-Prot

A3KMR8, Q98UK3

UniProtKB/TrEMBL

B3DGB3

Related

ENSDARP00000064832.4, ENSDART00000064833.5

Conserved Domains (2) summary

cd14718
Location:218 → 287

bZIP_Maf_large; Basic leucine zipper (bZIP) domain of large musculoaponeurotic fibrosarcoma (Maf) proteins: a DNA-binding and dimerization domain

pfam08383
Location:106 → 139

Maf_N; Maf N-terminal region