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    Stambp STAM binding protein [ Mus musculus (house mouse) ]

    Gene ID: 70527, updated on 9-May-2024

    Summary

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    Official Symbol
    Stambpprovided by MGI
    Official Full Name
    STAM binding proteinprovided by MGI
    Primary source
    MGI:MGI:1917777
    See related
    Ensembl:ENSMUSG00000006906 AllianceGenome:MGI:1917777
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Amsh; mKIAA4198; 5330424L14Rik; 5730422L11Rik
    Summary
    Predicted to enable Lys63-specific deubiquitinase activity; protein domain specific binding activity; and thiol-dependent deubiquitinase. Acts upstream of or within negative regulation of neuron apoptotic process and protein deubiquitination. Located in cleavage furrow. Is expressed in several structures, including brain; cardiovascular system; genitourinary system; gut; and respiratory system. Orthologous to human STAMBP (STAM binding protein). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in testis adult (RPKM 11.5), CNS E18 (RPKM 8.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Stambp in Genome Data Viewer
    Location:
    6 C3; 6 35.94 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (83520188..83552781, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (83543206..83575826, complement)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_16466 Neighboring gene deoxyguanosine kinase Neighboring gene STARR-positive B cell enhancer ABC_E1066 Neighboring gene actin, gamma 2, smooth muscle, enteric Neighboring gene DENN/MADD domain containing 4C pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E3660 Neighboring gene predicted gene, 21284 Neighboring gene 60S ribosomal protein L5 pseudogene Neighboring gene predicted gene, 57760

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. AMSH is required to degrade ubiquitinated proteins in the central nervous system. Suzuki S, et al. Biochem Biophys Res Commun, 2011 May 20. PMID 21531206
    2. Loss of neurons in the hippocampus and cerebral cortex of AMSH-deficient mice. Ishii N, et al. Mol Cell Biol, 2001 Dec. PMID 11713295, Free PMC Article
    3. Dynamic regulation of ubiquitylation and deubiquitylation at the central spindle during cytokinesis. Mukai A, et al. J Cell Sci, 2008 Apr 15. PMID 18388320
    4. A high-affinity Arg-X-X-Lys SH3 binding motif confers specificity for the interaction between Gads and SLP-76 in T cell signaling. Berry DM, et al. Curr Biol, 2002 Aug 6. PMID 12176364
    5. The complexity of antisense transcription revealed by the study of developing male germ cells. Chan WY, et al. Genomics, 2006 Jun. PMID 16458478

    See all (24) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • KIAA4198

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables K63-linked deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables K63-linked deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables deubiquitinase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal-dependent deubiquitinase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metallopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables peptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of hippocampal neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within mitotic cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of Ras protein signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within negative regulation of hippocampal neuron apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K63-linked deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within protein deubiquitination IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within protein deubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    acts_upstream_of_or_within proteolysis IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cleavage furrow IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cleavage furrow IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cleavage furrow ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endosome IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    STAM-binding protein
    Names
    associated molecule with the SH3 domain of STAM
    NP_001349007.1
    NP_001349008.1
    NP_001349009.1
    NP_077201.1
    XP_006506646.1
    XP_006506647.1
    XP_030111450.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001362078.1 → NP_001349007.1  STAM-binding protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. All four variants encode the same protein.
      Source sequence(s)
      AB010123, AK136961, CJ073582
      Consensus CDS
      CCDS20280.1
      UniProtKB/Swiss-Prot
      Q3UTI9, Q9CQ26
      UniProtKB/TrEMBL
      Q3TGB1
      Related
      ENSMUSP00000146294.2, ENSMUST00000206592.2
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain

    2. NM_001362079.1 → NP_001349008.1  STAM-binding protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' and 3' UTRs compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AB010123, AK019907, CJ073582
      Consensus CDS
      CCDS20280.1
      UniProtKB/Swiss-Prot
      Q3UTI9, Q9CQ26
      UniProtKB/TrEMBL
      Q3TGB1
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain

    3. NM_001362080.1 → NP_001349009.1  STAM-binding protein

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AC090649
      Consensus CDS
      CCDS20280.1
      UniProtKB/Swiss-Prot
      Q3UTI9, Q9CQ26
      UniProtKB/TrEMBL
      Q3TGB1
      Related
      ENSMUSP00000145871.2, ENSMUST00000206400.2
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain

    4. NM_024239.2 → NP_077201.1  STAM-binding protein

      See identical proteins and their annotated locations for NP_077201.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AB010123, AK139391, CJ074803
      Consensus CDS
      CCDS20280.1
      UniProtKB/Swiss-Prot
      Q3UTI9, Q9CQ26
      UniProtKB/TrEMBL
      Q3TGB1
      Related
      ENSMUSP00000070876.8, ENSMUST00000068054.9
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      83520188..83552781 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030255590.2 → XP_030111450.1  STAM-binding protein isoform X1

      UniProtKB/Swiss-Prot
      Q3UTI9, Q9CQ26
      UniProtKB/TrEMBL
      Q3TGB1
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain

    2. XM_006506584.4 → XP_006506647.1  STAM-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006506647.1

      UniProtKB/Swiss-Prot
      Q3UTI9, Q9CQ26
      UniProtKB/TrEMBL
      Q3TGB1
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain

    3. XM_006506583.4 → XP_006506646.1  STAM-binding protein isoform X1

      See identical proteins and their annotated locations for XP_006506646.1

      UniProtKB/Swiss-Prot
      Q3UTI9, Q9CQ26
      UniProtKB/TrEMBL
      Q3TGB1
      Conserved Domains (2) summary
      cd08066
      Location:254 → 424
      MPN_AMSH_like; Mov34/MPN/PAD-1 family
      pfam08969
      Location:8 → 114
      USP8_dimer; USP8 dimerization domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9CQ26.1 GenPept UniProtKB/Swiss-Prot:Q9CQ26

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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