Pan2 PAN2 poly(A) specific ribonuclease subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pan2provided by MGI
Official Full Name: PAN2 poly(A) specific ribonuclease subunitprovided by MGI
Primary source: MGI:MGI:1918984
See related: Ensembl:ENSMUSG00000005682 AllianceGenome:MGI:1918984
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Usp52; mKIAA0710; 1200014O24Rik
Summary: Predicted to enable poly(A)-specific ribonuclease activity. Predicted to be involved in nuclear-transcribed mRNA poly(A) tail shortening. Predicted to act upstream of or within nuclear-transcribed mRNA catabolic process, exonucleolytic. Located in P-body. Is expressed in 1-cell stage embryo; 2-cell stage embryo; 4-cell stage embryo; primary oocyte; and secondary oocyte. Orthologous to human PAN2 (poly(A) specific ribonuclease subunit PAN2). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in thymus adult (RPKM 19.4), limb E14.5 (RPKM 15.5) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 D3; 10 76.51 cM

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (128135106..128157227)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (128303333..128321358)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1)
Endonuclease-mediated (1)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI047843 (e-PCR)
- UniSTS:165732

NoName (e-PCR)
- UniSTS:236482

AW742773 (e-PCR)
- UniSTS:208625

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 3'-5'-RNA exonuclease activity	ISO Inferred from Sequence Orthology more info
enables exonuclease activity	IEA Inferred from Electronic Annotation more info
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables nuclease activity	IEA Inferred from Electronic Annotation more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
contributes_to poly(A)-specific ribonuclease activity	IBA Inferred from Biological aspect of Ancestor more info
enables poly(A)-specific ribonuclease activity	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within nuclear-transcribed mRNA catabolic process	ISO Inferred from Sequence Orthology more info
involved_in nuclear-transcribed mRNA poly(A) tail shortening	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within nuclear-transcribed mRNA poly(A) tail shortening	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
is_active_in P-body	IBA Inferred from Biological aspect of Ancestor more info
located_in P-body	IDA Inferred from Direct Assay more info	PubMed
part_of PAN complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PAN complex	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: PAN2-PAN3 deadenylation complex catalytic subunit Pan2

Names: AN2 polyA specific ribonuclease subunit homolog; PAB-dependent poly(A)-specific ribonuclease subunit 2; PAB-dependent poly(A)-specific ribonuclease subunit PAN2; PAB1P-dependent poly(A)-nuclease; PAN deadenylation complex catalytic subunit 2; PAN2 polyA specific ribonuclease subunit homolog; inactive ubiquitin carboxyl-terminal hydrolase 52; poly(A)-nuclease deadenylation complex subunit 2; ubiquitin specific peptidase 52; ubiquitin specific protease 52

NP_001239255.1

EC 3.1.13.4

NP_001239256.1

EC 3.1.13.4

NP_001345751.1

EC 3.1.13.4

NP_598753.1

EC 3.1.13.4

XP_006513048.1

EC 3.1.13.4

XP_006513049.1

EC 3.1.13.4

XP_006513050.1

EC 3.1.13.4

XP_006513051.1

EC 3.1.13.4

XP_006513052.1

EC 3.1.13.4

XP_006513053.1

EC 3.1.13.4

XP_036011343.1

EC 3.1.13.4

XP_036011344.1

EC 3.1.13.4

XP_036011345.1

EC 3.1.13.4

XP_036011346.1

EC 3.1.13.4

XP_036011347.1

EC 3.1.13.4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001252326.1 → NP_001239255.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 2

See identical proteins and their annotated locations for NP_001239255.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses a different splice site in the coding region, compared to variant 1. The resulting protein (isoform 2) is shorter when it is compared to isoform 1.

