Fam3b FAM3 metabolism regulating signaling molecule B [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam3bprovided by MGI
Official Full Name: FAM3 metabolism regulating signaling molecule Bprovided by MGI
Primary source: MGI:MGI:1270150
See related: Ensembl:ENSMUSG00000022938 AllianceGenome:MGI:1270150
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2-21; ORF9; Pander; D16Jhu19e; 9030624C24Rik
Summary: Involved in insulin secretion. Predicted to be located in nuclear envelope lumen. Predicted to be active in extracellular space. Is expressed in several structures, including branchial arch; heart; stomach; surface ectoderm; and testis. Orthologous to human FAM3B (FAM3 metabolism regulating signaling molecule B). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Biased expression in large intestine adult (RPKM 78.3), colon adult (RPKM 39.8) and 4 other tissues See more
Orthologs: human all
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Genomic context

Location:: 16 C4; 16 57.47 cM

Exon count:: 8

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	16	NC_000082.7 (97272165..97306136, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	16	NC_000082.6 (97470965..97504936, complement)

Chromosome 16 - NC_000082.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

these findings indicate that intestinal L cells are responsive to PANDER, and elevated PANDER levels impair GLP-1 production in vitro and in vivo.
Title: Pancreatic-derived factor impaired glucagon-like Peptide-1 production from GLUTag enterendorine L-cell line and intestines.
PANDER strongly impacts hepatic lipid metabolism across metabolic states and may induce a selective hepatic insulin resistant phenotype via the LXR pathway.
Title: Quantitative proteomic profiling reveals hepatic lipogenesis and liver X receptor activation in the PANDER transgenic model.
in-vitro and in-vivo glucose is a potent stimulator of the PANDER promoter within the liver and this response may be facilitated by ChREBP.
Title: Hepatic nutrient and hormonal regulation of the PANcreatic-DERived factor (PANDER) promoter.
F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression
Title: F3MB(PANDER) decreases mice hepatic triglyceride and is associated with decreased DGAT1 expression.
X-ray crystal structure of the mouse FAM3B protein.
Title: FAM3B PANDER and FAM3C ILEI represent a distinct class of signaling molecules with a non-cytokine-like fold.
these results demonstrated that the JNK-mediated signaling mechanism of palmitic acid -induced beta-cell apoptosis involves up-regulated expression of PANDER and activation of caspase-3.
Title: Effect of PANDER in βTC6-cell lipoapoptosis and the protective role of exendin-4.
Data suggest a new link between the endocrine and immune systems and provide useful information for further investigating the physiological functions of PANDER and its involvement in inflammation-related pancreatic disorders.
Title: Upregulation of pancreatic derived factor (FAM3B) expression in pancreatic β-cells by MCP-1 (CCL2).
Palmitic acid induces the expression of PANDER and the apoptosis of beta-TC3 cells while glucagon-like peptide-1 counteracts the above effects through an activation of Akt signaling.
Title: [Effects of glucagon-like peptide-1 on the free fatty acid-induced expression of pancreatic derived factor in cultured β-TC3 cell line].
PANDER promotes lipogenesis and compromises insulin signaling in the liver by increasing FOXO1 activity.
Title: Pancreatic-derived factor promotes lipogenesis in the mouse liver: role of the Forkhead box 1 signaling pathway.
Findings further indicate PANDER impacts glycemic levels and may represent a potential but complicated therapeutic target.
Title: PANDER KO mice on high-fat diet are glucose intolerant yet resistant to fasting hyperglycemia and hyperinsulinemia.

Submit: New GeneRIF Correction See all GeneRIFs (19)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (4) 1 citation

General gene information

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Markers

ORF9 (e-PCR), detects polymorphism
- UniSTS:259122

ORF9 (e-PCR), detects polymorphism
- UniSTS:259644

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables carbohydrate binding	IEA Inferred from Electronic Annotation more info
enables cytokine activity	NAS Non-traceable Author Statement more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in insulin secretion	IBA Inferred from Biological aspect of Ancestor more info
involved_in insulin secretion	IDA Inferred from Direct Assay more info	PubMed
involved_in insulin secretion	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in extracellular region	NAS Non-traceable Author Statement more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear envelope lumen	ISO Inferred from Sequence Orthology more info	PubMed

General protein information

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Preferred Names: protein FAM3B

Names: cytokine-like protein 2-21; family with sequence similarity 3, member B; pancreatic-derived factor

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.