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    Paqr7 progestin and adipoQ receptor family member VII [ Mus musculus (house mouse) ]

    Gene ID: 71904, updated on 9-May-2024

    Summary

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    Official Symbol
    Paqr7provided by MGI
    Official Full Name
    progestin and adipoQ receptor family member VIIprovided by MGI
    Primary source
    MGI:MGI:1919154
    See related
    Ensembl:ENSMUSG00000037348 AllianceGenome:MGI:1919154
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mPR; Mpra; PGLP; mPR alpha; 2310021M12Rik
    Summary
    Predicted to enable steroid binding activity and steroid hormone receptor activity. Predicted to be involved in response to steroid hormone. Predicted to act upstream of or within oogenesis. Predicted to be located in membrane. Predicted to be integral component of membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including brain; genitourinary system; gut; hemolymphoid system gland; and integumental system. Orthologous to human PAQR7 (progestin and adipoQ receptor family member 7). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in adrenal adult (RPKM 26.7), lung adult (RPKM 26.0) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Paqr7 in Genome Data Viewer
    Location:
    4 D2.3; 4 66.8 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (134224315..134237548)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (134496761..134510237)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_11679 Neighboring gene stathmin 1 Neighboring gene STARR-positive B cell enhancer ABC_E9602 Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:134051274-134051427 Neighboring gene ribosomal protein 10 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E4680 Neighboring gene aurora kinase A and ninein interacting protein Neighboring gene mitochondrial fission regulator 1-like Neighboring gene STARR-positive B cell enhancer mm9_chr4:134091101-134091402

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain. Frye CA, et al. Steroids, 2014 Mar. PMID 24269738, Free PMC Article
    2. Membrane progestin receptors alpha and gamma in renal epithelium. Lemale J, et al. Biochim Biophys Acta, 2008 Dec. PMID 18722485
    3. Identification of promethin and PGLP as two novel up-regulated genes in PPARgamma1-induced adipogenic mouse liver. Yu S, et al. Biochimie, 2004 Nov. PMID 15589683
    4. Activation of enteroendocrine membrane progesterone receptors promotes incretin secretion and improves glucose tolerance in mice. Flock GB, et al. Diabetes, 2013 Jan. PMID 22933106, Free PMC Article
    5. Pancreatic expression and mitochondrial localization of the progestin-adipoQ receptor PAQR10. Góñez LJ, et al. Mol Med, 2008 Nov-Dec. PMID 18769639, Free PMC Article

    See all (23) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
      Title: Progestin and adipoQ receptor 7 (PAQR7) mediate the anti-apoptotic effect of P4 on human granulosa cells and its deficiency reduces ovarian function in female mice.
    2. Paqr7 and Paqr8 are expressed in the midbrain ventral tegmental area of proestrous mice.
      Title: Progesterone-facilitated lordosis of estradiol-primed mice is attenuated by knocking down expression of membrane progestin receptors in the midbrain.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables lipid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables nuclear steroid receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables steroid binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within multicellular organism development IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within oogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to steroid hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    membrane progestin receptor alpha
    Names
    PPAR-gamma-induced liver protein
    membrane progesterone P4 receptor alpha
    membrane progesterone receptor alpha
    progesterone and adipoQ receptor family member 7
    progestin and adipoQ receptor family member 7

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001285845.2 → NP_001272774.1  membrane progestin receptor alpha

      See identical proteins and their annotated locations for NP_001272774.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All variants (1 through 5) encode the same protein.
      Source sequence(s)
      AL669982
      Consensus CDS
      CCDS18773.1
      UniProtKB/Swiss-Prot
      Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
      UniProtKB/TrEMBL
      Q3TT73
      Conserved Domains (1) summary
      pfam03006
      Location:65 → 289
      HlyIII; Haemolysin-III related

    2. NM_001285846.2 → NP_001272775.1  membrane progestin receptor alpha

      See identical proteins and their annotated locations for NP_001272775.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
      Source sequence(s)
      AL669982
      Consensus CDS
      CCDS18773.1
      UniProtKB/Swiss-Prot
      Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
      UniProtKB/TrEMBL
      Q3TT73
      Conserved Domains (1) summary
      pfam03006
      Location:65 → 289
      HlyIII; Haemolysin-III related

    3. NM_001285847.2 → NP_001272776.1  membrane progestin receptor alpha

      See identical proteins and their annotated locations for NP_001272776.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
      Source sequence(s)
      AL669982
      Consensus CDS
      CCDS18773.1
      UniProtKB/Swiss-Prot
      Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
      UniProtKB/TrEMBL
      Q3TT73
      Related
      ENSMUSP00000125932.2, ENSMUST00000095074.4
      Conserved Domains (1) summary
      pfam03006
      Location:65 → 289
      HlyIII; Haemolysin-III related

    4. NM_001285849.2 → NP_001272778.1  membrane progestin receptor alpha

      See identical proteins and their annotated locations for NP_001272778.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
      Source sequence(s)
      AL669982
      Consensus CDS
      CCDS18773.1
      UniProtKB/Swiss-Prot
      Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
      UniProtKB/TrEMBL
      Q3TT73
      Conserved Domains (1) summary
      pfam03006
      Location:65 → 289
      HlyIII; Haemolysin-III related

    5. NM_027995.4 → NP_082271.1  membrane progestin receptor alpha

      See identical proteins and their annotated locations for NP_082271.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All variants (1 through 5) encode the same protein.
      Source sequence(s)
      AL669982
      Consensus CDS
      CCDS18773.1
      UniProtKB/Swiss-Prot
      Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
      UniProtKB/TrEMBL
      Q3TT73
      Related
      ENSMUSP00000080240.4, ENSMUST00000081525.4
      Conserved Domains (1) summary
      pfam03006
      Location:65 → 289
      HlyIII; Haemolysin-III related

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      134224315..134237548
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036164451.1 → XP_036020344.1  membrane progestin receptor alpha isoform X1

      UniProtKB/Swiss-Prot
      Q3TDA0, Q80ZE4, Q8BNZ7, Q9D790
      UniProtKB/TrEMBL
      Q3TT73
      Conserved Domains (1) summary
      pfam03006
      Location:65 → 289
      HlyIII; Haemolysin-III related
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80ZE4.2 GenPept UniProtKB/Swiss-Prot:Q80ZE4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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