Hnrnpll heterogeneous nuclear ribonucleoprotein L-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Hnrnpllprovided by MGI
Official Full Name: heterogeneous nuclear ribonucleoprotein L-likeprovided by MGI
Primary source: MGI:MGI:1919942
See related: Ensembl:ENSMUSG00000024095 AllianceGenome:MGI:1919942
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Hnrpll; 2510028H02Rik; 2810036L13Rik
Summary: Predicted to enable mRNA binding activity. Predicted to be involved in positive regulation of RNA splicing. Predicted to be active in nucleus. Is expressed in brain and sensory organ. Orthologous to human HNRNPLL (heterogeneous nuclear ribonucleoprotein L like). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 34.1), CNS E14 (RPKM 22.4) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 17 E3; 17 50.3 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	17	NC_000083.7 (80336916..80369697, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	17	NC_000083.6 (80029487..80062268, complement)

Chromosome 17 - NC_000083.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells.
Title: Loss of hnRNPLL-dependent splicing of Ptprc has no impact on B-cell development, activation and terminal differentiation into antibody-secreting cells.
Behavioural phenotyping of thunder mice with a hypomorphic mutation of heterogeneous nuclear ribonuclear protein L-like (hnRNPLL) and reduced T cell function.
Title: Behavioural phenotyping of thunder mice with a hypomorphic mutation of heterogeneous nuclear ribonuclear protein L-like (hnRNPLL) and reduced T cell function.
HNRNPLL is a novel metastasis suppressor of colorectal cancer, and modulates alternative splicing of CD44 during epithelial-mesenchymal transition.
Title: HNRNPLL, a newly identified colorectal cancer metastasis suppressor, modulates alternative splicing of CD44 during epithelial-mesenchymal transition.
Data suggest that hnRNPLL specifically associates with cytoplasmic PABPC1 in both T-lymphocytes and plasma cells; PABPC1 promotes binding of hnRNPLL to immunoglobulin H (IgH, heavy chain) mRNA and regulates switching from mIgH (membrane isoform) to sIgH (secreted isoform) in plasma cells. (hnRNPLL = heterogeneous nuclear ribonucleoprotein L-like protein; PABPC1 = cytoplasmic poly[A]-binding protein 1)
Title: Cytoplasmic poly(A)-binding protein 1 (PABPC1) interacts with the RNA-binding protein hnRNPLL and thereby regulates immunoglobulin secretion in plasma cells.
We identify similar patterns of hnRNPLL-induced differential intron retention flanking alternative exons in 14 other genes, representing novel elements of the hnRNPLL-induced splicing program in T cells.
Title: The RNA-binding protein hnRNPLL induces a T cell alternative splicing program delineated by differential intron retention in polyadenylated RNA.
Data indicate that the RNA-binding protein hnRNPLL has a critical role in tuning transcriptomes of terminally differentiating B lymphocytes.
Title: RNA-binding protein hnRNPLL regulates mRNA splicing and stability during B-cell to plasma-cell differentiation.
The splicing factor hnRNPLL and the transcription elongation factor ELL2 modulate the ratio of secred versus membrane-encoding Ighg2b transcripts at the expense of the secreted isoform.
Title: Heterogeneous nuclear ribonucleoprotein L-like (hnRNPLL) and elongation factor, RNA polymerase II, 2 (ELL2) are regulators of mRNA processing in plasma cells.
results highlight both overlapping and divergent roles for hnRNPLL between conventional T cells and NKT cells
Title: Differential requirement for the CD45 splicing regulator hnRNPLL for accumulation of NKT and conventional T cells.
In T cells with no CD45 protein, hnRNPLL mutation diminishes peripheral T cell accumulation and demonstrates that hnRNPLL regulates T cell longevity independently from its effects on CD45 splicing.
Title: Consequences of increased CD45RA and RC isoforms for TCR signaling and peripheral T cell deficiency resulting from heterogeneous nuclear ribonucleoprotein L-like mutation.
A single substitution in a memory-induced RNA-binding protein, hnRNPLL, destabilized an RNA-recognition domain that bound with micromolar affinity to RNA containing the Ptprc exon-silencing sequence.
Title: Memory T cell RNA rearrangement programmed by heterogeneous nuclear ribonucleoprotein hnRNPLL.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Chemically induced (ENU) (1) 1 citation
Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI852082 (e-PCR)
- UniSTS:164628

D10Mit157.2 (e-PCR), detects polymorphism
- UniSTS:126061

NoName (e-PCR)
- UniSTS:237710

NoName (e-PCR)
- UniSTS:237711

RH136073 (e-PCR)
- UniSTS:210068

Hnrpll (e-PCR), detects polymorphism
- UniSTS:479128

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info
enables mRNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables mRNA binding	ISO Inferred from Sequence Orthology more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in mRNA processing	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of RNA splicing	ISO Inferred from Sequence Orthology more info
involved_in regulation of RNA splicing	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of ribonucleoprotein complex	IEA Inferred from Electronic Annotation more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: heterogeneous nuclear ribonucleoprotein L-like

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144802.4 → NP_659051.3 heterogeneous nuclear ribonucleoprotein L-like

See identical proteins and their annotated locations for NP_659051.3

Status: VALIDATED

Source sequence(s)

AK034420, AK146879, AV106949, CJ052186

Consensus CDS

CCDS70845.1

UniProtKB/Swiss-Prot

Q3UIK6, Q6IR44, Q8BIP6, Q91W02, Q921F4, Q99J40

UniProtKB/TrEMBL

Q9CSH0

Related

ENSMUSP00000139372.2, ENSMUST00000184635.8

Conserved Domains (5) summary

cd12700
Location:385 → 455

RRM3_hnRPLL; RNA recognition motif 3 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)

cd12705
Location:501 → 585

RRM4_hnRPLL; RNA recognition motif 4 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)

cd12781
Location:122 → 205

RRM1_hnRPLL; RNA recognition motif 1 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)

cd12786
Location:214 → 309

RRM2_hnRPLL; RNA recognition motif 2 in vertebrate heterogeneous nuclear ribonucleoprotein L-like (hnRNP-LL)

TIGR01649
Location:123 → 590

hnRNP-L_PTB; hnRNP-L/PTB/hephaestus splicing factor family