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    Mthfsl 5, 10-methenyltetrahydrofolate synthetase-like [ Mus musculus (house mouse) ]

    Gene ID: 100039707, updated on 30-Apr-2024

    Summary

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    Official Symbol
    Mthfslprovided by MGI
    Official Full Name
    5, 10-methenyltetrahydrofolate synthetase-likeprovided by MGI
    Primary source
    MGI:MGI:3780550
    See related
    Ensembl:ENSMUSG00000079427 AllianceGenome:MGI:3780550
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm2382
    Summary
    Predicted to enable 5-formyltetrahydrofolate cyclo-ligase activity. Predicted to be involved in folic acid-containing compound biosynthetic process and tetrahydrofolate interconversion. Predicted to be active in mitochondrion. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Orthologous to human ST20-MTHFS (ST20-MTHFS readthrough). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E18 (RPKM 6.6), kidney adult (RPKM 6.4) and 28 other tissues See more
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    Genomic context

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    See Mthfsl in Genome Data Viewer
    Location:
    9 E3.1; 9 47.24 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 9 NC_000075.7 (88567696..88602381, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 9 NC_000075.6 (88685630..88720320, complement)

    Chromosome 9 - NC_000075.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 26567 Neighboring gene predicted gene 29415 Neighboring gene predicted gene, 53509 Neighboring gene STARR-seq mESC enhancer starr_24858 Neighboring gene STARR-seq mESC enhancer starr_24859 Neighboring gene STARR-positive B cell enhancer ABC_E3851 Neighboring gene STARR-positive B cell enhancer ABC_E10574 Neighboring gene STARR-positive B cell enhancer mm9_chr9:88626551-88626852 Neighboring gene predicted gene 10634 Neighboring gene STARR-seq mESC enhancer starr_24860 Neighboring gene B cell leukemia/lymphoma 2 related protein A1d Neighboring gene predicted gene, 53511

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Decrease in the T-box1 gene expression in embryonic brain and adult hippocampus of down syndrome mouse models. Shimizu R, et al. Biochem Biophys Res Commun, 2021 Jan 8. PMID 33348080
    2. Inactivation of the microRNA-183/96/182 cluster results in syndromic retinal degeneration. Lumayag S, et al. Proc Natl Acad Sci U S A, 2013 Feb 5. PMID 23341629, Free PMC Article
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC37660

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 5-formyltetrahydrofolate cyclo-ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 5-formyltetrahydrofolate cyclo-ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables folic acid binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in folic acid catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in folic acid-containing compound biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in glutamate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrofolate interconversion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tetrahydrofolate interconversion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in tetrahydrofolate metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitochondrial matrix ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    5, 10-methenyltetrahydrofolate synthetase-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128601.1 → NP_001122073.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710
      Consensus CDS
      CCDS52881.1
      UniProtKB/TrEMBL
      L7N466, Q3TYX5
      Related
      ENSMUSP00000108734.4, ENSMUST00000113110.5
      Conserved Domains (1) summary
      pfam01812
      Location:10 → 198
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

    2. NM_001359992.1 → NP_001346921.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710
      Consensus CDS
      CCDS90638.1
      UniProtKB/TrEMBL
      Q8R1G5
      Conserved Domains (1) summary
      pfam01812
      Location:1 → 141
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

    3. NM_001411334.1 → NP_001398263.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    4. NM_001411335.1 → NP_001398264.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      CT030710

    5. NM_001411336.1 → NP_001398265.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    6. NM_001411337.1 → NP_001398266.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710
      UniProtKB/TrEMBL
      Q8R1G5
      Related
      ENSMUSP00000150907.2, ENSMUST00000186863.7

    7. NM_001411338.1 → NP_001398267.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710
      UniProtKB/TrEMBL
      Q8R1G5

    8. NM_001411339.1 → NP_001398268.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    9. NM_001411340.1 → NP_001398269.1  5, 10-methenyltetrahydrofolate synthetase-like isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    RNA

    1. NR_177216.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    2. NR_177217.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    3. NR_177218.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    4. NR_177219.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710
      Related
      ENSMUST00000186721.2

    5. NR_177220.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    6. NR_177221.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    7. NR_177222.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    8. NR_177223.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC163666, CT030710

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000075.7 Reference GRCm39 C57BL/6J

      Range
      88567696..88602381 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036154490.1 → XP_036010383.1  5, 10-methenyltetrahydrofolate synthetase-like isoform X1

      Conserved Domains (1) summary
      cl00360
      Location:10 → 126
      5-FTHF_cyc-lig; 5-formyltetrahydrofolate cyclo-ligase family

    RNA

    1. XR_870748.4 RNA Sequence

    2. XR_870750.4 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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