ssrp1a structure specific recognition protein 1a [Danio rerio (zebrafish)] - Gene

Summary

Official Symbol: ssrp1aprovided by ZNC
Official Full Name: structure specific recognition protein 1aprovided by ZNC
Primary source: ZFIN:ZDB-GENE-031118-9
See related: Ensembl:ENSDARG00000037397 AllianceGenome:ZFIN:ZDB-GENE-031118-9
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Danio rerio
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Actinopterygii; Neopterygii; Teleostei; Ostariophysi; Cypriniformes; Danionidae; Danioninae; Danio
Also known as: ssrp1; wu:fa11b03; wu:fd10f06
Summary: Predicted to enable histone binding activity and nucleosome binding activity. Acts upstream of or within regulation of cell cycle. Predicted to be located in chromosome and nucleus. Predicted to be part of FACT complex. Is expressed in eye; liver; and pectoral fin. Orthologous to human SSRP1 (structure specific recognition protein 1). [provided by Alliance of Genome Resources, Apr 2022]
Orthologs: all
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Genomic context

Location:: chromosome: 14

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
106	current	GRCz11 (GCF_000002035.6)	14	NC_007125.7 (21980446..22015326, complement)
105	previous assembly	GRCz10 (GCF_000002035.5)	14	NC_007125.6 (21683201..21718081, complement)

Chromosome 14 - NC_007125.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
Description: Sequencing the Zebrafish transcriptome from a range of tissues and developmental stages
BioProject: PRJEB1986
Analysis date: Fri Dec 8 19:48:10 2017

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Ssrp1a is essential for proliferation and differentiation during eye and liver organogenesis.
Title: Ssrp1a controls organogenesis by promoting cell cycle progression and RNA synthesis.

Submit: New GeneRIF Correction

General gene information

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Markers

fb72g03.x1 (e-PCR)
- UniSTS:187419

fd10f06.x1 (e-PCR)
- UniSTS:195118

fb72g03.x1 (e-PCR)
- UniSTS:191116

aa494805 (e-PCR)
- UniSTS:186825

Gene Ontology Provided by ZFIN

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables histone binding	IBA Inferred from Biological aspect of Ancestor more info
enables nucleosome binding	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA damage response	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA repair	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within DNA replication	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of chromatin organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
part_of FACT complex	IBA Inferred from Biological aspect of Ancestor more info
located_in chromosome	IEA Inferred from Electronic Annotation more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: FACT complex subunit SSRP1a

Names: structure specific recognition protein 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_212802.2 → NP_997967.2 FACT complex subunit SSRP1a

Status: VALIDATED

Source sequence(s)

AA494805, BX510356, CT594375, CT607671

UniProtKB/TrEMBL

A0A8M1PHY6, F1QEB4

Related

ENSDARP00000114529.1, ENSDART00000137795.3

Conserved Domains (4) summary

COG5165
Location:21 → 512

POB3; Nucleosome-binding factor SPN, POB3 subunit [Transcription / DNA replication, recombination, and repair / Chromatin structure and dynamics]

cd13231
Location:333 → 428

PH2_SSRP1-like; Structure Specific Recognition protein 1 (SSRP1) Pleckstrin homology (PH) domain, repeat 2

pfam00505
Location:546 → 613

HMG_box; HMG (high mobility group) box

pfam03531
Location:75 → 285

SSrecog; Structure-specific recognition protein (SSRP1)