MYCT1 MYC target 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: MYCT1provided by HGNC
Official Full Name: MYC target 1provided by HGNC
Primary source: HGNC:HGNC:23172
See related: Ensembl:ENSG00000120279 MIM:616805; AllianceGenome:HGNC:23172
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MTLC
Summary: Predicted to act upstream of or within hematopoietic stem cell homeostasis. Located in nucleoplasm. [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in spleen (RPKM 14.8), fat (RPKM 8.8) and 22 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 6q25.2

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	6	NC_000006.12 (152697897..152747181)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	6	NC_060930.1 (153899213..153948502)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	6	NC_000006.11 (153019032..153049320)

Chromosome 6 - NC_000006.12 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.
Title: MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription.
MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.
Title: MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment.
Nitrosative stress induces downregulation of ribosomal protein genes via MYCT1 in vascular smooth muscle cells.
Title: Nitrosative stress induces downregulation of ribosomal protein genes via MYCT1 in vascular smooth muscle cells.
MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway.
Title: MYCT1 inhibits the EMT and migration of laryngeal cancer cells via the SP1/miR-629-3p/ESRP2 pathway.
Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
Title: Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity.
MYCT1 may synergistically interact with MAX as a co-transcription factor or a component of MAX transcriptional complex, to transcriptionally regulate the expression of miR-181a, which, in turn, decreases NPM1 expression at post-transcriptional levels, leading to enhanced apoptosis in laryngeal cancer cells
Title: MYCT1 represses apoptosis of laryngeal cancerous cells through the MAX/miR-181a/NPM1 pathway.
miR-632 was upregulated and MYCT1 was downregulated in HCC. High miR-632 or low MYCT1 expression was shown as a predictor for poor overall survival of HCC patients. The study also found miR-632 was able to regulate HCC cell growth and invasion through targeting the expression of MYCT1.
Title: miR-632 Functions as Oncogene in Hepatocellular Carcinoma via Targeting MYCT1.
YY1 promotes proliferation and migration with suppression of apoptosis via directly inhibiting MYCT1 in laryngeal cancer cells, suggesting that YY1 is a useful target as a potential oncogene in laryngeal cancer development and progression.
Title: YY1 directly suppresses MYCT1 leading to laryngeal tumorigenesis and progress.
Overexpression of MYCT1, decreased cell viability under serum deprivation and increased tumour cell migration ability.
Title: Transmembrane domain is crucial to the subcellular localization and function of Myc target 1.
this study has provided the theoretical basis for the further discussion of the effect and mechanism of action of MTLC in the occurrence of laryngeal cancer.
Title: Bioinformatic analysis of c-Myc target from laryngeal cancer cell gene of laryngeal cancer.

Submit: New GeneRIF Correction See all GeneRIFs (15)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

STS-AA004369 (e-PCR)
- UniSTS:76847

RH45552 (e-PCR)
- UniSTS:21295

RH92601 (e-PCR)
- UniSTS:86341

RH69853 (e-PCR)
- UniSTS:30151

D6S1536E (e-PCR)
- UniSTS:154080

Gene Ontology Provided by GOA

Process	Evidence Code	Pubs
involved_in hematopoietic stem cell homeostasis	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info
located_in nuclear body	IDA Inferred from Direct Assay more info
is_active_in nucleoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: myc target protein 1

Names: myc target in myeloid cells 1; myc target in myeloid cells protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001371624.1 → NP_001358553.1 myc target protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL390960

UniProtKB/TrEMBL

D6Q1S4, H0YDV5

Conserved Domains (1) summary

pfam15179
Location:1 → 186

Myc_target_1; Myc target protein 1
NM_001371625.1 → NP_001358554.1 myc target protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL390960

UniProtKB/TrEMBL

D6Q1S4, H0YDV5

Conserved Domains (1) summary

pfam15179
Location:1 → 186

Myc_target_1; Myc target protein 1
NM_001371626.1 → NP_001358555.1 myc target protein 1 isoform 2

Status: VALIDATED

Source sequence(s)

AL390960

UniProtKB/TrEMBL

D6Q1S4, H0YDV5

Related

ENSP00000434396.1, ENST00000532295.1

Conserved Domains (1) summary

pfam15179
Location:1 → 186

Myc_target_1; Myc target protein 1
NM_025107.3 → NP_079383.2 myc target protein 1 isoform 1

See identical proteins and their annotated locations for NP_079383.2

Status: VALIDATED

Source sequence(s)

AL390960

Consensus CDS

CCDS5239.1

UniProtKB/Swiss-Prot

Q8N396, Q8N699, Q8TBE8, Q9H763

UniProtKB/TrEMBL

H0YDV5

Related

ENSP00000356214.5, ENST00000367245.6

Conserved Domains (1) summary

pfam15179
Location:49 → 234

Myc_target_1; Myc target protein 1