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    Armc2 armadillo repeat containing 2 [ Mus musculus (house mouse) ]

    Gene ID: 213402, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Armc2provided by MGI
    Official Full Name
    armadillo repeat containing 2provided by MGI
    Primary source
    MGI:MGI:1916449
    See related
    Ensembl:ENSMUSG00000071324 AllianceGenome:MGI:1916449
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2610018I05Rik
    Summary
    Involved in sperm axoneme assembly. Is expressed in brain; reproductive system; respiratory system; spinal cord; and thyroid gland. Used to study male infertility. Human ortholog(s) of this gene implicated in spermatogenic failure 38. Orthologous to human ARMC2 (armadillo repeat containing 2). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in testis adult (RPKM 4.7), heart adult (RPKM 1.8) and 9 other tissues See more
    Orthologs
    human all
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    Genomic context

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    Location:
    10 B2; 10 22.77 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (41784284..41894383, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (41908463..42018382, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene coiled-coil domain containing 162 Neighboring gene STARR-positive B cell enhancer ABC_E5128 Neighboring gene microRNA 3473b Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41472075-41472184 Neighboring gene centrosomal protein 57-like 1 Neighboring gene cDNA sequence BC048559 Neighboring gene STARR-seq mESC enhancer starr_26466 Neighboring gene STARR-seq mESC enhancer starr_26467 Neighboring gene STARR-seq mESC enhancer starr_26468 Neighboring gene STARR-seq mESC enhancer starr_26469 Neighboring gene sestrin 1 Neighboring gene STARR-seq mESC enhancer starr_26471 Neighboring gene STARR-seq mESC enhancer starr_26472 Neighboring gene annexin A2 pseudogene Neighboring gene predicted gene, 33058 Neighboring gene STARR-seq mESC enhancer starr_26473 Neighboring gene RIKEN cDNA 1700016J18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr10:41777238-41777421 Neighboring gene STARR-seq mESC enhancer starr_26475 Neighboring gene predicted gene, 51798 Neighboring gene thymine DNA glycosylase, pseudogene 2 Neighboring gene predicted gene, 40630

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bi-allelic Mutations in ARMC2 Lead to Severe Astheno-Teratozoospermia Due to Sperm Flagellum Malformations in Humans and Mice. Coutton C, et al. Am J Hum Genet, 2019 Feb 7. PMID 30686508, Free PMC Article
    2. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    3. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 
    • Endonuclease-mediated (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cilium organization IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within flagellated sperm motility IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sperm axoneme assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in sperm axoneme assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    armadillo repeat-containing protein 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001034858.3 → NP_001030030.2  armadillo repeat-containing protein 2

      See identical proteins and their annotated locations for NP_001030030.2

      Status: VALIDATED

      Source sequence(s)
      AC165442, AK131686, AK141039, BM942469, BX636716, BY123606
      UniProtKB/Swiss-Prot
      Q3URY6
      Related
      ENSMUSP00000093397.5, ENSMUST00000095729.11
      Conserved Domains (3) summary
      PHA03247
      Location:17 → 192
      PHA03247; large tegument protein UL36; Provisional
      pfam05804
      Location:343 → 573
      KAP; Kinesin-associated protein (KAP)
      sd00043
      Location:693 → 733
      ARM; armadillo repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      41784284..41894383 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512653.4 → XP_006512716.1  armadillo repeat-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006512716.1

      Conserved Domains (1) summary
      sd00043
      Location:412 → 452
      ARM; armadillo repeat [structural motif]

    2. XM_006512654.2 → XP_006512717.1  armadillo repeat-containing protein 2 isoform X2

      See identical proteins and their annotated locations for XP_006512717.1

      Conserved Domains (1) summary
      sd00043
      Location:412 → 452
      ARM; armadillo repeat [structural motif]

    3. XM_011243159.2 → XP_011241461.1  armadillo repeat-containing protein 2 isoform X1

      See identical proteins and their annotated locations for XP_011241461.1

      UniProtKB/Swiss-Prot
      Q3URY6
      Conserved Domains (3) summary
      PHA03247
      Location:17 → 192
      PHA03247; large tegument protein UL36; Provisional
      pfam05804
      Location:343 → 573
      KAP; Kinesin-associated protein (KAP)
      sd00043
      Location:693 → 733
      ARM; armadillo repeat [structural motif]

    RNA

    1. XR_003948649.2 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q3URY6.3 GenPept UniProtKB/Swiss-Prot:Q3URY6

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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