U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Dnajc28 DnaJ heat shock protein family (Hsp40) member C28 [ Mus musculus (house mouse) ]

    Gene ID: 246738, updated on 30-Apr-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    Dnajc28provided by MGI
    Official Full Name
    DnaJ heat shock protein family (Hsp40) member C28provided by MGI
    Primary source
    MGI:MGI:2181053
    See related
    Ensembl:ENSMUSG00000039763 AllianceGenome:MGI:2181053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ORF28
    Summary
    Predicted to be involved in Golgi organization; Golgi vesicle prefusion complex stabilization; and retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum. Predicted to be part of Golgi transport complex. Is expressed in several structures, including alimentary system; brain; hemolymphoid system gland; reproductive system; and respiratory system. Orthologous to human DNAJC28 (DnaJ heat shock protein family (Hsp40) member C28). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in heart adult (RPKM 4.0), testis adult (RPKM 2.8) and 24 other tissues See more
    Orthologs
    human all
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    Location:
    16 C3.3; 16 53.17 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (91411142..91415931, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (91614257..91618999, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_41480 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B Neighboring gene CapStarr-seq enhancer MGSCv37_chr16:91588013-91588235 Neighboring gene STARR-positive B cell enhancer ABC_E3173 Neighboring gene STARR-positive B cell enhancer mm9_chr16:91619128-91619428 Neighboring gene phosphoribosylglycinamide formyltransferase Neighboring gene STARR-positive B cell enhancer ABC_E3174 Neighboring gene STARR-positive B cell enhancer ABC_E7475 Neighboring gene predicted gene, 36712 Neighboring gene Son DNA binding protein

    Genomic regions, transcripts, and products

    Go to the top of the page Help

    Go to nucleotide: Graphics FASTA GenBank

    Expression

    Go to the top of the page Help
    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. A gene expression map of human chromosome 21 orthologues in the mouse. Gitton Y, et al. Nature, 2002 Dec 5. PMID 12466855
    2. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

    Go to the top of the page Help

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (1) 

    General gene information

    Go to the top of the page Help

    Markers

    Homology

    Clone Names

    • MGC27620

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  

    General protein information

    Go to the top of the page Help
    Preferred Names
    dnaJ homolog subfamily C member 28
    Names
    DnaJ (Hsp40) homolog, subfamily C, member 28

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099738.1 → NP_001093208.1  dnaJ homolog subfamily C member 28 isoform 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC131691, AK081175, AV328433, BB535506, BB622009, BU520154
      Consensus CDS
      CCDS49912.1
      UniProtKB/TrEMBL
      E9Q1L7
      Related
      ENSMUSP00000132288.2, ENSMUST00000169982.2
      Conserved Domains (3) summary
      PLN03085
      Location:224 → 362
      PLN03085; nucleobase:cation symporter-1; Provisional
      pfam00226
      Location:72 → 132
      DnaJ; DnaJ domain
      pfam09350
      Location:227 → 295
      DUF1992; Domain of unknown function (DUF1992)

    2. NM_138664.2 → NP_619605.2  dnaJ homolog subfamily C member 28 isoform 2

      See identical proteins and their annotated locations for NP_619605.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and initiates translation at a downstream AUG, compared to variant 1. The resulting protein (isoform 2) is shorter at the N-terminus, compared to isoform 1.
      Source sequence(s)
      AC131691, AK081175, AV328433, BB535506, BB622009
      Consensus CDS
      CCDS49911.1
      UniProtKB/Swiss-Prot
      Q8VCE1, Q99JX0
      UniProtKB/TrEMBL
      Q8C4S9
      Related
      ENSMUSP00000048113.9, ENSMUST00000049244.10
      Conserved Domains (4) summary
      PLN03085
      Location:200 → 338
      PLN03085; nucleobase:cation symporter-1; Provisional
      COG2214
      Location:45 → 187
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:48 → 108
      DnaJ; DnaJ domain
      pfam09350
      Location:203 → 271
      DUF1992; Domain of unknown function (DUF1992)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      91411142..91415931 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036159930.1 → XP_036015823.1  dnaJ homolog subfamily C member 28 isoform X1

      UniProtKB/Swiss-Prot
      Q8VCE1, Q99JX0
      UniProtKB/TrEMBL
      Q8C4S9
      Conserved Domains (4) summary
      PLN03085
      Location:200 → 338
      PLN03085; nucleobase:cation symporter-1; Provisional
      COG2214
      Location:45 → 187
      CbpA; Curved DNA-binding protein CbpA, contains a DnaJ-like domain [Transcription]
      pfam00226
      Location:48 → 108
      DnaJ; DnaJ domain
      pfam09350
      Location:203 → 271
      DUF1992; Domain of unknown function (DUF1992)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VCE1.2 GenPept UniProtKB/Swiss-Prot:Q8VCE1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
    Tools
    Miscellaneous