atp6ap1b ATPase H+ transporting accessory protein 1b [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: atp6ap1bprovided by ZNC
Official Full Name: ATPase H+ transporting accessory protein 1bprovided by ZNC
Primary source: ZFIN:ZDB-GENE-020423-2
See related: Ensembl:ENSDARG00000037153 AllianceGenome:ZFIN:ZDB-GENE-020423-2
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: bbl; atp6s1; atp6ap1; fb33b05; wu:fb33b05; zgc:103523; etID36826.23
Summary: Acts upstream of or within several processes, including Kupffer's vesicle development; apical protein localization; and pigment granule organization. Located in plasma membrane. Is expressed in several structures, including Kupffer's vesicle; digestive system; forerunner cell group; integument; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in immunodeficiency 47. Orthologous to human ATP6AP1 (ATPase H+ transporting accessory protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 23

Exon count:: 10

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	23	NC_007134.7 (26079473..26094181)
105	previous assembly	GRCz10 (GCF_000002035.5)	23	NC_007134.6 (26152942..26167637)

Chromosome 23 - NC_007134.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish.
Title: Distinct roles for luminal acidification in apical protein sorting and trafficking in zebrafish.
Depletion of both maternal and zygotic atp6ap1b expression reduced Kupffer's vesicle organ size
Title: The V-ATPase accessory protein Atp6ap1b mediates dorsal forerunner cell proliferation and left-right asymmetry in zebrafish.

Submit: New GeneRIF Correction

General gene information

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Markers

fc84e07.x1 (e-PCR)
- UniSTS:194629

fb33b05.x1 (e-PCR)
- UniSTS:203114

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within Kupffer's vesicle development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within apical protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within determination of left/right asymmetry in lateral mesoderm	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within eye pigment granule organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within melanosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization to plasma membrane	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cellular pH	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of cellular pH	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cilium assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of heart looping	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within regulation of heart looping	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retina development in camera-type eye	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within retinal pigment epithelium development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
part_of proton-transporting V-type ATPase complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: V-type proton ATPase subunit S1b

Names: ATPase, H+ transporting, lysosomal (vacuolar proton pump), subunit 1; ATPase, H+ transporting, lysosomal accessory protein 1; ATPase, H+ transporting, lysosomal accessory protein 1b; bleached blond

NP_775372.2

EC 7.1.2.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173265.2 → NP_775372.2 V-type proton ATPase subunit S1b

Status: VALIDATED

Source sequence(s)

AL845287

UniProtKB/TrEMBL

A0A8N7UZT5, A2AR67

Related

ENSDARP00000110078.2, ENSDART00000129617.4

Conserved Domains (1) summary

pfam05827
Location:310 → 456

ATP-synt_S1; Vacuolar ATP synthase subunit S1 (ATP6S1)