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    Zfp868 zinc finger protein 868 [ Mus musculus (house mouse) ]

    Gene ID: 234362, updated on 21-May-2024

    Summary

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    Official Symbol
    Zfp868provided by MGI
    Official Full Name
    zinc finger protein 868provided by MGI
    Primary source
    MGI:MGI:2142546
    See related
    Ensembl:ENSMUSG00000060427 AllianceGenome:MGI:2142546
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    mszf62; C530032E20
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in several structures, including blastocyst; early embryo; extraembryonic component; genitourinary system; and limb mesenchyme. Orthologous to human ZNF670 (zinc finger protein 670) and ZNF844 (zinc finger protein 844). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 4.4), CNS E14 (RPKM 4.1) and 28 other tissues See more
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    Genomic context

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    See Zfp868 in Genome Data Viewer
    Location:
    8 B3.3; 8 33.88 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (70063305..70078200, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (69610654..69625557, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_21738 Neighboring gene ribosomal protein S7, pseudogene 1 Neighboring gene STARR-seq mESC enhancer starr_21739 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72085257-72085558 Neighboring gene cadherin 11 pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr8:72095951-72096251 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72098669-72098969 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72103212-72103513 Neighboring gene STARR-positive B cell enhancer mm9_chr8:72105793-72106094 Neighboring gene STARR-positive B cell enhancer ABC_E9116 Neighboring gene STARR-positive B cell enhancer ABC_E453 Neighboring gene STARR-seq mESC enhancer starr_21742 Neighboring gene zinc finger protein 964 Neighboring gene STARR-positive B cell enhancer ABC_E9117 Neighboring gene STARR-positive B cell enhancer ABC_E242 Neighboring gene zinc finger protein 869

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Venus trap in the mouse embryo reveals distinct molecular dynamics underlying specification of first embryonic lineages. Dietrich JE, et al. EMBO Rep, 2015 Aug. PMID 26142281, Free PMC Article
    2. Rapid and efficient cloning of cDNAs encoding Krüppel-like zinc finger proteins by degenerate PCR. Agata Y, et al. Gene, 1998 Jun 15. PMID 9630514
    3. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559

    See all (18) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Gene trapped (1)  1 citation

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    Kruppel-like zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001045553.2 → NP_001039018.1  Kruppel-like zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_001039018.1

      Status: VALIDATED

      Source sequence(s)
      AC157564
      Consensus CDS
      CCDS22347.1
      UniProtKB/TrEMBL
      Q3UTQ6
      Conserved Domains (3) summary
      COG5048
      Location:147 → 398
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:324 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 51
      KRAB; KRAB box

    2. NM_001426652.1 → NP_001413581.1  Kruppel-like zinc finger protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157564
      UniProtKB/TrEMBL
      Q3UTQ6

    3. NM_001426653.1 → NP_001413582.1  Kruppel-like zinc finger protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157564
      UniProtKB/TrEMBL
      Q3UTQ6
      Related
      ENSMUSP00000074510.7, ENSMUST00000074982.7

    4. NM_001426654.1 → NP_001413583.1  Kruppel-like zinc finger protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC157564
      UniProtKB/TrEMBL
      Q3UTQ6

    5. NM_001426655.1 → NP_001413584.1  Kruppel-like zinc finger protein isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC157564

    6. NM_172754.3 → NP_766342.2  Kruppel-like zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_766342.2

      Status: VALIDATED

      Source sequence(s)
      AC157564
      Consensus CDS
      CCDS22347.1
      UniProtKB/TrEMBL
      Q3UTQ6
      Related
      ENSMUSP00000113952.2, ENSMUST00000121886.8
      Conserved Domains (3) summary
      COG5048
      Location:147 → 398
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:324 → 344
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:15 → 51
      KRAB; KRAB box

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      70063305..70078200 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243459.2 → XP_030099319.1  Kruppel-like zinc finger protein isoform X3

      Conserved Domains (2) summary
      COG5048
      Location:79 → 330
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:256 → 276
      ZF_C2H2; C2H2 Zn finger [structural motif]
    Nucleotide Protein Strain
    Heading Accession and Version

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