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    Dtwd1 DTW domain containing 1 [ Mus musculus (house mouse) ]

    Gene ID: 69185, updated on 5-Mar-2024

    Summary

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    Official Symbol
    Dtwd1provided by MGI
    Official Full Name
    DTW domain containing 1provided by MGI
    Primary source
    MGI:MGI:1916435
    See related
    Ensembl:ENSMUSG00000023330 AllianceGenome:MGI:1916435
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    1810033A06Rik
    Summary
    Predicted to enable tRNA-uridine aminocarboxypropyltransferase activity. Predicted to be involved in tRNA modification. Predicted to act upstream of or within tRNA processing. Predicted to be active in nucleus. Orthologous to human DTWD1 (DTW domain containing 1). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in liver E14 (RPKM 7.2), liver E14.5 (RPKM 5.8) and 24 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dtwd1 in Genome Data Viewer
    Location:
    2 F1; 2 61.76 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (125993981..126007197)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (126152085..126165277)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 227, member B Neighboring gene fibroblast growth factor 7 Neighboring gene predicted gene, 26496 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:125977713-125977822 Neighboring gene predicted gene, 54149 Neighboring gene STARR-seq mESC enhancer starr_05598 Neighboring gene STARR-seq mESC enhancer starr_05599 Neighboring gene STARR-seq mESC enhancer starr_05600 Neighboring gene STARR-positive B cell enhancer ABC_E2643 Neighboring gene STARR-seq mESC enhancer starr_05601 Neighboring gene STARR-seq mESC enhancer starr_05602 Neighboring gene STARR-seq mESC enhancer starr_05603 Neighboring gene STARR-positive B cell enhancer mm9_chr2:126188755-126189056 Neighboring gene ATPase, class I, type 8B, member 4 Neighboring gene Brca1 associated protein 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Normalization and subtraction: two approaches to facilitate gene discovery. Bonaldo MF, et al. Genome Res, 1996 Sep. PMID 8889548
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables tRNA-uridine aminocarboxypropyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables tRNA-uridine aminocarboxypropyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transferase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in tRNA modification IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in tRNA modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within tRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    tRNA-uridine aminocarboxypropyltransferase 1
    Names
    DTW domain-containing protein 1
    NP_001342512.1
    NP_081257.1
    XP_006500193.1
    XP_006500194.1
    XP_006500195.1
    XP_036018427.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001355583.1 → NP_001342512.1  tRNA-uridine aminocarboxypropyltransferase 1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AL929175
      Consensus CDS
      CCDS16682.1
      UniProtKB/Swiss-Prot
      Q9D8U7
      Conserved Domains (1) summary
      pfam03942
      Location:66 → 285
      DTW; DTW domain

    2. NM_026981.2 → NP_081257.1  tRNA-uridine aminocarboxypropyltransferase 1

      See identical proteins and their annotated locations for NP_081257.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 both encode the same protein.
      Source sequence(s)
      AK007678, BM899290, BY240339
      Consensus CDS
      CCDS16682.1
      UniProtKB/Swiss-Prot
      Q9D8U7
      Related
      ENSMUSP00000127662.2, ENSMUST00000170908.8
      Conserved Domains (1) summary
      pfam03942
      Location:66 → 285
      DTW; DTW domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      125993981..126007197
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500132.5 → XP_006500195.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

      Conserved Domains (1) summary
      pfam03942
      Location:88 → 241
      DTW; DTW domain

    2. XM_036162534.1 → XP_036018427.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X2

      Conserved Domains (1) summary
      pfam03942
      Location:88 → 241
      DTW; DTW domain

    3. XM_006500130.3 → XP_006500193.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006500193.1

      UniProtKB/Swiss-Prot
      Q9D8U7
      Conserved Domains (1) summary
      pfam03942
      Location:66 → 285
      DTW; DTW domain

    4. XM_006500131.3 → XP_006500194.1  tRNA-uridine aminocarboxypropyltransferase 1 isoform X1

      See identical proteins and their annotated locations for XP_006500194.1

      UniProtKB/Swiss-Prot
      Q9D8U7
      Conserved Domains (1) summary
      pfam03942
      Location:66 → 285
      DTW; DTW domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D8U7.1 GenPept UniProtKB/Swiss-Prot:Q9D8U7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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