Lpar4 lysophosphatidic acid receptor 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Lpar4provided by MGI
Official Full Name: lysophosphatidic acid receptor 4provided by MGI
Primary source: MGI:MGI:1925384
See related: Ensembl:ENSMUSG00000049929 AllianceGenome:MGI:1925384
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: LPA4; p2y9; Gpr23; 5730485F04Rik
Summary: Enables lysophosphatidic acid binding activity and lysophosphatidic acid receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within signal transduction. Located in plasma membrane. Is expressed in several structures, including branchial arch; future brain; limb; nose; and skeleton. Orthologous to human LPAR4 (lysophosphatidic acid receptor 4). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in limb E14.5 (RPKM 7.9), CNS E11.5 (RPKM 2.4) and 10 other tissues See more
Orthologs: human all
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Genomic context

Location:: X D; X 47.39 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (105964231..105977505)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (106920625..106933899)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The LPAR4 may regulate the recruitment of specific sets of macrophages or their phenotypic switching in a manner that could influence the development of atherosclerosis.
Title: LPA receptor 4 deficiency attenuates experimental atherosclerosis.
the Galpha12/Galpha13-coupled receptors LPA4 and LPA6 synergistically regulate endothelial Dll4 expression through YAP/TAZ activation
Title: Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4.
activation of LPA4 is a promising approach for vascular regulation.
Title: Lysophosphatidic Acid Receptor 4 Activation Augments Drug Delivery in Tumors by Tightening Endothelial Cell-Cell Contact.
LPA4 plays a major role in the lymphocyte transmigration across high endothelial venules
Title: Lysophosphatidic acid receptors LPA4 and LPA6 differentially promote lymphocyte transmigration across high endothelial venules in lymph nodes.
The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells
Title: The lysophosphatidic acid receptor LPA4 regulates hematopoiesis-supporting activity of bone marrow stromal cells.
These results suggest that LPA(4) regulates establishment of the structure and function of blood and lymphatic vessels during mouse embryogenesis
Title: LPA4 regulates blood and lymphatic vessel formation during mouse embryogenesis.
These results provide genetic and biochemical evidence that LPA(4) is a suppressor of LPA-dependent cell migration and invasion in contrast to the motility-stimulating Edg LPA receptors.
Title: Role of LPA4/p2y9/GPR23 in negative regulation of cell motility.
a direct role for LPA receptor signaling in cell transformation and tumorigenesis in conjunction with c-Myc
Title: In vitro genetic screen identifies a cooperative role for LPA signaling and c-Myc in cell transformation.
Affymetrix expression profiling shows that the C terminus of Runx2 regulates genes involved in G protein-coupled receptor signaling Rgs2, Rgs4, Rgs5, Rgs16, Gpr23, Gpr30, Gpr54, Gpr64, and Gna13.
Title: Runx2 regulates G protein-coupled signaling pathways to control growth of osteoblast progenitors.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)
Targeted (4) 1 citation

General gene information

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Markers

RH131472 (e-PCR)
- UniSTS:214755

NoName (e-PCR)
- UniSTS:238065

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info
enables lipid binding	IEA Inferred from Electronic Annotation more info
enables lysophosphatidic acid binding	IDA Inferred from Direct Assay more info	PubMed
enables lysophosphatidic acid receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables lysophosphatidic acid receptor activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of Rho protein signal transduction	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear body	ISO Inferred from Sequence Orthology more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: lysophosphatidic acid receptor 4

Names: G protein-coupled receptor 23; LPA receptor 4; LPA-4; P2Y purinoceptor 9; purinergic receptor 9

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_175271.4 → NP_780480.2 lysophosphatidic acid receptor 4

See identical proteins and their annotated locations for NP_780480.2

Status: VALIDATED

Source sequence(s)

AL670943, BB619126, BC138893

Consensus CDS

CCDS30345.1

UniProtKB/Swiss-Prot

A2ADM5, Q8BKK1, Q8BLG2, Q8VE54

Related

ENSMUSP00000053986.8, ENSMUST00000060576.8

Conserved Domains (1) summary

cd15155
Location:40 → 322

7tmA_LPAR4; lysophosphatidic acid receptor 4, member of the class A family of seven-transmembrane G protein-coupled receptors