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    Polr1f RNA polymerase I subunit F [ Mus musculus (house mouse) ]

    Gene ID: 28071, updated on 11-Apr-2024

    Summary

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    Official Symbol
    Polr1fprovided by MGI
    Official Full Name
    RNA polymerase I subunit Fprovided by MGI
    Primary source
    MGI:MGI:106292
    See related
    Ensembl:ENSMUSG00000020561 AllianceGenome:MGI:106292
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Twistnb; D16Wsu83e; 2410173G11; 2810024J17Rik
    Summary
    Predicted to enable DNA-directed 5'-3' RNA polymerase activity. Acts upstream of or within cellular response to leukemia inhibitory factor. Predicted to be located in nucleus. Predicted to be part of RNA polymerase I complex. Is expressed in extraembryonic component. Orthologous to human POLR1F (RNA polymerase I subunit F). [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in ovary adult (RPKM 9.0), adrenal adult (RPKM 6.8) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Polr1f in Genome Data Viewer
    Location:
    12 A3; 12 14.38 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (33479593..33491434)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (33429624..33439380)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene ataxin 7-like 1 Neighboring gene ataxin 7-like 1, opposite strand 2 Neighboring gene STARR-seq mESC enhancer starr_31895 Neighboring gene EF-hand calcium binding domain 10 Neighboring gene STARR-seq mESC enhancer starr_31896 Neighboring gene STARR-positive B cell enhancer ABC_E2381 Neighboring gene predicted gene, 23529 Neighboring gene ribosomal protein SA pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Identification and characterisation of the gene TWIST NEIGHBOR (TWISTNB) located in the microdeletion syndrome 7p21 region. Kosan C, et al. Cytogenet Genome Res, 2002. PMID 12438708
    2. Partial transcriptome of the developing pituitary gland. Douglas KR, et al. Genomics, 2000 Dec 15. PMID 11161784
    3. Genome-wide mapping of unselected transcripts from extraembryonic tissue of 7.5-day mouse embryos reveals enrichment in the t-complex and under-representation on the X chromosome. Ko MS, et al. Hum Mol Genet, 1998 Nov. PMID 9811942
    4. miRNA 34a, 100, and 137 modulate differentiation of mouse embryonic stem cells. Tarantino C, et al. FASEB J, 2010 Sep. PMID 20439489
    5. ATG5 is required for B cell polarization and presentation of particulate antigens. Arbogast F, et al. Autophagy, 2019 Feb. PMID 30196744, Free PMC Article

    See all (21) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA-templated transcription initiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within cellular response to leukemia inhibitory factor IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in transcription elongation by RNA polymerase I IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of DNA-directed RNA polymerase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase I complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    DNA-directed RNA polymerase I subunit RPA43
    Names
    DNA-directed RNA polymerase I subunit F
    twist basic helix-loop-helix transcription factor 1 neighbor
    twist neighbor protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172253.2 → NP_758457.1  DNA-directed RNA polymerase I subunit RPA43

      See identical proteins and their annotated locations for NP_758457.1

      Status: VALIDATED

      Source sequence(s)
      AK010829, AK016638, AK160682
      Consensus CDS
      CCDS25877.1
      UniProtKB/Swiss-Prot
      Q3U6L1, Q78WZ7, Q8CEP7, Q9CS60
      UniProtKB/TrEMBL
      B2RT77
      Related
      ENSMUSP00000020877.8, ENSMUST00000020877.9
      Conserved Domains (1) summary
      cd04328
      Location:43 → 126
      RNAP_I_Rpa43_N; RNAP_I_Rpa43_N: Rpa43, N-terminal ribonucleoprotein (RNP) domain. Rpa43 is a subunit of eukaryotic RNA polymerase (RNAP) I that is homologous to Rpb7 of eukaryotic RNAP II, Rpc25 of eukaryotic RNP III, and RpoE of archaeal RNAP. Rpa43 has two domains, an ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      33479593..33491434
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036157465.1 → XP_036013358.1  DNA-directed RNA polymerase I subunit RPA43 isoform X1

      Conserved Domains (1) summary
      pfam17875
      Location:100 → 125
      RPA43_OB; RPA43 OB domain in RNA Pol I
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q78WZ7.1 GenPept UniProtKB/Swiss-Prot:Q78WZ7

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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