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    Sbsn suprabasin [ Mus musculus (house mouse) ]

    Gene ID: 282619, updated on 12-May-2024

    Summary

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    Official Symbol
    Sbsnprovided by MGI
    Official Full Name
    suprabasinprovided by MGI
    Primary source
    MGI:MGI:2446326
    See related
    Ensembl:ENSMUSG00000046056 AllianceGenome:MGI:2446326
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1110005D19Rik
    Summary
    Located in cytoplasm. Is expressed in several structures, including alimentary system; nose; and skin. Orthologous to human SBSN (suprabasin). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in placenta adult (RPKM 17.4), stomach adult (RPKM 9.3) and 15 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Sbsn in Genome Data Viewer
    Location:
    7 B1; 7 19.24 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (30432099..30455559)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (30732674..30756134)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E9108 Neighboring gene ATPase, H+/K+ exchanging, gastric, alpha polypeptide Neighboring gene STARR-positive B cell enhancer ABC_E11349 Neighboring gene transmembrane protein 147 Neighboring gene glyceraldehyde-3-phosphate dehydrogenase, spermatogenic Neighboring gene dermokine Neighboring gene keratinocyte differentiation associated protein

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling. Zhou Z, et al. Br J Cancer, 2022 Jul. PMID 35484216, Free PMC Article
    2. Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies. Hubackova S, et al. Mol Oncol, 2019 Jul. PMID 30919591, Free PMC Article
    3. Suprabasin as a novel tumor endothelial cell marker. Alam MT, et al. Cancer Sci, 2014 Dec. PMID 25283635, Free PMC Article
    4. Suprabasin-null mice retain skin barrier function and show high contact hypersensitivity to nickel upon oral nickel loading. Nakazawa S, et al. Sci Rep, 2020 Sep 3. PMID 32884021, Free PMC Article
    5. Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor. Park GT, et al. J Biol Chem, 2002 Nov 22. PMID 12228223, Free PMC Article

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling.
      Title: SBSN drives bladder cancer metastasis via EGFR/SRC/STAT3 signalling.
    2. SBSN expression was observed in human clinical specimens of colon and ovarian carcinomas, as well as in circulating tumour cells and metastases of the 4T1 mouse model. The association of SBSN expression with progressive stages of cancer development indicates its role in cancer evolution and therapy resistance.
      Title: Interferon-regulated suprabasin is essential for stress-induced stem-like cell conversion and therapy resistance of human malignancies.
    3. Findings suggest that SBSN is involved in the angiogenic potential of tumor endothelial cells (TEC) and may be a novel TEC marker.
      Title: Suprabasin as a novel tumor endothelial cell marker.
    4. Sbsn, Dmkn and Krtdap are coordinately expressed during epidermal morphogenesis.
      Title: Transcriptional profiling of developing mouse epidermis reveals novel patterns of coordinated gene expression.
    5. These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation.
      Title: Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor.
    6. These results indicate that the suprabasin protein potentially plays a role in the process of epidermal differentiation
      Title: Suprabasin, a novel epidermal differentiation marker and potential cornified envelope precursor.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    suprabasin
    Names
    suprabasal-specific protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001083903.1 → NP_001077372.1  suprabasin isoform 2 precursor

      See identical proteins and their annotated locations for NP_001077372.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 5' coding region, compared to variant 1. The resulting protein (isoform 2) is shorter than isoform 1 and lacks the repetitive central domain rich in glycine and alanine found in isoform 1.
      Source sequence(s)
      AI507307, BC051531
      Consensus CDS
      CCDS59725.1
      UniProtKB/TrEMBL
      A0A0R4J2A5, S4R2I1
      Related
      ENSMUSP00000138561.2, ENSMUST00000182229.8

    2. NM_172205.3 → NP_757342.2  suprabasin isoform 1 precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1). The protein contains a repetitive central domain rich in glycine and alanine.
      Source sequence(s)
      AA791703, AC167978, AI507307
      Consensus CDS
      CCDS39891.1
      UniProtKB/TrEMBL
      E9QPB2
      Related
      ENSMUSP00000079362.6, ENSMUST00000080518.14
      Conserved Domains (1) summary
      pfam05262
      Location:462 → 600
      Borrelia_P83; Borrelia P83/100 protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      30432099..30455559
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030242650.1 → XP_030098510.1  suprabasin isoform X1

      UniProtKB/TrEMBL
      E9QPB2
      Conserved Domains (1) summary
      pfam05262
      Location:462 → 600
      Borrelia_P83; Borrelia P83/100 protein

    2. XM_006540028.3 → XP_006540091.1  suprabasin isoform X2

      Conserved Domains (1) summary
      pfam05262
      Location:452 → 590
      Borrelia_P83; Borrelia P83/100 protein

    3. XM_006540029.2 → XP_006540092.1  suprabasin isoform X3

    4. XM_030242652.1 → XP_030098512.1  suprabasin isoform X4

      UniProtKB/TrEMBL
      A0A0R4J2A5, S4R2I1

    5. XM_030242651.1 → XP_030098511.1  suprabasin isoform X1

      UniProtKB/TrEMBL
      E9QPB2
      Conserved Domains (1) summary
      pfam05262
      Location:462 → 600
      Borrelia_P83; Borrelia P83/100 protein
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CIT9.1 GenPept UniProtKB/Swiss-Prot:Q8CIT9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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