aup1 AUP1 lipid droplet regulating VLDL assembly factor [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: aup1provided by ZNC
Official Full Name: AUP1 lipid droplet regulating VLDL assembly factorprovided by ZNC
Primary source: ZFIN:ZDB-GENE-030131-3375
See related: Ensembl:ENSDARG00000092609 AllianceGenome:ZFIN:ZDB-GENE-030131-3375
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: zgc:73323; zgc:77755; wu:fc37d06
Summary: Predicted to enable ubiquitin binding activity and ubiquitin-protein transferase activator activity. Predicted to be involved in ERAD pathway; lipid droplet formation; and protein localization to lipid droplet. Predicted to be located in lipid droplet. Predicted to be part of Hrd1p ubiquitin ligase ERAD-L complex. Predicted to be active in membrane. Predicted to be integral component of endoplasmic reticulum membrane. Orthologous to human AUP1 (AUP1 lipid droplet regulating VLDL assembly factor). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: human mouse all
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Genomic context

Location:: chromosome: 14

Exon count:: 12

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (5835133..5860187)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (5528296..5553350)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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General gene information

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Markers

fl21a09.x1 (e-PCR)
- UniSTS:202050

fc37d06.x1 (e-PCR)
- UniSTS:188062

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables ubiquitin binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in ERAD pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in ERAD pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in lipid droplet organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein localization to lipid droplet	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in endoplasmic reticulum	IEA Inferred from Electronic Annotation more info
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in lipid droplet	IEA Inferred from Electronic Annotation more info
located_in lipid droplet	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: lipid droplet-regulating VLDL assembly factor AUP1; ancient ubiquitous protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_199690.2 → NP_955984.2 lipid droplet-regulating VLDL assembly factor AUP1

See identical proteins and their annotated locations for NP_955984.2

Status: VALIDATED

Source sequence(s)

BC065447

UniProtKB/Swiss-Prot

Q6P0U2, Q6PBN5

Related

ENSDARP00000054866.4, ENSDART00000054867.6

Conserved Domains (2) summary

cd14420
Location:304 → 348

CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins

cl17185
Location:63 → 263

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis

RefSeqs of Annotated Genomes: Danio rerio Annotation Release 106 details...

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCz11 Primary Assembly

Genomic

NC_007125.7 Reference GRCz11 Primary Assembly

Range

5835133..5860187

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_009307693.3 → XP_009305968.1 ancient ubiquitous protein 1 isoform X2

UniProtKB/TrEMBL

A0A8M3B5L5

Conserved Domains (1) summary

cl17185
Location:63 → 222

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis
XM_005173083.4 → XP_005173140.1 ancient ubiquitous protein 1 isoform X1

UniProtKB/TrEMBL

A0A8M2BKB9

Conserved Domains (2) summary

cd14420
Location:310 → 354

CUE_AUP1; CUE domain found in ancient ubiquitous protein 1 (AUP1) and similar proteins

cl17185
Location:63 → 263

LPLAT; Lysophospholipid acyltransferases (LPLATs) of glycerophospholipid biosynthesis