Fam13a family with sequence similarity 13, member A [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Fam13aprovided by MGI
Official Full Name: family with sequence similarity 13, member Aprovided by MGI
Primary source: MGI:MGI:1889842
See related: Ensembl:ENSMUSG00000037709 AllianceGenome:MGI:1889842
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Precm1; FAM13A1; D430015B01Rik
Summary: Human ortholog(s) of this gene implicated in chronic obstructive pulmonary disease. Orthologous to human FAM13A (family with sequence similarity 13 member A). [provided by Alliance of Genome Resources, Apr 2022]
Expression: Broad expression in mammary gland adult (RPKM 11.1), kidney adult (RPKM 10.9) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 6 B3; 6 27.93 cM

Exon count:: 18

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	6	NC_000072.7 (58910521..59001487, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	6	NC_000072.6 (58933536..59024502, complement)

Chromosome 6 - NC_000072.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors.
Title: Tempo-spatial regulation of the Wnt pathway by FAM13A modulates the stemness of alveolar epithelial progenitors.
Loss of Family with Sequence Similarity 13, Member A Exacerbates Pulmonary Fibrosis Potentially by Promoting Epithelial to Mesenchymal Transition.
Title: Loss of Family with Sequence Similarity 13, Member A Exacerbates Pulmonary Fibrosis Potentially by Promoting Epithelial to Mesenchymal Transition.
GWAS-associated variants within the FAM13A locus alter adipose FAM13A expression, which in turn, regulates adipocyte differentiation and contribute to changes in body fat distribution.
Title: FAM13A affects body fat distribution and adipocyte function.
Fam13a expression was reduced in the lungs of mice with hypoxia-induced pulmonary hypertension. Genetic loss of Fam13a exacerbated pulmonary hypertension in mice exposed to chronic hypoxia in association with deteriorated pulmonary artery remodeling. Study data revealed a protective role of Fam13a in the development of pulmonary hypertension.
Title: Loss of family with sequence similarity 13, member A exacerbates pulmonary hypertension through accelerating endothelial-to-mesenchymal transition.
Fam13a(-/-) mice only exhibited a tendency of higher adiposity and were not protected from DIO and insulin resistance. While Fam13a(-/-) SVCs maintained normal adipogenesis, overexpression of FAM13A in 3T3-L1 preadipocytes downregulated beta-catenin signaling and rendered preadipocytes more susceptible to apoptosis
Title: Obesity-associated family with sequence similarity 13, member A (FAM13A) is dispensable for adipose development and insulin sensitivity.
Genetic loss of Fam13a exacerbated obesity-related metabolic disorders.
Title: Family with sequence similarity 13, member A modulates adipocyte insulin signaling and preserves systemic metabolic homeostasis.
A genetic locus within the FAM13A gene has been consistently associated with chronic obstructive pulmonary disease (COPD) in genome-wide association studies.
Title: A Chronic Obstructive Pulmonary Disease Susceptibility Gene, FAM13A, Regulates Protein Stability of β-Catenin.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Targeted (6) 1 citation

General gene information

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Markers

AI462012 (e-PCR)
- UniSTS:159509

NoName (e-PCR)
- UniSTS:235455

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info

Component	Evidence Code	Pubs
is_active_in cellular_component	ND No biological Data available more info

General protein information

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Preferred Names: protein FAM13A

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.