Cyp4a12b cytochrome P450, family 4, subfamily a, polypeptide 12B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cyp4a12bprovided by MGI
Official Full Name: cytochrome P450, family 4, subfamily a, polypeptide 12Bprovided by MGI
Primary source: MGI:MGI:3611747
See related: Ensembl:ENSMUSG00000078597 AllianceGenome:MGI:3611747
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Cyp4a12
Summary: Enables arachidonic acid omega-hydroxylase activity. Involved in omega-hydroxylase P450 pathway. Predicted to be located in apical plasma membrane; endoplasmic reticulum membrane; and extracellular space. Predicted to be active in intracellular membrane-bounded organelle. Is expressed in metanephros; nervous system; nose; and respiratory system. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human CYP4A11 (cytochrome P450 family 4 subfamily A member 11) and CYP4A22 (cytochrome P450 family 4 subfamily A member 22). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in liver E18 (RPKM 10.9), genital fat pad adult (RPKM 3.6) and 3 other tissues See more
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Genomic context

Location:: 4 D1; 4 52.99 cM

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	4	NC_000070.7 (115268821..115296231)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	4	NC_000070.6 (115411624..115439034)

Chromosome 4 - NC_000070.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

"...Cyp4a12...is expressed in mouse lung... may be upregulated by...clofibrate and... cytokine IL-1Beta...IL-1Beta has been...associated with asthma...data raise the question...whether CYP4A expression could be altered in asthmatic conditions" p. 184-5
Title: Expression of cytochrome P450 4A mRNA in mouse lung: effect of clofibrate and interleukin-1beta.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

General gene information

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Markers

Cyp4a12b (e-PCR), detects polymorphism
- UniSTS:545922

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables 16-hydroxypalmitate dehydrogenase activity	ISO Inferred from Sequence Orthology more info
enables alkane 1-monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables alkane 1-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid epoxygenase activity	ISO Inferred from Sequence Orthology more info
enables arachidonic acid monooxygenase activity	IBA Inferred from Biological aspect of Ancestor more info
enables arachidonic acid omega-hydroxylase activity	IDA Inferred from Direct Assay more info	PubMed
enables aromatase activity	IEA Inferred from Electronic Annotation more info
enables fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables heme binding	IEA Inferred from Electronic Annotation more info
enables iron ion binding	IEA Inferred from Electronic Annotation more info
enables leukotriene-B4 20-monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables long-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables medium-chain fatty acid omega-hydroxylase activity	ISO Inferred from Sequence Orthology more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables monooxygenase activity	ISO Inferred from Sequence Orthology more info
enables oxidoreductase activity	IEA Inferred from Electronic Annotation more info
enables oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in arachidonic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in arachidonic acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in fatty acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in icosanoid biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in kidney development	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lauric acid metabolic process	ISO Inferred from Sequence Orthology more info
involved_in linoleic acid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in omega-hydroxylase P450 pathway	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in apical plasma membrane	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular space	ISO Inferred from Sequence Orthology more info
is_active_in intracellular membrane-bounded organelle	IBA Inferred from Biological aspect of Ancestor more info
located_in intracellular membrane-bounded organelle	ISO Inferred from Sequence Orthology more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cytochrome P450 4A12B

Names: cytochrome P450, family 4, subfamily a family; cytochrome P450, family 4, subfamily a, polypeptide 12

NP_758510.2

EC 1.14.14.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_172306.2 → NP_758510.2 cytochrome P450 4A12B precursor

Status: VALIDATED

Source sequence(s)

AK098123, BB665127, BC060945

Consensus CDS

CCDS18490.1

UniProtKB/Swiss-Prot

A2A974

UniProtKB/TrEMBL

B0G0Y1

Related

ENSMUSP00000092487.4, ENSMUST00000094887.4

Conserved Domains (1) summary

cd20678
Location:70 → 503

CYP4B-like; cytochrome P450 family 4, subfamily B and similar cytochrome P450s, including subfamilies A, T, X, and Z

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000070.7 Reference GRCm39 C57BL/6J

Range

115268821..115296231

Download

GenBank, FASTA, Sequence Viewer (Graphics)

Suppressed Reference Sequence(s)

The following Reference Sequences have been suppressed. Explain

NM_007821.2: Suppressed sequence

Description

NM_007821.2: This RefSeq record was removed by NCBI staff. Contact info@ncbi.nlm.nih.gov for further information.