Source sequence(s)

AC135859, AK004773, BC079841, CF170307

Consensus CDS

CCDS88107.1

UniProtKB/Swiss-Prot

Q8BGF7

Related

ENSMUSP00000151216.2, ENSMUST00000218315.2

Conserved Domains (4) summary

cd06143
Location:965 → 1138

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

cd02672
Location:501 → 911

Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam13423
Location:516 → 888

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl02567
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001252327.1 → NP_001239256.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 3

Status: VALIDATED

Description

Transcript Variant: This variant (3) uses two different splice sites in the coding region, compared to variant 1. The resulting protein (isoform 3) is shorter when it is compared to isoform 1.

Source sequence(s)

AC135859, AK004773, AK157800, BG086688

Consensus CDS

CCDS88108.1

UniProtKB/Swiss-Prot

Q8BGF7

Related

ENSMUSP00000151874.2, ENSMUST00000219721.2

Conserved Domains (4) summary

cd06143
Location:947 → 1120

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

cd02672
Location:483 → 893

Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam13423
Location:498 → 870

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl02567
Location:75 → 339

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001358822.1 → NP_001345751.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 4

Status: VALIDATED

Source sequence(s)

AC135859, AK004773, AK047887, CN527165, CX566326

Related

ENSMUST00000218496.2

Conserved Domains (3) summary

cd06143
Location:836 → 1009

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

cd02672
Location:362 → 782

Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

cl25539
Location:21 → 218

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_133992.3 → NP_598753.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform 1

See identical proteins and their annotated locations for NP_598753.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longest transcript and it encodes the longest protein (isoform 1).

Source sequence(s)

AC135859, AK004773, AK047887

Consensus CDS

CCDS24271.1

UniProtKB/Swiss-Prot

Q3TZK5, Q68FH6, Q6ZQ63, Q8BGF7

Related

ENSMUSP00000005825.7, ENSMUST00000005825.8

Conserved Domains (4) summary

cd06143
Location:974 → 1147

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

cd02672
Location:501 → 920

Peptidase_C19P; A subfamily of Peptidase C19. Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyze bonds involving the carboxyl ...

pfam13423
Location:516 → 897

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl02567
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000076.7 Reference GRCm39 C57BL/6J

Range

128135106..128157227

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036155450.1 → XP_036011343.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X1

Conserved Domains (3) summary

cd06143
Location:979 → 1152

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:516 → 902

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006512985.4 → XP_006513048.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X1

Conserved Domains (3) summary

cd06143
Location:979 → 1152

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:516 → 902

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006512989.3 → XP_006513052.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X6

Conserved Domains (3) summary

pfam13423
Location:516 → 902

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl10012
Location:979 → 1092

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006512988.4 → XP_006513051.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X4

Conserved Domains (3) summary

cd06143
Location:970 → 1143

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:516 → 893

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155453.1 → XP_036011346.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X8

Conserved Domains (3) summary

pfam13423
Location:516 → 893

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl10012
Location:970 → 1083

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006512987.4 → XP_006513050.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X3

Conserved Domains (3) summary

cd06143
Location:975 → 1148

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:516 → 898

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155452.1 → XP_036011345.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X7

Conserved Domains (3) summary

pfam13423
Location:516 → 898

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl10012
Location:975 → 1088

DnaQ_like_exo; DnaQ-like (or DEDD) 3'-5' exonuclease domain superfamily

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155451.1 → XP_036011344.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X5

Conserved Domains (3) summary

cd06143
Location:966 → 1139

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:516 → 889

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006512986.4 → XP_006513049.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X2

Conserved Domains (3) summary

cd06143
Location:978 → 1151

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:516 → 901

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:75 → 357

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_006512990.4 → XP_006513053.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X9

Conserved Domains (3) summary

cd06143
Location:840 → 1013

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:377 → 763

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:21 → 218

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
XM_036155454.1 → XP_036011347.1 PAN2-PAN3 deadenylation complex catalytic subunit Pan2 isoform X10

Conserved Domains (3) summary

cd06143
Location:835 → 1008

PAN2_exo; DEDDh 3'-5' exonuclease domain of the eukaryotic exoribonuclease PAN2

pfam13423
Location:377 → 758

UCH_1; Ubiquitin carboxyl-terminal hydrolase

cl29593
Location:21 → 218

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...